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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Maternal Deprivation

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Disease relevance of Maternal Deprivation

  • In addition to a slight reduction in birth weight, prenatal stress was associated with elevated corticosterone levels (33.8%) after 1 h of maternal deprivation on postnatal day 1, whereas by postnatal day 8 this pattern was reversed (-46.5%) [1].

Psychiatry related information on Maternal Deprivation


High impact information on Maternal Deprivation

  • These findings suggest that maternal deprivation elicits a specific suppression of growth hormone release which mediates the decrease in ornithine decarboxylase activity [4].
  • After 24 hr of maternal deprivation, significant elevations in ACTH and the naturally occurring glucocorticoid corticosterone (CORT) are observed during the stress-hyporesponsive period [5].
  • Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions [6].
  • For this purpose, the role of mineralocorticoid receptors (MR) and glucocorticoid receptors (GR) in control of HPA activity was examined during the SHRP and in response to 24 h of maternal deprivation [7].
  • Elevations of CSF CRF have also been reported in adult laboratory animals exposed to the stress of brief maternal deprivation or maternal neglect in the neonatal or preweaning period [8].

Chemical compound and disease context of Maternal Deprivation


Biological context of Maternal Deprivation


Anatomical context of Maternal Deprivation


Gene context of Maternal Deprivation


Analytical, diagnostic and therapeutic context of Maternal Deprivation


  1. Prenatal stress and neonatal rat brain development. Van den Hove, D.L., Steinbusch, H.W., Scheepens, A., Van de Berg, W.D., Kooiman, L.A., Boosten, B.J., Prickaerts, J., Blanco, C.E. Neuroscience (2006) [Pubmed]
  2. Maternal absence and stability of individual differences in CSF 5-HIAA concentrations in rhesus monkey infants. Shannon, C., Schwandt, M.L., Champoux, M., Shoaf, S.E., Suomi, S.J., Linnoila, M., Higley, J.D. The American journal of psychiatry. (2005) [Pubmed]
  3. Vulnerability of synaptic plasticity in the complexin II knockout mouse to maternal deprivation stress. Yamauchi, Y., Qin, L.H., Nishihara, M., Sawada, K., Kato, K., Inoue, S. Brain Res. (2005) [Pubmed]
  4. Selective depression of serum growth hormone during maternal deprivation in rat pups. Kuhn, C.M., Butler, S.R., Schanberg, S.M. Science (1978) [Pubmed]
  5. Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone. van Oers, H.J., de Kloet, E.R., Whelan, T., Levine, S. J. Neurosci. (1998) [Pubmed]
  6. Postnatal repeated maternal deprivation produces age-dependent changes of brain-derived neurotrophic factor expression in selected rat brain regions. Roceri, M., Cirulli, F., Pessina, C., Peretto, P., Racagni, G., Riva, M.A. Biol. Psychiatry (2004) [Pubmed]
  7. Glucocorticoid receptor blockade disinhibits pituitary-adrenal activity during the stress hyporesponsive period of the mouse. Schmidt, M.V., Schmidt, M., Levine, S., Oitzl, M.S., van der Mark, M., Müller, M.B., Holsboer, F., de Kloet, E.R. Endocrinology (2005) [Pubmed]
  8. Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects. Carpenter, L.L., Tyrka, A.R., McDougle, C.J., Malison, R.T., Owens, M.J., Nemeroff, C.B., Price, L.H. Neuropsychopharmacology (2004) [Pubmed]
  9. The long-term effects of maternal deprivation depend on the genetic background. Ellenbroek, B.A., Cools, A.R. Neuropsychopharmacology (2000) [Pubmed]
  10. Early life stress changes concentrations of neuropeptide Y and corticotropin-releasing hormone in adult rat brain. Lithium treatment modifies these changes. Husum, H., Mathé, A.A. Neuropsychopharmacology (2002) [Pubmed]
  11. Maternal deprivation stress exacerbates cognitive deficits in immature rats with recurrent seizures. Huang, L.T., Holmes, G.L., Lai, M.C., Hung, P.L., Wang, C.L., Wang, T.J., Yang, C.H., Liou, C.W., Yang, S.N. Epilepsia (2002) [Pubmed]
  12. Effects of prolonged social isolation on responses of neurons in the bed nucleus of the stria terminalis, preoptic area, and hypothalamic paraventricular nucleus to stimulation of the medial amygdala. Sánchez, M.M., Aguado, F., Sánchez-Toscano, F., Saphier, D. Psychoneuroendocrinology (1995) [Pubmed]
  13. Selective loss of ornithine decarboxylase response to adrenergic agonists and glucagon during food deprivation of neonatal rats. Kuhn, C.M., McMillian, M.K., Schanberg, S.M. J. Pharmacol. Exp. Ther. (1983) [Pubmed]
  14. Effect of early life stress on serotonin responses in the hippocampus of young adult rats. van Riel, E., van Gemert, N.G., Meijer, O.C., Joëls, M. Synapse (2004) [Pubmed]
  15. Effects of neonatal pyridostigmine treatment on sexual maturation and adult behaviour in female rats subjected to maternal deprivation. Tönjes, R., Hecht, K., Hinz, G., Döcke, F., Dörner, G. Endokrinologie. (1981) [Pubmed]
  16. Differential and age-dependent effects of maternal deprivation on the hypothalamic-pituitary-adrenal axis of brown norway rats from youth to senescence. Workel, J.O., Oitzl, M.S., Fluttert, M., Lesscher, H., Karssen, A., de Kloet, E.R. J. Neuroendocrinol. (2001) [Pubmed]
  17. Differences in modification of stress mechanisms in rat pups exposed to continuous and intermittent maternal deprivation. Pagava, K.I., Gogberishvili, K. Bull. Exp. Biol. Med. (2004) [Pubmed]
  18. Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats. Husum, H., Termeer, E., Mathé, A.A., Bolwig, T.G., Ellenbroek, B.A. Neuropharmacology (2002) [Pubmed]
  19. Regulation of the developing hypothalamic-pituitary-adrenal axis in corticotropin releasing hormone receptor 1-deficient mice. Schmidt, M.V., Schmidt, M., Oitzl, M.S., Müller, M.B., Ohl, F., Wurst, W., Holsboer, F., Levine, S., De Kloet, E.R. Neuroscience (2003) [Pubmed]
  20. Epigenetic control of neurobehavioural plasticity: the role of neurotrophins. Branchi, I., Francia, N., Alleva, E. Behavioural pharmacology. (2004) [Pubmed]
  21. Corticotropin releasing factor receptor type II (CRF2) messenger ribonucleic acid levels in the hypothalamic ventromedial nucleus of the infant rat are reduced by maternal deprivation. Eghbal-Ahmadi, M., Hatalski, C.G., Avishai-Eliner, S., Baram, T.Z. Endocrinology (1997) [Pubmed]
  22. Altered dendritic spine density in animal models of depression and in response to antidepressant treatment. Norrholm, S.D., Ouimet, C.C. Synapse (2001) [Pubmed]
  23. Developmental pattern of ornithine decarboxylase activity, S-adenosylmethionine decarboxylase, and polyamines of rat adrenal glands. Ekker, M., Sourkes, T.L. Biol. Neonate (1987) [Pubmed]
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