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Gene Review

SLEV1  -  systemic lupus erythematosus, vitiligo...

Homo sapiens

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Disease relevance of SLEV1


High impact information on SLEV1

  • Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus [5].
  • Louis encephalitis virus transmission in Indian River County, Florida. We derive an empiric relationship between modeled land surface wetness and levels of SLEV transmission in humans [6].
  • Louis encephalitis virus (SLEV), and dengue virus type 2 (DENV-2) reported earlier, we recently constructed the DENV-1, -3, and -4 VLP expression plasmids [7].
  • The optimal time for performing the fluorescent focus assay (FFA) on Vero cells was 24h for WNV, and 48h for SLEV and the four DENV serotypes [8].
  • A serological survey for yellow fever virus (YFV), dengue 2 virus (DENV-2), and St Louis encephalitis virus (SLEV) was undertaken using a seroneutralization technique in 27 wild forest mammal species (574 individuals) in French Guiana [9].

Biological context of SLEV1

  • The expression plasmid pCB8SJ2, containing the premembrane and envelope structural protein-encoding regions of SLEV, was constructed to express secreted extracellular virus-like particles (VLPs) from CHO cells [3].
  • SLEV-infected K562 and Neuro 2a cells underwent apoptotic cell death, whereas neither the cells inoculated with UV-inactivated virus nor the mock-infected cells developed cytopathic effects [4].
  • These findings suggest that up-regulation of bax mRNA is correlated with cytopathic effects in SLEV-infected K562 cells [4].
  • The complete nucleotide sequence of the envelope gene of this isolate was directly sequenced from the amplified products and compared with other Brazilian and American SLEV strains [10].
  • Louis encephalitis virus (SLEV) from a febrile human case suspected to be dengue, in São Pedro, São Paulo State. A MAC-ELISA done on the patient's acute and convalescent sera was inconclusive and hemagglutination inhibition test detected IgG antibody for flaviviruses [11].

Anatomical context of SLEV1

  • A rise in the expression of the pro-apoptotic bax gene was detected specifically in the SLEV-infected K562 cells [4].
  • To validate this algorithm, we tested 1,418 serum and cerebrospinal fluid (CSF) samples from confirmed WNV and SLEV infections collected during the WNV epidemic of 2002 in the United States. WNV P/N-to-SLEV P/N ratios (W/S ratios) were calculated and used to identify the infecting virus [12].

Analytical, diagnostic and therapeutic context of SLEV1

  • An optimized IgG antibody capture ELISA (GAC-ELISA) with both WNV and SLEV VLPs was developed to circumvent the frequently observed higher background in the antigen-capture IgG-ELISA (ACG-ELISA) [3].
  • Results of BLAST search indicated that this sequence shares 93% nucleotide similarity with the sequence of SLEV (strain-MSI.7), confirmed by RT-PCR performed with SLEV specific primers [11].


  1. Immunization with heterologous flaviviruses protective against fatal West Nile encephalitis. Tesh, R.B., Travassos da Rosa, A.P., Guzman, H., Araujo, T.P., Xiao, S.Y. Emerging Infect. Dis. (2002) [Pubmed]
  2. Sequence and secondary structure analysis of the 5'-terminal region of flavivirus genome RNA. Brinton, M.A., Dispoto, J.H. Virology (1988) [Pubmed]
  3. Noninfectious recombinant antigen for detection of St. Louis encephalitis virus-specific antibodies in serum by enzyme-linked immunosorbent assay. Purdy, D.E., Noga, A.J., Chang, G.J. J. Clin. Microbiol. (2004) [Pubmed]
  4. St. Louis encephalitis virus induced pathology in cultured cells. Parquet, M.C., Kumatori, A., Hasebe, F., Mathenge, E.G., Morita, K. Arch. Virol. (2002) [Pubmed]
  5. Evidence for a susceptibility gene, SLEV1, on chromosome 17p13 in families with vitiligo-related systemic lupus erythematosus. Nath, S.K., Kelly, J.A., Namjou, B., Lam, T., Bruner, G.R., Scofield, R.H., Aston, C.E., Harley, J.B. Am. J. Hum. Genet. (2001) [Pubmed]
  6. Seasonal forecast of St. Louis encephalitis virus transmission, Florida. Shaman, J., Day, J.F., Stieglitz, M., Zebiak, S., Cane, M. Emerging Infect. Dis. (2004) [Pubmed]
  7. Comparative analysis of immunoglobulin M (IgM) capture enzyme-linked immunosorbent assay using virus-like particles or virus-infected mouse brain antigens to detect IgM antibody in sera from patients with evident flaviviral infections. Holmes, D.A., Purdy, D.E., Chao, D.Y., Noga, A.J., Chang, G.J. J. Clin. Microbiol. (2005) [Pubmed]
  8. Quantitation of flaviviruses by fluorescent focus assay. Payne, A.F., Binduga-Gajewska, I., Kauffman, E.B., Kramer, L.D. J. Virol. Methods (2006) [Pubmed]
  9. Wild terrestrial rainforest mammals as potential reservoirs for flaviviruses (yellow fever, dengue 2 and St Louis encephalitis viruses) in French Guiana. de Thoisy, B., Dussart, P., Kazanji, M. Trans. R. Soc. Trop. Med. Hyg. (2004) [Pubmed]
  10. Genetic characterization of St. Louis encephalitis virus isolated from human in São Paulo, Brazil. Santos, C.L., Sallum, M.A., Franco, H.M., Oshiro, F.M., Rocco, I.M. Mem. Inst. Oswaldo Cruz (2006) [Pubmed]
  11. St. Louis encephalitis virus: first isolation from a human in São Paulo State, Brazil. Rocco, I.M., Santos, C.L., Bisordi, I., Petrella, S.M., Pereira, L.E., Souza, R.P., Coimbra, T.L., Bessa, T.A., Oshiro, F.M., Lima, L.B., Cerroni, M.P., Marti, A.T., Barbosa, V.M., Katz, G., Suzuki, A. Rev. Inst. Med. Trop. Sao Paulo (2005) [Pubmed]
  12. Evaluation of a diagnostic algorithm using immunoglobulin M enzyme-linked immunosorbent assay to differentiate human West Nile Virus and St. Louis Encephalitis virus infections during the 2002 West Nile Virus epidemic in the United States. Martin, D.A., Noga, A., Kosoy, O., Johnson, A.J., Petersen, L.R., Lanciotti, R.S. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
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