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Gene Review

Lgals9  -  lectin, galactose binding, soluble 9

Mus musculus

Synonyms: AA407335, AI194909, AI265545, Gal-9, Galectin-9, ...
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Disease relevance of Lgals9


High impact information on Lgals9


Biological context of Lgals9


Anatomical context of Lgals9

  • Taken together, these findings indicate that galectin-9, a developmentally regulated lectin, plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus [3].
  • For further confirming the cell-cycle regulation by Gal-9, conditionally immortalized mouse podocyte cells were cultured under 5.5 and 25 mM d-glucose supplemented with Gal-9 [1].
  • Indeed, the galectins have non-identical expression profiles, qualitative differences, e.g. seen for galectin-5-positive bone marrow and erythrocytes or for hitherto unknown expression in cells of the theca folliculi and galectin-9-positive skin epidermis and esophageal epithelium [7].
  • Galectin-9, a member of the beta-galactoside-binding animal lectin family, is involved in various cellular biological events, including aggregation and apoptosis, adhesion of cancer cells, and dendritic cell maturation [2].
  • Multivariate analysis revealed that galectin-9 status influenced distant metastasis independent of and much more than lymph node metastasis [2].

Other interactions of Lgals9

  • Collectively, these data indicate that galectin-9 is a new member of the galectin gene family and has a unique intestinal isoform [6].
  • Gal-9 reduced glomerular expression of TGF-beta1 and the number of p27(Kip1)- and p21(Cip1)-positive cells in glomeruli [1].

Analytical, diagnostic and therapeutic context of Lgals9


  1. Galectin-9 inhibits glomerular hypertrophy in db/db diabetic mice via cell-cycle-dependent mechanisms. Baba, M., Wada, J., Eguchi, J., Hashimoto, I., Okada, T., Yasuhara, A., Shikata, K., Kanwar, Y.S., Makino, H. J. Am. Soc. Nephrol. (2005) [Pubmed]
  2. Galectin-9, a novel prognostic factor with antimetastatic potential in breast cancer. Yamauchi, A., Kontani, K., Kihara, M., Nishi, N., Yokomise, H., Hirashima, M. The breast journal. (2006) [Pubmed]
  3. Developmental regulation, expression, and apoptotic potential of galectin-9, a beta-galactoside binding lectin. Wada, J., Ota, K., Kumar, A., Wallner, E.I., Kanwar, Y.S. J. Clin. Invest. (1997) [Pubmed]
  4. Crystal Structure of the Galectin-9 N-terminal Carbohydrate Recognition Domain from Mus musculus Reveals the Basic Mechanism of Carbohydrate Recognition. Nagae, M., Nishi, N., Murata, T., Usui, T., Nakamura, T., Wakatsuki, S., Kato, R. J. Biol. Chem. (2006) [Pubmed]
  5. Isolation and characterization of a novel eosinophil-specific galectin released into the lungs in response to allergen challenge. Dunphy, J.L., Barcham, G.J., Bischof, R.J., Young, A.R., Nash, A., Meeusen, E.N. J. Biol. Chem. (2002) [Pubmed]
  6. Identification and characterization of galectin-9, a novel beta-galactoside-binding mammalian lectin. Wada, J., Kanwar, Y.S. J. Biol. Chem. (1997) [Pubmed]
  7. Unique sequence and expression profiles of rat galectins-5 and -9 as a result of species-specific gene divergence. Lensch, M., Lohr, M., Russwurm, R., Vidal, M., Kaltner, H., André, S., Gabius, H.J. Int. J. Biochem. Cell Biol. (2006) [Pubmed]
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