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Gene Review

BRINP1  -  bone morphogenetic protein/retinoic acid...

Homo sapiens

Synonyms: BMP/retinoic acid-inducible neural-specific protein 1, DBC1, DBCCR1, Deleted in bladder cancer protein 1, FAM5A, ...
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Disease relevance of DBC1


High impact information on DBC1

  • Exogenous overexpression of DBC1 in NSCLC cell lines lacking its expression inhibited cell growth [1].
  • Hypermethylation in part of a CpG island around the exon 1 of DBC1 has been reported in urothelial cancers, but the potential association between methylation and expression status was never clarified in that disease [1].
  • Our results provide the first evidence that DBC1 is a likely tumor suppressor for NSCLC; silencing of the gene through homozygous deletion or methylation of its promoter region may be associated with progression of this disease [1].
  • Among our primary NSCLC cases, methylation of the DBC1 promoter occurred more frequently in men, elderly patients and smokers than in women, younger patients and nonsmokers respectively, but it was not correlated with tumor stage or histology [1].
  • All shared INK4a/ARF gene locus deletion and epigenetic silencing of the DBCCR1 tumor suppressor gene [6].

Biological context of DBC1


Anatomical context of DBC1

  • Although DBCCR1 was expressed in multiple normal human tissues including urothelium, mRNA expression was absent in 5 of 10 (50%) bladder cancer cell lines [8].

Associations of DBC1 with chemical compounds


Other interactions of DBC1


Analytical, diagnostic and therapeutic context of DBC1

  • The present study addressed expression of DBCCR1 in gliomas, specifically in astrocytomas, using semi-quantitative RT-PCR on 25 tumours of different malignancy grade and on 5 control brain tissue samples [4].
  • DNA from 34 tumours was examined for loss of heterozygosity (LOH) at three markers surrounding DBCCR1 and for hypermethylation of the DBCCR1 promoter, using methylation-specific PCR and methylation-specific melting-curve analysis [5].


  1. Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. Izumi, H., Inoue, J., Yokoi, S., Hosoda, H., Shibata, T., Sunamori, M., Hirohashi, S., Inazawa, J., Imoto, I. Hum. Mol. Genet. (2005) [Pubmed]
  2. A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. Nishiyama, H., Hornigold, N., Davies, A.M., Knowles, M.A. Genomics (1999) [Pubmed]
  3. Molecular genetic analysis of chromosome 9 candidate tumor-suppressor loci in bladder cancer cell lines. Williams, S.V., Sibley, K.D., Davies, A.M., Nishiyama, H., Hornigold, N., Coulter, J., Kennedy, W.J., Skilleter, A., Habuchi, T., Knowles, M.A. Genes Chromosomes Cancer (2002) [Pubmed]
  4. Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma. Beetz, C., Brodoehl, S., Patt, S., Kalff, R., Deufel, T. Oncol. Rep. (2005) [Pubmed]
  5. Loss of heterozygosity at 9q33 and hypermethylation of the DBCCR1 gene in oral squamous cell carcinoma. Gao, S., Worm, J., Guldberg, P., Eiberg, H., Krogdahl, A., Sørensen, J.A., Liu, C.J., Reibel, J., Dabelsteen, E. Br. J. Cancer (2004) [Pubmed]
  6. Tumorigenic heterogeneity in cancer stem cells evolved from long-term cultures of telomerase-immortalized human mesenchymal stem cells. Burns, J.S., Abdallah, B.M., Guldberg, P., Rygaard, J., Schrøder, H.D., Kassem, M. Cancer Res. (2005) [Pubmed]
  7. Identification of loci associated with putative recurrence genes in transitional cell carcinoma of the urinary bladder. Edwards, J., Duncan, P., Going, J.J., Watters, A.D., Grigor, K.M., Bartlett, J.M. J. Pathol. (2002) [Pubmed]
  8. Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. Habuchi, T., Luscombe, M., Elder, P.A., Knowles, M.A. Genomics (1998) [Pubmed]
  9. DBCCR1 mediates death in cultured bladder tumor cells. Wright, K.O., Messing, E.M., Reeder, J.E. Oncogene (2004) [Pubmed]
  10. Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. Wright, K.O., Messing, E.M., Reeder, J.E. J. Urol. (2002) [Pubmed]
  11. Alterations of the 9p21 and 9q33 chromosomal bands in clinical bladder cancer specimens by fluorescence in situ hybridization. Stadler, W.M., Steinberg, G., Yang, X., Hagos, F., Turner, C., Olopade, O.I. Clin. Cancer Res. (2001) [Pubmed]
  12. Bladder neoplasms--regions at chromosome 9 with putative tumour suppressor genes. Wada, T., Berggren, P., Steineck, G., Adolfsson, J., Wijkström, H., Norming, U., Hansson, J., Hemminki, K., Larsson, P. Scandinavian journal of urology and nephrology. (2003) [Pubmed]
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