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Gene Review

tfap2a  -  transcription factor AP-2 alpha

Danio rerio

Synonyms: SO:0000704, cb93, fb83f04, fc31a07, wu:fb83f04, ...
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Disease relevance of tfap2a


High impact information on tfap2a

  • The expression of the noradrenergic marker genes th and dbh is strongly reduced, as well as the transcription factors gata2 and tfap2a (Ap-2alpha) [2].
  • Zebrafish embryos deficient for both tfap2a and tfap2b show defects in epidermal cell survival and lack NCC-derived cartilages [3].
  • Furthermore, surviving neural crest cells in tfap2a/mob(m610) mutant embryos proliferate normally and later differentiate to individual derivatives [4].
  • Using a positional candidate cloning approach we identified an A to G transition within the 3' splice site of the sixth intron of the tfap2a gene that abolishes the last exon encoding the crucial protein dimerization and DNA-binding domains [4].
  • TUNEL assay and Acridine Orange staining revealed that in the absence of tfap2a a subset of neural crest cells are unable to undergo terminal differentiation and die by apoptosis [4].

Biological context of tfap2a


Anatomical context of tfap2a


  1. Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype. Holzschuh, J., Barrallo-Gimeno, A., Ettl, A.K., Durr, K., Knapik, E.W., Driever, W. Development (2003) [Pubmed]
  2. The bHLH transcription factor hand2 is essential for noradrenergic differentiation of sympathetic neurons. Lucas, M.E., M??ller, F., R??diger, R., Henion, P.D., Rohrer, H. Development (2006) [Pubmed]
  3. AP2-dependent signals from the ectoderm regulate craniofacial development in the zebrafish embryo. Knight, R.D., Javidan, Y., Zhang, T., Nelson, S., Schilling, T.F. Development (2005) [Pubmed]
  4. Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Barrallo-Gimeno, A., Holzschuh, J., Driever, W., Knapik, E.W. Development (2004) [Pubmed]
  5. lockjaw encodes a zebrafish tfap2a required for early neural crest development. Knight, R.D., Nair, S., Nelson, S.S., Afshar, A., Javidan, Y., Geisler, R., Rauch, G.J., Schilling, T.F. Development (2003) [Pubmed]
  6. Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos. Li, W., Cornell, R.A. Dev. Biol. (2007) [Pubmed]
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