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Gene Review

Dnm2  -  dynamin 2

Rattus norvegicus

Synonyms: Dyn2, Dynamin-2
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High impact information on Dnm2

  • Here we show that cortactin associates with the Golgi to regulate the actin- and Dyn2-dependent transport of cargo [1].
  • These findings support the idea of an Arf1-activated recruitment of an actin, cortactin and Dyn2 complex that is essential for Golgi function [1].
  • It binds directly to dynamin-2 (Dyn2), a large GTPase that mediates the formation of vesicles from the plasma membrane and the Golgi [1].
  • Furthermore, selective disruption of the cortactin-Dyn2 interaction significantly reduces the levels of Dyn2 at the Golgi and blocks the transit of nascent proteins from the trans-Golgi network, resulting in swollen and distended cisternae [1].
  • By Northern blot analysis and isoform-specific PCR, Dyn2 was found ubiquitously in adult rat tissues as two transcripts of 3.5 kb and 4 kb; the highest levels were found in testis [2].

Biological context of Dnm2


Anatomical context of Dnm2


Associations of Dnm2 with chemical compounds

  • Dynamin-2 molecules with mutant pleckstrin homology domains or deleted proline-rich domains (PRD) exerted dominant negative inhibition on the endocytosis of radiolabeled angiotensin II [3].
  • In cells expressing a dominant-negative mutant of protein phosphatase 2A, dopamine failed to dephosphorylate dynamin-2 and to reduce Na(+),K(+)-ATPase activity [7].

Physical interactions of Dnm2


Other interactions of Dnm2


Analytical, diagnostic and therapeutic context of Dnm2


  1. Actin and Arf1-dependent recruitment of a cortactin-dynamin complex to the Golgi regulates post-Golgi transport. Cao, H., Weller, S., Orth, J.D., Chen, J., Huang, B., Chen, J.L., Stamnes, M., McNiven, M.A. Nat. Cell Biol. (2005) [Pubmed]
  2. Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues. Cook, T.A., Urrutia, R., McNiven, M.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  3. Role of the proline-rich domain of dynamin-2 and its interactions with Src homology 3 domains during endocytosis of the AT1 angiotensin receptor. Szaszák, M., Gáborik, Z., Turu, G., McPherson, P.S., Clark, A.J., Catt, K.J., Hunyady, L. J. Biol. Chem. (2002) [Pubmed]
  4. Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. Shajahan, A.N., Timblin, B.K., Sandoval, R., Tiruppathi, C., Malik, A.B., Minshall, R.D. J. Biol. Chem. (2004) [Pubmed]
  5. Localization of dynamin 2 in rat seminiferous tubules during the spermatogenic cycle. Iguchi, H., Watanabe, M., Kamitani, A., Nagai, A., Hosoya, O., Tsutsui, K., Kumon, H. Acta Med. Okayama (2002) [Pubmed]
  6. Caveolin-1 interacts directly with dynamin-2. Yao, Q., Chen, J., Cao, H., Orth, J.D., McCaffery, J.M., Stan, R.V., McNiven, M.A. J. Mol. Biol. (2005) [Pubmed]
  7. Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis. Efendiev, R., Yudowski, G.A., Zwiller, J., Leibiger, B., Katz, A.I., Berggren, P.O., Pedemonte, C.H., Leibiger, I.B., Bertorello, A.M. J. Biol. Chem. (2002) [Pubmed]
  8. The metabotropic glutamate receptor mGluR5 is endocytosed by a clathrin-independent pathway. Fourgeaud, L., Bessis, A.S., Rossignol, F., Pin, J.P., Olivo-Marin, J.C., Hémar, A. J. Biol. Chem. (2003) [Pubmed]
  9. Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin. Sun, T.X., Van Hoek, A., Huang, Y., Bouley, R., McLaughlin, M., Brown, D. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
  10. Distribution of dynamins in testis and their possible relation to spermatogenesis. Kamitani, A., Yamada, H., Kinuta, M., Watanabe, M., Li, S.A., Matsukawa, T., McNiven, M., Kumon, H., Takei, K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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