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Gene Review

Gria4  -  glutamate receptor, ionotropic, AMPA4...

Mus musculus

Synonyms: AMPA-selective glutamate receptor 4, GluA4, GluR-4, GluR-D, GluR4, ...
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Disease relevance of Gria4


High impact information on Gria4


Biological context of Gria4

  • The glutamate-mediated transmission efficiency of synaptic AMPA receptors is influenced by their subunit composition (GluR-A to GluR-D), post-transcriptional and post-translational modifications, the number of synaptic AMPA receptors, and auxiliary proteins [8].

Anatomical context of Gria4


Associations of Gria4 with chemical compounds

  • Using this approach, we obtained a panel of high-affinity antibody fragments that immunoprecipitated both recombinant and native GluRD receptors, but not GluR6, a kainate receptor subunit with a 40% sequence similarity [1].

Other interactions of Gria4

  • Potential candidate genes in this region include Penk2 and Gria4 [13].
  • Two monoclonal antibodies provided some evidence that GluR2 and/or GluR4, as well as NMDAR1 subunit, are present on the rod bipolar cell [14].
  • We detected a slight but statistically significant decrease of the AMPA receptor subunits GluR3 and GluR4 only in end stage disease animals [15].

Analytical, diagnostic and therapeutic context of Gria4

  • Quantitative PCR studies suggested the pronounced expression of PEPA-preferring AMPA receptor subunits (GluR3 and GluR4) and a splice variant (flop) in the mPFC [16].


  1. Use of proteoliposomes to generate phage antibodies against native AMPA receptor. Jespersen, L.K., Kuusinen, A., Orellana, A., Keinänen, K., Engberg, J. Eur. J. Biochem. (2000) [Pubmed]
  2. Light and electron microscopic immunocytochemical localization of AMPA-selective glutamate receptors in the rat spinal cord. Tachibana, M., Wenthold, R.J., Morioka, H., Petralia, R.S. J. Comp. Neurol. (1994) [Pubmed]
  3. Ca(2+)-evoked synaptic transmission and neurotransmitter receptor levels are impaired in the forebrain of trkb (-/-) mice. Carmona, M.A., Martínez, A., Soler, A., Blasi, J., Soriano, E., Aguado, F. Mol. Cell. Neurosci. (2003) [Pubmed]
  4. CD15 immunoreactive amacrine cells in the mouse retina. Jakobs, T.C., Ben, Y., Masland, R.H. J. Comp. Neurol. (2003) [Pubmed]
  5. Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder. Mennini, T., Bigini, P., Ravizza, T., Vezzani, A., Calvaresi, N., Tortarolo, M., Bendotti, C. J. Neurosci. Res. (2002) [Pubmed]
  6. Glutamate receptor-mediated calcium entry in neurons derived from P19 embryonal carcinoma cells. Canzoniero, L.M., Sensi, S.L., Turetsky, D.M., Finley, M.F., Choi, D.W., Huettner, J.E. J. Neurosci. Res. (1996) [Pubmed]
  7. Expression profiling of genes encoding glutamate and GABA receptor subunits in three immortalized GnRH cell lines. Garyfallou, V.T., Lemos, D., Urbanski, H.F. Brain Res. (2006) [Pubmed]
  8. Role of AMPA receptors in synaptic plasticity. Sprengel, R. Cell Tissue Res. (2006) [Pubmed]
  9. Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina. Hack, I., Frech, M., Dick, O., Peichl, L., Brandstätter, J.H. Eur. J. Neurosci. (2001) [Pubmed]
  10. Differential co-localization of neurokinin-3 receptor and NMDA/AMPA receptor subunits in neurons of the substantia nigra of C57/BL mice. Wang, Y.Q., Hu, H.J., Cao, R., Chen, L.W. Brain Res. (2005) [Pubmed]
  11. AMPA receptors in cultured vestibular ganglion neurons: detection and activation. Rabejac, D., Devau, G., Raymond, J. Eur. J. Neurosci. (1997) [Pubmed]
  12. (+/-)-Alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and kainate receptor subunit expression in mouse versus rat spinal cord white matter: similarities in astrocytes but differences in oligodendrocytes. Brand-Schieber, E., Werner, P. Neurosci. Lett. (2003) [Pubmed]
  13. Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross. Patel, N.V., Hitzemann, R.J. Behav. Genet. (1999) [Pubmed]
  14. Are there ionotropic glutamate receptors on the rod bipolar cell of the mouse retina? Hughes, T.E. Vis. Neurosci. (1997) [Pubmed]
  15. The cellular mRNA expression of GABA and glutamate receptors in spinal motor neurons of SOD1 mice. Petri, S., Schmalbach, S., Grosskreutz, J., Krampfl, K., Grothe, C., Dengler, R., Van Den Bosch, L., Robberecht, W., Bufler, J. J. Neurol. Sci. (2005) [Pubmed]
  16. Facilitation of extinction learning for contextual fear memory by PEPA: a potentiator of AMPA receptors. Zushida, K., Sakurai, M., Wada, K., Sekiguchi, M. J. Neurosci. (2007) [Pubmed]
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