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Gene Review

Il5ra  -  interleukin 5 receptor, alpha

Mus musculus

Synonyms: CD125, CDw125, IL-5 receptor alpha chain, IL-5 receptor subunit alpha, IL-5R subunit alpha, ...
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Disease relevance of Il5ra


High impact information on Il5ra


Biological context of Il5ra


Anatomical context of Il5ra


Associations of Il5ra with chemical compounds


Physical interactions of Il5ra


Regulatory relationships of Il5ra


Other interactions of Il5ra


Analytical, diagnostic and therapeutic context of Il5ra


  1. Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor alpha chain-deficient mice. Tanaka, H., Kawada, N., Yamada, T., Kawada, K., Takatsu, K., Nagai, H. Clin. Exp. Allergy (2000) [Pubmed]
  2. Impaired vitamin A-mediated mucosal IgA response in IL-5 receptor-knockout mice. Nikawa, T., Ikemoto, M., Kano, M., Tokuoka, K., Hirasaka, K., Uehara, S., Takatsu, K., Rokutan, K., Kishi, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  3. Effect of Interleukin-5 Receptor-alpha Short Hairpin RNA-Expressing Vector on Bone Marrow Eosinophilopoiesis in Asthmatic Mice. Mao, H., Wen, F.Q., Liu, C.T., Liang, Z.A., Wang, Z.L., Yin, K.S. Advances in therapy (2006) [Pubmed]
  4. Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor alpha chain gene. Moon, B.G., Takaki, S., Nishizumi, H., Yamamoto, T., Takatsu, K. Cell. Immunol. (2004) [Pubmed]
  5. Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. Yoshida, T., Ikuta, K., Sugaya, H., Maki, K., Takagi, M., Kanazawa, H., Sunaga, S., Kinashi, T., Yoshimura, K., Miyazaki, J., Takaki, S., Takatsu, K. Immunity (1996) [Pubmed]
  6. Molecular cloning and expression of the human interleukin 5 receptor. Murata, Y., Takaki, S., Migita, M., Kikuchi, Y., Tominaga, A., Takatsu, K. J. Exp. Med. (1992) [Pubmed]
  7. CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5. Kikuchi, Y., Yasue, T., Miyake, K., Kimoto, M., Takatsu, K. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  8. A critical cytoplasmic domain of the interleukin-5 (IL-5) receptor alpha chain and its function in IL-5-mediated growth signal transduction. Takaki, S., Kanazawa, H., Shiiba, M., Takatsu, K. Mol. Cell. Biol. (1994) [Pubmed]
  9. Allergen exposure-induced differences in CD34+ cell phenotype: relationship to eosinophilopoietic responses in different compartments. Sergejeva, S., Johansson, A.K., Malmhäll, C., Lötvall, J. Blood (2004) [Pubmed]
  10. Delineation of IL-5 domains predicted to engage the IL-5 receptor complex. Dickason, R.R., Huston, M.M., Huston, D.P. J. Immunol. (1996) [Pubmed]
  11. Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively. Takagi, M., Hara, T., Ichihara, M., Takatsu, K., Miyajima, A. J. Exp. Med. (1995) [Pubmed]
  12. Interleukin-5 receptor alpha chain expression and splicing during brain development in mice. Lins, C., Borojevic, R. Growth Factors (2001) [Pubmed]
  13. Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5. Kouro, T., Kikuchi, Y., Kanazawa, H., Hirokawa, K., Harada, N., Shiiba, M., Wakao, H., Takaki, S., Takatsu, K. Int. Immunol. (1996) [Pubmed]
  14. IgG1 production by sIgD+ splenic B cells and peritoneal B-1 cells in response to IL-5 and CD38 ligation. Yasue, T., Baba, M., Mori, S., Mizoguchi, C., Uehara, S., Takatsu, K. Int. Immunol. (1999) [Pubmed]
  15. Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells. Itakura, A., Kikuchi, Y., Kouro, T., Ikutani, M., Takaki, S., Askenase, P.W., Takatsu, K. Int. Arch. Allergy Immunol. (2006) [Pubmed]
  16. Comparative analysis of the kinetics of binding and internalization of IL-5 in murine IL-5 receptors of high and low affinity. Mita, S., Takaki, S., Tominaga, A., Takatsu, K. J. Immunol. (1993) [Pubmed]
  17. Expression of oncostatin M in hematopoietic organs. Tamura, S., Morikawa, Y., Miyajima, A., Senba, E. Dev. Dyn. (2002) [Pubmed]
  18. Interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) can induce differentiation of chronic B cell leukemia expressing the alpha subunit of IL-3 and GM-CSF receptor. Shiiba, M., Takaki, S., Takatsu, K. Int. Arch. Allergy Immunol. (1996) [Pubmed]
  19. Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences. Jacob, C.O., Mykytyn, K., Varcony, T., Drabkin, H.A. Mamm. Genome (1993) [Pubmed]
  20. IL-5 receptor expression and Ig secretion from murine B lymphocytes requires coordinated signaling by membrane Ig, IL-4, and IL-5. Weber, J.D., Isakson, P.C., Purkerson, J.M. J. Immunol. (1996) [Pubmed]
  21. Biochemical and functional characterization of soluble form of IL-5 receptor alpha (sIL-5R alpha). Development of ELISA system for detection of sIL-5R alpha. Kikuchi, Y., Migita, M., Takaki, S., Tominaga, A., Takatsu, K. J. Immunol. Methods (1994) [Pubmed]
  22. Interleukin-5 does not influence differential transcription of transmembrane and soluble isoforms of IL-5R alpha in vivo. Byström, J., Dyer, K.D., Ting-De Ravin, S.S., Naumann, N., Stephany, D.A., Foster, P.S., Wynn, T.A., Rosenberg, H.F. Eur. J. Haematol. (2006) [Pubmed]
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