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Gene Review

Eomes  -  eomesodermin homolog (Xenopus laevis)

Mus musculus

Synonyms: C77258, Eomesodermin homolog, T-box brain protein 2, T-brain-2, TBR-2, ...
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High impact information on Eomes

  • However, Eomes mutant blastocysts implant, and Cdx2 and Oct4 expression are correctly restricted to the ICM TE [1].
  • A block in early TE differentiation occurs in Eomes mutant blastocysts [1].
  • Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells [2].
  • In uterus, Eomes transcripts greatly outnumbered those of T-bet, whether donors were nonpregnant or pregnant, and increased to gd10 [2].
  • The expression of Tbr1 (Neuron 15 (1995) 63) and Tbr2 (Mech Dev 84 (1999) 133) have virtually identical onset, at around E10.5, and expression domains in the mouse telencephalon [3].

Biological context of Eomes


Anatomical context of Eomes

  • For example, the proliferation of trophoblast stem cells is dependent on FGF signalling and downstream transcription factors Cdx2, Eomes and Err2 [7].
  • Thus, Eomes dominance to T-bet discriminates regulation of the uNK cell subset from that observed for peripheral NK cells [2].
  • Loss-of-function analysis suggests Eomes may also be necessary for full effector differentiation of CD8+ T cells [8].
  • 5. In contrast, Tbr2 mRNA expression was detected in the hippocampus only from E18.5 onwards [9].
  • On embryonic day 14.5 (E14.5), Tbr2 mRNA expression was observed in the mesencephalon and rhombencephalon in contrast to Tbr1 which was expressed mostly in the telencephalon [9].

Regulatory relationships of Eomes

  • This transcription factor sequence is modified in preplate neurons, in which Tbr2 is transiently coexpressed with Tbr1, and in the direct differentiation pathway from radial glia --> postmitotic projection neuron, in which Tbr2 is expressed briefly or not at all [6].

Other interactions of Eomes

  • We now show that Eomesodermin (Eomes), a paralogue of T-bet, is induced in effector CD8+ T cells in vitro and in vivo [8].
  • The rhombic lip-derived cells express transcription factors Pax6, Tbr2, and Tbr1 sequentially as they enter the NTZ [10].
  • To investigate possible structural and functional relationships of Tbr2 and other T-box containing genes, we analyzed genomic organization of the murine Tbr2 gene [5].
  • Accordingly, Tbr2 expression in progenitor compartments (the subventricular zone and ventricular zone) rises and falls with cortical plate neurogenesis [6].

Analytical, diagnostic and therapeutic context of Eomes


  1. Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst. Strumpf, D., Mao, C.A., Yamanaka, Y., Ralston, A., Chawengsaksophak, K., Beck, F., Rossant, J. Development (2005) [Pubmed]
  2. Differential transcription of Eomes and T-bet during maturation of mouse uterine natural killer cells. Tayade, C., Fang, Y., Black, G.P., V A, P., Erlebacher, A., Croy, B.A. J. Leukoc. Biol. (2005) [Pubmed]
  3. Developmental expression of the T-box transcription factor T-bet/Tbx21 during mouse embryogenesis. Faedo, A., Ficara, F., Ghiani, M., Aiuti, A., Rubenstein, J.L., Bulfone, A. Mech. Dev. (2002) [Pubmed]
  4. Expression pattern of the Tbr2 (Eomesodermin) gene during mouse and chick brain development. Bulfone, A., Martinez, S., Marigo, V., Campanella, M., Basile, A., Quaderi, N., Gattuso, C., Rubenstein, J.L., Ballabio, A. Mech. Dev. (1999) [Pubmed]
  5. Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1. Ueno, M., Kimura, N., Nakashima, K., Saito-Ohara, F., Inazawa, J., Taga, T. Gene (2000) [Pubmed]
  6. Pax6, Tbr2, and Tbr1 are expressed sequentially by radial glia, intermediate progenitor cells, and postmitotic neurons in developing neocortex. Englund, C., Fink, A., Lau, C., Pham, D., Daza, R.A., Bulfone, A., Kowalczyk, T., Hevner, R.F. J. Neurosci. (2005) [Pubmed]
  7. Genes, development and evolution of the placenta. Cross, J.C., Baczyk, D., Dobric, N., Hemberger, M., Hughes, M., Simmons, D.G., Yamamoto, H., Kingdom, J.C. Placenta (2003) [Pubmed]
  8. Control of effector CD8+ T cell function by the transcription factor Eomesodermin. Pearce, E.L., Mullen, A.C., Martins, G.A., Krawczyk, C.M., Hutchins, A.S., Zediak, V.P., Banica, M., DiCioccio, C.B., Gross, D.A., Mao, C.A., Shen, H., Cereb, N., Yang, S.Y., Lindsten, T., Rossant, J., Hunter, C.A., Reiner, S.L. Science (2003) [Pubmed]
  9. A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. Kimura, N., Nakashima, K., Ueno, M., Kiyama, H., Taga, T. Brain Res. Dev. Brain Res. (1999) [Pubmed]
  10. Development of the deep cerebellar nuclei: transcription factors and cell migration from the rhombic lip. Fink, A.J., Englund, C., Daza, R.A., Pham, D., Lau, C., Nivison, M., Kowalczyk, T., Hevner, R.F. J. Neurosci. (2006) [Pubmed]
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