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Gene Review

CST6  -  cystatin E/M

Homo sapiens

Synonyms: Cystatin-6, Cystatin-E, Cystatin-M
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Disease relevance of CST6


High impact information on CST6


Biological context of CST6


Anatomical context of CST6

  • Additionally, two previously untested antibodies to molecules that have been found to be upregulated in papillary thyroid carcinoma (CST6 and EPS8) were also evaluated [7].
  • Northern blot analysis revealed that the cystatin E gene is expressed in most human tissues, with the highest mRNA amounts found in uterus and liver [3].

Other interactions of CST6

  • The level of cystatin E/M appears to be significantly associated with primary pleural tumours and cystatin F correlates with inflammatory processes of lung disorders [8].


  1. The human cystatin M/E gene (CST6): exclusion candidate gene for harlequin ichthyosis. Zeeuwen, P.L., Dale, B.A., de Jongh, G.J., van Vlijmen-Willems, I.M., Fleckman, P., Kimball, J.R., Stephens, K., Schalkwijk, J. J. Invest. Dermatol. (2003) [Pubmed]
  2. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin. Song, J., Jie, C., Polk, P., Shridhar, R., Clair, T., Zhang, J., Yin, L., Keppler, D. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  3. Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. Ni, J., Abrahamson, M., Zhang, M., Fernandez, M.A., Grubb, A., Su, J., Yu, G.L., Li, Y., Parmelee, D., Xing, L., Coleman, T.A., Gentz, S., Thotakura, R., Nguyen, N., Hesselberg, M., Gentz, R. J. Biol. Chem. (1997) [Pubmed]
  4. Frequent epigenetic inactivation of cystatin M in breast carcinoma. Schagdarsurengin, U., Pfeifer, G.P., Dammann, R. Oncogene (2007) [Pubmed]
  5. Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1. Virtaneva, K., D'Amato, E., Miao, J., Koskiniemi, M., Norio, R., Avanzini, G., Franceschetti, S., Michelucci, R., Tassinari, C.A., Omer, S., Pennacchio, L.A., Myers, R.M., Dieguez-Lucena, J.L., Krahe, R., de la Chapelle, A., Lehesjoki, A.E. Nat. Genet. (1997) [Pubmed]
  6. Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation. Hong, J., Yoshida, K., Rosner, M.R. J. Neurochem. (2002) [Pubmed]
  7. Immunohistochemical markers in diagnosis of papillary thyroid carcinoma: utility of HBME1 combined with CK19 immunostaining. Nasr, M.R., Mukhopadhyay, S., Zhang, S., Katzenstein, A.L. Mod. Pathol. (2006) [Pubmed]
  8. Cystatins C, E/M and F in human pleural fluids of patients with neoplastic and inflammatory lung disorders. Werle, B., Sauckel, K., Nathanson, C.M., Bjarnadottir, M., Spiess, E., Ebert, W., Abrahamson, M. Biol. Chem. (2003) [Pubmed]
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