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Cplx1  -  complexin 1

Rattus norvegicus

Synonyms: CPX I, Complexin I, Complexin-1, Synaphin-2
 
 
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Psychiatry related information on Cplx1

 

High impact information on Cplx1

 

Biological context of Cplx1

 

Anatomical context of Cplx1

 

Associations of Cplx1 with chemical compounds

 

Other interactions of Cplx1

  • However, vesicular synaptotagmin and cytosolic complexin, both implicated in the fusion process, exhibited differential ability to interact with the SNARE complexes formed by syntaxins 1-4, suggesting that the plasma membrane syntaxins may mediate vesicle fusion events with different properties [10].
 

Analytical, diagnostic and therapeutic context of Cplx1

  • Brain slices were used for in situ hybridizations with 35S labelled RNA probes of the genes complexin I, complexin II and syntaxin 1 A, the SNARE complex protein interacting with the complexins, and assessed semi-quantitatively for region-specific expression levels [6].

References

  1. Downregulation of complexin I and complexin II in the medial thalamus is blocked by N-acetylcysteine in experimental Wernicke's encephalopathy. Hazell, A.S., Wang, C. J. Neurosci. Res. (2005) [Pubmed]
  2. SNARE complex oligomerization by synaphin/complexin is essential for synaptic vesicle exocytosis. Tokumaru, H., Umayahara, K., Pellegrini, L.L., Ishizuka, T., Saisu, H., Betz, H., Augustine, G.J., Abe, T. Cell (2001) [Pubmed]
  3. Role of secretory carrier membrane protein SCAMP2 in granule exocytosis. Liu, L., Guo, Z., Tieu, Q., Castle, A., Castle, D. Mol. Biol. Cell (2002) [Pubmed]
  4. Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion process. Tadokoro, S., Nakanishi, M., Hirashima, N. J. Cell. Sci. (2005) [Pubmed]
  5. Single-molecule studies of synaptotagmin and complexin binding to the SNARE complex. Bowen, M.E., Weninger, K., Ernst, J., Chu, S., Brunger, A.T. Biophys. J. (2005) [Pubmed]
  6. Antidepressants differentially affect expression of complexin I and II RNA in rat hippocampus. Zink, M., Rapp, S., Gebicke-Haerter, P.J., Henn, F.A., Thome, J. Psychopharmacology (Berl.) (2005) [Pubmed]
  7. Immunohistochemical distribution of the two isoforms of synaphin/complexin involved in neurotransmitter release: localization at the distinct central nervous system regions and synaptic types. Yamada, M., Saisu, H., Ishizuka, T., Takahashi, H., Abe, T. Neuroscience (1999) [Pubmed]
  8. Long-term treatment with haloperidol decreases the mRNA levels of complexin I, but not complexin II, in rat prefrontal cortex, nucleus accumbens and ventral tegmental area. Nakahara, T., Motomura, K., Hashimoto, K., Ueki, H., Gotoh, L., Hondo, H., Tsutsumi, T., Kuroki, T., Hirano, M., Uchimura, H. Neurosci. Lett. (2000) [Pubmed]
  9. Effect of sodium nitrite on the alpha-chlorohydrin-induced lesion of the testis--epididymis complexin the rat. Kalla, N.R., Singh, B. J. Reprod. Fertil. (1979) [Pubmed]
  10. Promiscuous interaction of SNAP-25 with all plasma membrane syntaxins in a neuroendocrine cell. Bajohrs, M., Darios, F., Peak-Chew, S.Y., Davletov, B. Biochem. J. (2005) [Pubmed]
 
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