Gene Review:
Col2a1 - collagen, type II, alpha 1
Mus musculus
Synonyms:
Alpha-1 type II collagen, Col2, Col2a, Col2a-1, Collagen alpha-1(II) chain, ...
- The role of collagen II and cartilage fibril-associated molecules in skeletal development. Aszódi, A., Hunziker, E.B., Olsen, B.R., Fässler, R. Osteoarthr. Cartil. (2001)
- Impact of mutations of cartilage matrix genes on matrix structure, gene activity and chondrogenesis. So, C.L., Kaluarachchi, K., Tam, P.P., Cheah, K.S. Osteoarthr. Cartil. (2001)
- A zinc finger transcription factor, alphaA-crystallin binding protein 1, is a negative regulator of the chondrocyte-specific enhancer of the alpha1(II) collagen gene. Tanaka, K., Matsumoto, Y., Nakatani, F., Iwamoto, Y., Yamada, Y. Mol. Cell. Biol. (2000)
- Use of a new rat chondrosarcoma cell line to delineate a 119-base pair chondrocyte-specific enhancer element and to define active promoter segments in the mouse pro-alpha 1(II) collagen gene. Mukhopadhyay, K., Lefebvre, V., Zhou, G., Garofalo, S., Kimura, J.H., de Crombrugghe, B. J. Biol. Chem. (1995)
- A missense mutation in the mouse Col2a1 gene causes spondyloepiphyseal dysplasia congenita, hearing loss, and retinoschisis. Donahue, L.R., Chang, B., Mohan, S., Miyakoshi, N., Wergedal, J.E., Baylink, D.J., Hawes, N.L., Rosen, C.J., Ward-Bailey, P., Zheng, Q.Y., Bronson, R.T., Johnson, K.R., Davisson, M.T. J. Bone Miner. Res. (2003)
- Abnormal response to physical activity in femurs after heterozygous inactivation of one allele of the Col2a1 gene for type II collagen in mice. Nieminen, J., Sahlman, J., Hirvonen, T., Jämsä, T., Tuukkanen, J., Kovanen, V., Kröger, H., Jurvelin, J., Arita, M., Li, S.W., Prockop, D.J., Hyttinen, M.M., Helminen, H.J., Lapveteläinen, T., Puustjärvi, K. Calcif. Tissue Int. (2005)
- SOX9 directly regulates the type-II collagen gene. Bell, D.M., Leung, K.K., Wheatley, S.C., Ng, L.J., Zhou, S., Ling, K.W., Sham, M.H., Koopman, P., Tam, P.P., Cheah, K.S. Nat. Genet. (1997)
- Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone. Li, S.W., Prockop, D.J., Helminen, H., Fässler, R., Lapveteläinen, T., Kiraly, K., Peltarri, A., Arokoski, J., Lui, H., Arita, M. Genes Dev. (1995)
- Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. Zhong, J., Eliceiri, B., Stupack, D., Penta, K., Sakamoto, G., Quertermous, T., Coleman, M., Boudreau, N., Varner, J.A. J. Clin. Invest. (2003)
- Collagen II is essential for the removal of the notochord and the formation of intervertebral discs. Aszódi, A., Chan, D., Hunziker, E., Bateman, J.F., Fässler, R. J. Cell Biol. (1998)
- Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Esteban, C.R., Zemmyo, M., Furumatsu, T., Lotz, M., Belmonte, J.C., Asahara, H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Up regulation of cathepsin K expression in articular chondrocytes in a transgenic mouse model for osteoarthritis. Morko, J.P., Söderström, M., Säämänen, A.M., Salminen, H.J., Vuorio, E.I. Ann. Rheum. Dis. (2004)
- The chondrogenic transcription factor Sox9 is a target of signaling by the parathyroid hormone-related peptide in the growth plate of endochondral bones. Huang, W., Chung, U.I., Kronenberg, H.M., de Crombrugghe , B. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. Seki, K., Fujimori, T., Savagner, P., Hata, A., Aikawa, T., Ogata, N., Nabeshima, Y., Kaechoong, L. J. Biol. Chem. (2003)
- Depletion of cartilage collagen fibrils in mice carrying a dominant negative Col2a1 transgene affects chondrocyte differentiation. Barbieri, O., Astigiano, S., Morini, M., Tavella, S., Schito, A., Corsi, A., Di Martino, D., Bianco, P., Cancedda, R., Garofalo, S. Am. J. Physiol., Cell Physiol. (2003)
- Parallel expression of Sox9 and Col2a1 in cells undergoing chondrogenesis. Zhao, Q., Eberspaecher, H., Lefebvre, V., De Crombrugghe, B. Dev. Dyn. (1997)
- L-Sox5, Sox6 and Sox9 control essential steps of the chondrocyte differentiation pathway. Lefebvre, V., Behringer, R.R., de Crombrugghe, B. Osteoarthr. Cartil. (2001)
- Type II and type IX collagen transcript isoforms are expressed during mouse testis development. McClive, P.J., Sinclair, A.H. Biol. Reprod. (2003)
- Developmental expression analysis of murine autotaxin (ATX). Bächner, D., Ahrens, M., Betat, N., Schröder, D., Gross, G. Mech. Dev. (1999)
- Dexamethasone enhances SOX9 expression in chondrocytes. Sekiya, I., Koopman, P., Tsuji, K., Mertin, S., Harley, V., Yamada, Y., Shinomiya, K., Nifuji, A., Noda, M. J. Endocrinol. (2001)
- Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen. Maddox, B.K., Garofalo, S., Smith, C., Keene, D.R., Horton, W.A. Dev. Dyn. (1997)
- Retarded skeletal development in transgenic mice with a type II collagen mutation. Savontaus, M., Metsranta, M., Vuorio, E. Am. J. Pathol. (1996)
- FGF signaling antagonizes cytokine-mediated repression of Sox9 in SW1353 chondrosarcoma cells. Schaefer, J.F., Millham, M.L., de Crombrugghe, B., Buckbinder, L. Osteoarthr. Cartil. (2003)
- The transcription factor Sox9 is involved in BMP-2 signaling. Zehentner, B.K., Dony, C., Burtscher, H. J. Bone Miner. Res. (1999)
- VEGFA is necessary for chondrocyte survival during bone development. Zelzer, E., Mamluk, R., Ferrara, N., Johnson, R.S., Schipani, E., Olsen, B.R. Development (2004)
- Chondrocyte-specific enhancer elements in the Col11a2 gene resemble the Col2a1 tissue-specific enhancer. Bridgewater, L.C., Lefebvre, V., de Crombrugghe, B. J. Biol. Chem. (1998)
- A 182 bp fragment of the mouse pro alpha 1(II) collagen gene is sufficient to direct chondrocyte expression in transgenic mice. Zhou, G., Garofalo, S., Mukhopadhyay, K., Lefebvre, V., Smith, C.N., Eberspaecher, H., de Crombrugghe, B. J. Cell. Sci. (1995)
- Mint represses transactivation of the type II collagen gene enhancer through interaction with alpha A-crystallin-binding protein 1. Yang, X., Li, J., Qin, H., Yang, H., Li, J., Zhou, P., Liang, Y., Han, H. J. Biol. Chem. (2005)
- Oligonucleotide decoy mimicking alphaA-crystallin-binding protein 1 binding site on mouse Col2a1 enhancer stimulates transcription from the adjacent Col2a1 promoter in chondrogenic ATDC5 cell. Yamagiwa, H., Yamada, Y., Bolander, M.E., Sarkar, G. Mol. Biotechnol. (2004)
- Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in a transgenic mouse model of osteoarthritis. Salminen, H., Vuorio, E., Säämänen, A.M. Arthritis Rheum. (2001)