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Gene Review

Lrp8  -  low density lipoprotein receptor-related...

Mus musculus

Synonyms: 4932703M08Rik, AA921429, AI848122, ApoER2, Apoer2, ...
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Disease relevance of Lrp8

  • Besides brain formation defects, apoER2-deficient mice also exhibit male infertility [1].
  • Because insufficient expression of PHGPx is a major cause of infertility in men, these findings not only highlight an important new function for apoER2 that is unrelated to neuronal migration, but they also suggest a possible role for apoER2 in human infertility [1].

High impact information on Lrp8


Biological context of Lrp8


Anatomical context of Lrp8


Associations of Lrp8 with chemical compounds

  • ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain [9].

Physical interactions of Lrp8

  • Moreover, phosphorylated but not native apoER2' co-precipitated with the Src family member Fgr [10].
  • Binding experiments performed with Chinese hamster ovary cells expressing the human apoER2 showed that the receptor was able to bind VLDL containing either of the apoE isoforms, as well as the apoE-deficient VLDL [11].

Regulatory relationships of Lrp8


Other interactions of Lrp8


Analytical, diagnostic and therapeutic context of Lrp8

  • Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity [18].
  • Confocal microscopy revealed a high degree of co-localization of LDL and a splice variant of the LDL receptor family member apolipoprotein E receptor-2 (apoER2') at the platelet surface, suggesting that apoER2' may contribute to LDL-induced platelet signaling [10].


  1. Essential role of the apolipoprotein E receptor-2 in sperm development. Andersen, O.M., Yeung, C.H., Vorum, H., Wellner, M., Andreassen, T.K., Erdmann, B., Mueller, E.C., Herz, J., Otto, A., Cooper, T.G., Willnow, T.E. J. Biol. Chem. (2003) [Pubmed]
  2. Modulation of synaptic plasticity and memory by Reelin involves differential splicing of the lipoprotein receptor Apoer2. Beffert, U., Weeber, E.J., Durudas, A., Qiu, S., Masiulis, I., Sweatt, J.D., Li, W.P., Adelmann, G., Frotscher, M., Hammer, R.E., Herz, J. Neuron (2005) [Pubmed]
  3. Direct binding of Reelin to VLDL receptor and ApoE receptor 2 induces tyrosine phosphorylation of disabled-1 and modulates tau phosphorylation. Hiesberger, T., Trommsdorff, M., Howell, B.W., Goffinet, A., Mumby, M.C., Cooper, J.A., Herz, J. Neuron (1999) [Pubmed]
  4. Dentate granule cells in reeler mutants and VLDLR and ApoER2 knockout mice. Drakew, A., Deller, T., Heimrich, B., Gebhardt, C., Del Turco, D., Tielsch, A., Förster, E., Herz, J., Frotscher, M. Exp. Neurol. (2002) [Pubmed]
  5. Differential binding of ligands to the apolipoprotein E receptor 2. Andersen, O.M., Benhayon, D., Curran, T., Willnow, T.E. Biochemistry (2003) [Pubmed]
  6. Abnormal positioning of granule cells alters afferent fiber distribution in the mouse fascia dentata: morphologic evidence from reeler, apolipoprotein E receptor 2-, and very low density lipoprotein receptor knockout mice. Gebhardt, C., Del Turco, D., Drakew, A., Tielsch, A., Herz, J., Frotscher, M., Deller, T. J. Comp. Neurol. (2002) [Pubmed]
  7. A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling. Koch, S., Strasser, V., Hauser, C., Fasching, D., Brandes, C., Bajari, T.M., Schneider, W.J., Nimpf, J. EMBO J. (2002) [Pubmed]
  8. Reelin promotes peripheral synapse elimination and maturation. Quattrocchi, C.C., Huang, C., Niu, S., Sheldon, M., Benhayon, D., Cartwright, J., Mosier, D.R., Keller, F., D'Arcangelo, G. Science (2003) [Pubmed]
  9. ApoE Receptor 2 Controls Neuronal Survival in the Adult Brain. Beffert, U., Nematollah Farsian, F., Masiulis, I., Hammer, R.E., Yoon, S.O., Giehl, K.M., Herz, J. Curr. Biol. (2006) [Pubmed]
  10. Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK. Korporaal, S.J., Relou, I.A., van Eck, M., Strasser, V., Bezemer, M., Gorter, G., van Berkel, T.J., Nimpf, J., Akkerman, J.W., Lenting, P.J. J. Biol. Chem. (2004) [Pubmed]
  11. Very-low-density lipoprotein binding to the apolipoprotein E receptor 2 is enhanced by lipoprotein lipase, and does not require apolipoprotein E. Tacken, P.J., Beer, F.D., Vark, L.C., Havekes, L.M., Hofker, M.H., Willems Van Dijk K, n.u.l.l. Biochem. J. (2000) [Pubmed]
  12. Reelin, very-low-density lipoprotein receptor, and apolipoprotein E receptor 2 control somatic NMDA receptor composition during hippocampal maturation in vitro. Sinagra, M., Verrier, D., Frankova, D., Korwek, K.M., Blahos, J., Weeber, E.J., Manzoni, O.J., Chavis, P. J. Neurosci. (2005) [Pubmed]
  13. The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity. Petit-Turcotte, C., Aumont, N., Beffert, U., Dea, D., Herz, J., Poirier, J. Neurobiol. Aging (2005) [Pubmed]
  14. Reelin activates SRC family tyrosine kinases in neurons. Bock, H.H., Herz, J. Curr. Biol. (2003) [Pubmed]
  15. Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1. Keshvara, L., Benhayon, D., Magdaleno, S., Curran, T. J. Biol. Chem. (2001) [Pubmed]
  16. Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Benhayon, D., Magdaleno, S., Curran, T. Brain Res. Mol. Brain Res. (2003) [Pubmed]
  17. Divergent roles of ApoER2 and Vldlr in the migration of cortical neurons. Hack, I., Hellwig, S., Junghans, D., Brunne, B., Bock, H.H., Zhao, S., Frotscher, M. Development (2007) [Pubmed]
  18. Functional dissection of Reelin signaling by site-directed disruption of Disabled-1 adaptor binding to apolipoprotein E receptor 2: distinct roles in development and synaptic plasticity. Beffert, U., Durudas, A., Weeber, E.J., Stolt, P.C., Giehl, K.M., Sweatt, J.D., Hammer, R.E., Herz, J. J. Neurosci. (2006) [Pubmed]
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