The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Itgae  -  integrin alpha E, epithelial-associated

Mus musculus

Synonyms: A530055J10, CD103, Integrin alpha M290, Integrin alpha-E, aM290, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Itgae


Psychiatry related information on Itgae

  • The antinociceptive activity (tail immersion test) and the locomotor activity (photocell actometers) were measured. alpha-E administered icv or ith induced an evident antinociceptive effect which was prevented by the previous naloxone injection [4].

High impact information on Itgae


Biological context of Itgae

  • We cloned the murine integrin gene encoding alpha E, localized it to chromosome 11, and generated integrin alpha E-deficient mice [10].
  • Such susceptible phenotype can be restored when T(reg) from wild-type mice were transferred in CD103(-/-) mice [11].
  • Further study showed that CD103, a cell-adhesion molecule that binds E-cadherin, was highly upregulated in in vivo-generated ACAID T regs and was necessary for their suppression of T-cell activation in vitro [12].
  • Collectively, these data document a pivotal role for TGF-beta-dependent CD103 expression in dictating the gut tropism, and hence the destructive potential, of CD8(+) T cells during GVHD pathogenesis [13].
  • In the present study we have explored the notion that another enhancer found in the far 3' region of the IgH locus (3' alpha E) takes on an important regulatory role in cells that have reached this terminal stage in B cell development [14].

Anatomical context of Itgae


Associations of Itgae with chemical compounds


Physical interactions of Itgae

  • The replacement of the valine found at position beta 29 in E beta k with the glutamic acid found in E beta b results in a selective loss of pigeon cytochrome peptide but not moth cytochrome peptide binding to the resultant mutant E alpha E beta k molecule [19].

Regulatory relationships of Itgae


Other interactions of Itgae


Analytical, diagnostic and therapeutic context of Itgae


  1. Administration of mAb against alpha E beta 7 prevents and ameliorates immunization-induced colitis in IL-2-/- mice. Lúdvíksson, B.R., Strober, W., Nishikomori, R., Hasan, S.K., Ehrhardt, R.O. J. Immunol. (1999) [Pubmed]
  2. Integrin alpha E beta 7 expression on BAL CD4+, CD8+, and gamma delta T-cells in bleomycin-induced lung fibrosis in mouse. Braun, R.K., Sterner-Kock, A., Kilshaw, P.J., Ferrick, D.A., Giri, S.N. Eur. Respir. J. (1996) [Pubmed]
  3. Leucocyte recruitment during enteric nematode infection. McDermott, J.R., Grencis, R.K., Else, K.J. Immunology (2001) [Pubmed]
  4. Spinal effects of alpha-endorphin in mice. Herman, Z.S., Stachura, Z. Polish journal of pharmacology and pharmacy. (1986) [Pubmed]
  5. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Cepek, K.L., Shaw, S.K., Parker, C.M., Russell, G.J., Morrow, J.S., Rimm, D.L., Brenner, M.B. Nature (1994) [Pubmed]
  6. Cell type-specific enhancer element associated with a mouse MHC gene, E beta. Gillies, S.D., Folsom, V., Tonegawa, S. Nature (1984) [Pubmed]
  7. Functional expression of a transfected murine class II MHC gene. Germain, R.N., Norcross, M.A., Margulies, D.H. Nature (1983) [Pubmed]
  8. Failure of T cell receptor V beta negative selection in an athymic environment. Hodes, R.J., Sharrow, S.O., Solomon, A. Science (1989) [Pubmed]
  9. Murine M290 integrin expression modulated by mast cell activation. Smith, T.J., Ducharme, L.A., Shaw, S.K., Parker, C.M., Brenner, M.B., Kilshaw, P.J., Weis, J.H. Immunity (1994) [Pubmed]
  10. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. Schön, M.P., Arya, A., Murphy, E.A., Adams, C.M., Strauch, U.G., Agace, W.W., Marsal, J., Donohue, J.P., Her, H., Beier, D.R., Olson, S., Lefrancois, L., Brenner, M.B., Grusby, M.J., Parker, C.M. J. Immunol. (1999) [Pubmed]
  11. A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. Suffia, I., Reckling, S.K., Salay, G., Belkaid, Y. J. Immunol. (2005) [Pubmed]
  12. CD8+ T regulatory cells use a novel genetic program that includes CD103 to suppress Th1 immunity in eye-derived tolerance. Keino, H., Masli, S., Sasaki, S., Streilein, J.W., Stein-Streilein, J. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  13. TGF-{beta}-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease. El-Asady, R., Yuan, R., Liu, K., Wang, D., Gress, R.E., Lucas, P.J., Drachenberg, C.B., Hadley, G.A. J. Exp. Med. (2005) [Pubmed]
  14. Immunoglobulin gene transcription ceases upon deletion of a distant enhancer. Lieberson, R., Ong, J., Shi, X., Eckhardt, L.A. EMBO J. (1995) [Pubmed]
  15. CD103 expression is required for destruction of pancreatic islet allografts by CD8(+) T cells. Feng, Y., Wang, D., Yuan, R., Parker, C.M., Farber, D.L., Hadley, G.A. J. Exp. Med. (2002) [Pubmed]
  16. The alpha 1 beta 1 and alpha E beta 7 integrins define a subset of dendritic cells in peripheral lymph nodes with unique adhesive and antigen uptake properties. Pribila, J.T., Itano, A.A., Mueller, K.L., Shimizu, Y. J. Immunol. (2004) [Pubmed]
  17. The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells. Chae, W.J., Henegariu, O., Lee, S.K., Bothwell, A.L. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  18. The importance of dominant negative effects of amino acid side chain substitution in peptide-MHC molecule interactions and T cell recognition. Boehncke, W.H., Takeshita, T., Pendleton, C.D., Houghten, R.A., Sadegh-Nasseri, S., Racioppi, L., Berzofsky, J.A., Germain, R.N. J. Immunol. (1993) [Pubmed]
  19. The molecular basis of class II MHC allelic control of T cell responses. Racioppi, L., Ronchese, F., Schwartz, R.H., Germain, R.N. J. Immunol. (1991) [Pubmed]
  20. CCL25 enhances CD103-mediated lymphocyte adhesion to E-cadherin. Ericsson, A., Arya, A., Agace, W. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  21. Peptide-major histocompatibility complex class II complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signaling. Racioppi, L., Ronchese, F., Matis, L.A., Germain, R.N. J. Exp. Med. (1993) [Pubmed]
  22. Regulation of CD103 expression by CD8+ T cells responding to renal allografts. Wang, D., Yuan, R., Feng, Y., El-Asady, R., Farber, D.L., Gress, R.E., Lucas, P.J., Hadley, G.A. J. Immunol. (2004) [Pubmed]
  23. A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins. Sung, S.S., Fu, S.M., Rose, C.E., Gaskin, F., Ju, S.T., Beaty, S.R. J. Immunol. (2006) [Pubmed]
  24. In vivo migration of radiolabelled lymphocytes in rheumatoid synovial tissue engrafted in SCID mice: implication of beta 2 and beta 7-integrin. Jorgensen, C., Couret, I., Hellier, I., Bologna, C., Canovas, F., Brochier, J., Reme, T., Sany, J. J. Rheumatol. (1996) [Pubmed]
  25. Co-expression of CD8 alpha in CD4+ T cell receptor alpha beta + T cells migrating into the murine small intestine epithelial layer. Reimann, J., Rudolphi, A. Eur. J. Immunol. (1995) [Pubmed]
  26. NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation. Singh, M., Birshtein, B.K. Mol. Cell. Biol. (1993) [Pubmed]
  27. MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis. Krajina, T., Leithäuser, F., Reimann, J. Eur. J. Immunol. (2004) [Pubmed]
  28. Analysis of T-T lymphocytes and T-accessory cell interactions using cloned T cells: MHC I restricted cloned T cells activate MHC II restricted T helper cells. Brückner, T., Di Pauli, R. Cell. Immunol. (1986) [Pubmed]
  29. Sequence analysis of rat integrin alpha E1 and alpha E2 subunits: tissue expression reveals phenotypic similarities between intraepithelial lymphocytes and dendritic cells in lymph. Brenan, M., Rees, D.J. Eur. J. Immunol. (1997) [Pubmed]
  30. Polarized integrin mediates human keratinocyte adhesion to basal lamina. De Luca, M., Tamura, R.N., Kajiji, S., Bondanza, S., Rossino, P., Cancedda, R., Marchisio, P.C., Quaranta, V. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  31. T-cell repertoire in a strain of transgenic C57BL/6 mice with the HLA-DRA gene on the X-chromosome. Fukui, Y., Esaki, Y., Kimura, A., Hirokawa, K., Nishimura, Y., Sasazuki, T. Immunogenetics (1993) [Pubmed]
WikiGenes - Universities