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KHDC3L  -  KH domain containing 3-like, subcortical...

Homo sapiens

Synonyms: C6orf221, ECAT1, ES cell-associated transcript 1 protein, HYDM2, KHDC3-like protein
 
 
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Disease relevance of ECAT1

 

High impact information on ECAT1

  • Two-thirds of the region pairs showed significant regressions, although percent differences were quite variable, with measures of glucose utilization ranging from 30 to 120% higher on the PC1024 compared to those from the ECAT II [5].
  • METHODS: Twenty-one patients with coronary artery disease referred for (18)F-FDG PET underwent an imaging protocol of nongated 2D (2D-NG) and gated 2D (2D-G) acquisitions for 15 min each, followed by 3D gated acquisitions for 10 min (3D-10) and 5 min (3D-5), using an ECAT Exact HR+ scanner [6].
  • Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group [7].
  • Levels of ECAT from 0.30 to 0.90 mug/m(3) were significantly associated with infant wheezing [8].
  • Twenty-seven patients (1 female, 26 males, age 62+/-9 years) with lung cancer or indeterminate pulmonary nodules were studied on the same day with a full-ring PET scanner (Siemens ECAT EXACT) and a coincidence gamma camera system (ADAC Vertex MCD) [9].
 

Chemical compound and disease context of ECAT1

  • Global cortical CBF and CVR in 60 patients (66 +/- 12 yrs) with chronic hydrocephalus were investigated before, one week (7 d) and 7 months (7 m) after shunting by 15-O-H2O PET (Siemens ECAT 951/31) at rest and after application of acetazolamide (1 g) [10].
  • METHODS: Fifty-eight patients with clinical suspicion of prostate cancer underwent (11)C-choline PET (25/58, Siemens ECAT Exact HR+) or PET/CT (33/58, Philips Gemini) scanning [11].
 

Biological context of ECAT1

 

Anatomical context of ECAT1

  • We observed a similar hypomethylation of ECAT loci in adult testis and isolated sperm [14].
  • Emission transmission scans of the extra-cranial head, neck and thorax were obtained using an ECAT Exact 47 at least 60 min after injection [16].
 

Associations of ECAT1 with chemical compounds

  • PET-TM was performed on an ECAT EXACT HR+ (CTI/Siemens) equipped with three rod sources of germanium-68 (380 MBq total) and extended septa [17].
  • 18FDG (0.8 mCi/kg; 29.6 MBq) was given i.v. and PET (ECAT 953/31, Siemens) was performed for 90 min [18].
  • Glucose metabolism was studied using an ECAT EXACT 47 positron emission tomography (PET) camera and fluorine-18 fluorodeoxyglucose (18F-FDG); 123I-IMT uptake was measured with the triple-headed single-photon emission tomography (SPET) camera, MULTISPECT 3 [19].
  • The FDG images were acquired with two dedicated PET tomographs [Siemens ECAT 933, CTI (Knoxville, TN) and GE Advance, General Electric Medical Systems (Milwaukee, WI)] one hour after the intravenous administration of 10 mCi of FDG [20].
  • Quantitative imaging of yttrium-86 PET with the ECAT EXACT HR+ in 2D mode [21].
 

Analytical, diagnostic and therapeutic context of ECAT1

  • A study of injected dose for brain mapping on the ECAT HR+: activation maps for a parametric verbal working memory task [22].
  • A dose of about 185 MBq (5 mCi) of these ligands was administered intravenously and a dynamic PET scan with an ECAT 931/08 PET camera was carried out [23].
  • The PET/CT scanner was developed as a combination of a Siemens Somatom AR.SP spiral CT and a partial-ring, rotating ECAT ART PET scanner [24].
  • PET studies in seven healthy human volunteers were performed on a Siemens ECAT EXACT whole-body scanner after injection of 100-280 MBq [L8F]FEF [25].
  • Evaluation of the ECAT EXACT HR+ 3-D PET scanner in H2(15)O brain activation studies: dose fractionation strategies for rCBF and signal enhancing protocols [26].

References

  1. Fibrinolytic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. ECAT Study Group. European Concerted Action on Thrombosis and Disabilities. Juhan-Vague, I., Pyke, S.D., Alessi, M.C., Jespersen, J., Haverkate, F., Thompson, S.G. Circulation (1996) [Pubmed]
  2. Positron emission tomography with [(18)F]fluoro-2-deoxy-D-glucose for diagnosis and staging of bile duct cancer. Kluge, R., Schmidt, F., Caca, K., Barthel, H., Hesse, S., Georgi, P., Seese, A., Huster, D., Berr, F. Hepatology (2001) [Pubmed]
  3. Dose-response relationships of serum lipid measurements with the extent of coronary stenosis. Strong, independent, and comprehensive. ECAT Angina Pectoris Study Group. Bolibar, I., Thompson, S.G., von Eckardstein, A., Sandkamp, M., Assmann, G. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  4. Short-term prognostic value of lipid measurements in patients with angina pectoris. The ECAT Angina Pectoris Study Group: European Concerted Action on Thrombosis and Disabilities. Bolibar, I., von Eckardstein, A., Assmann, G., Thompson, S. Thromb. Haemost. (2000) [Pubmed]
  5. Quantitative comparison of measurements of cerebral glucose metabolic rate made with two positron cameras. Grady, C.L. J. Cereb. Blood Flow Metab. (1991) [Pubmed]
  6. 18F-FDG PET for detecting myocardial viability: validation of 3D data acquisition. Brogsitter, C., Grüning, T., Weise, R., Wielepp, P., Lindner, O., Körfer, R., Burchert, W. J. Nucl. Med. (2005) [Pubmed]
  7. Haemostasis factors in angina pectoris; relation to gender, age and acute-phase reaction. Results of the ECAT Angina Pectoris Study Group. Haverkate, F., Thompson, S.G., Duckert, F. Thromb. Haemost. (1995) [Pubmed]
  8. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Ryan, P.H., Lemasters, G.K., Biswas, P., Levin, L., Hu, S., Lindsey, M., Bernstein, D.I., Lockey, J., Villareal, M., Khurana Hershey, G.K., Grinshpun, S.A. Environ. Health Perspect. (2007) [Pubmed]
  9. Imaging of lung cancer with fluorine-18 fluorodeoxyglucose: comparison of a dual-head gamma camera in coincidence mode with a full-ring positron emission tomography system. Weber, W.A., Neverve, J., Sklarek, J., Ziegler, S.I., Bartenstein, P., King, B., Treumann, T., Enterrottacher, A., Krapf, M., Häussinger, K.E., Lichte, H., Präuer, H.W., Thetter, O., Schwaiger, M. European journal of nuclear medicine. (1999) [Pubmed]
  10. The role of cerebral blood flow and cerebrovascular reserve capacity in the diagnosis of chronic hydrocephalus--a PET-study on 60 patients. Klinge, P., Berding, G., Brinker, T., Schuhmann, M., Weckesser, E., Knapp, W.H., Samii, M. Acta Neurochir. Suppl. (2002) [Pubmed]
  11. Value of (11)C-choline PET and PET/CT in patients with suspected prostate cancer. Scher, B., Seitz, M., Albinger, W., Tiling, R., Scherr, M., Becker, H.C., Souvatzogluou, M., Gildehaus, F.J., Wester, H.J., Dresel, S. Eur. J. Nucl. Med. Mol. Imaging (2007) [Pubmed]
  12. ECAT ART - a continuously rotating PET camera: performance characteristics, initial clinical studies, and installation considerations in a nuclear medicine department. Bailey, D.L., Young, H., Bloomfield, P.M., Meikle, S.R., Glass, D., Myers, M.J., Spinks, T.J., Watson, C.C., Luk, P., Peters, A.M., Jones, T. European journal of nuclear medicine. (1997) [Pubmed]
  13. Measurement of CBF and CMRO2 using the continuous inhalation of C15O2 and 15O. Experimental validation using CO2 reactivity in the anaesthetised dog. Rhodes, C.G., Lenzi, G.L., Frackowiak, R.S., Jones, T., Pozzilli, C. J. Neurol. Sci. (1981) [Pubmed]
  14. Transcriptional repression and DNA hypermethylation of a small set of ES cell marker genes in male germline stem cells. Imamura, M., Miura, K., Iwabuchi, K., Ichisaka, T., Nakagawa, M., Lee, J., Kanatsu-Shinohara, M., Shinohara, T., Yamanaka, S. BMC Dev. Biol. (2006) [Pubmed]
  15. Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. The ECAT Angina Pectoris Study Group. Juhan-Vague, I., Thompson, S.G., Jespersen, J. Arterioscler. Thromb. (1993) [Pubmed]
  16. The impact of FDG PET on the management of occult primary head and neck tumours. Wong, W.L., Saunders, M. Clinical oncology (Royal College of Radiologists (Great Britain)) (2003) [Pubmed]
  17. Dosimetry of transmission measurements in nuclear medicine: a study using anthropomorphic phantoms and thermoluminescent dosimeters. Almeida, P., Bendriem, B., de Dreuille, O., Peltier, A., Perrot, C., Brulon, V. European journal of nuclear medicine. (1998) [Pubmed]
  18. [18F]fluorodeoxyglucose uptake in neonatal acute lung injury measured by positron emission tomography. Kirpalani, H., Abubakar, K., Nahmias, C., deSa, D., Coates, G., Schmidt, B. Pediatr. Res. (1997) [Pubmed]
  19. Non-invasive grading of primary brain tumours: results of a comparative study between SPET with 123I-alpha-methyl tyrosine and PET with 18F-deoxyglucose. Woesler, B., Kuwert, T., Morgenroth, C., Matheja, P., Palkovic, S., Schäfers, M., Vollet, B., Schäfers, K., Lerch, H., Brandau, W., Samnick, S., Wassmann, H., Schober, O. European journal of nuclear medicine. (1997) [Pubmed]
  20. The role of [18F]fluorodeoxyglucose positron emission tomography imaging in the evaluation of hepatocellular carcinoma. Wudel, L.J., Delbeke, D., Morris, D., Rice, M., Washington, M.K., Shyr, Y., Pinson, C.W., Chapman, W.C. The American surgeon. (2003) [Pubmed]
  21. Quantitative imaging of yttrium-86 PET with the ECAT EXACT HR+ in 2D mode. Kull, T., Ruckgaber, J., Weller, R., Reske, S., Glatting, G. Cancer Biother. Radiopharm. (2004) [Pubmed]
  22. A study of injected dose for brain mapping on the ECAT HR+: activation maps for a parametric verbal working memory task. Isoardi, R.A., Townsend, D.W., Carter, C.S., Herbster, A., Dachille, M.A., Meltzer, C.C. Neuroimage (1999) [Pubmed]
  23. PET studies on dopamine D1 receptors in the human brain with carbon-11-SCH 39166 and carbon-11-NNC 756. Laihinen, A.O., Rinne, J.O., Ruottinen, H.M., Någren, K.A., Lehikoinen, P.K., Oikonen, V.J., Ruotsalainen, U.H., Rinne, U.K. J. Nucl. Med. (1994) [Pubmed]
  24. A combined PET/CT scanner for clinical oncology. Beyer, T., Townsend, D.W., Brun, T., Kinahan, P.E., Charron, M., Roddy, R., Jerin, J., Young, J., Byars, L., Nutt, R. J. Nucl. Med. (2000) [Pubmed]
  25. [18F]Fluoroethylflumazenil: a novel tracer for PET imaging of human benzodiazepine receptors. Gründer, G., Siessmeier, T., Lange-Asschenfeldt, C., Vernaleken, I., Buchholz, H.G., Stoeter, P., Drzezga, A., Lüddens, H., Rösch, F., Bartenstein, P. European journal of nuclear medicine. (2001) [Pubmed]
  26. Evaluation of the ECAT EXACT HR+ 3-D PET scanner in H2(15)O brain activation studies: dose fractionation strategies for rCBF and signal enhancing protocols. Moreno-Cantú, J.J., Thompson, C.J., Zatorre, R.J. IEEE transactions on medical imaging. (1998) [Pubmed]
 
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