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Gene Review

app-1  -  Protein APP-1

Caenorhabditis elegans

 
 
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High impact information on aminopeptidase

 

Biological context of aminopeptidase

  • The sequence of an EST (yk91g4), comprising the open reading frame of W03G9.4, confirmed the predicted genomic structure of the gene and the prediction that W03G9.4 codes for a nonsecreted protein with a molecular mass of 68 kDa [3].
 

Anatomical context of aminopeptidase

  • Aminopeptidase P (AP-P; X-Pro aminopeptidase; EC 3.4.11.9) cleaves the N-terminal X-Pro bond of peptides and occurs in mammals as both cytosolic and plasma membrane forms, encoded by separate genes [3].
 

Associations of aminopeptidase with chemical compounds

 

Other interactions of aminopeptidase

 

Analytical, diagnostic and therapeutic context of aminopeptidase

  • None of the aforementioned AF1 metabolites (2-20 microM) retained biological activity in this bioassay, indicating that the endopeptidase, aminopeptidase and deamidase have the potential to terminate the action of AF1 on locomotory muscle of A. suum [4].

References

  1. The Caenorhabditis elegans orthologue of mammalian puromycin-sensitive aminopeptidase has roles in embryogenesis and reproduction. Brooks, D.R., Hooper, N.M., Isaac, R.E. J. Biol. Chem. (2003) [Pubmed]
  2. Molecular cloning and functional expression of a Caenorhabditis elegans aminopeptidase structurally related to mammalian leukotriene A4 hydrolases. Baset, H.A., Ford-Hutchinson, A.W., O'Neill, G.P. J. Biol. Chem. (1998) [Pubmed]
  3. Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans. Laurent, V., Brooks, D.R., Coates, D., Isaac, R.E. Eur. J. Biochem. (2001) [Pubmed]
  4. Metabolism of AF1 (KNEFIRF-NH2) in the nematode, Ascaris suum, by aminopeptidase, endopeptidase and deamidase enzymes. Sajid, M., Keating, C., Holden-Dye, L., Harrow, I.D., Isaac, R.E. Mol. Biochem. Parasitol. (1996) [Pubmed]
  5. Molecular cloning and demonstration of an aminopeptidase activity in a filarial nematode glycoprotein. Harnett, W., Houston, K.M., Tate, R., Garate, T., Apfel, H., Adam, R., Haslam, S.M., Panico, M., Paxton, T., Dell, A., Morris, H., Brzeski, H. Mol. Biochem. Parasitol. (1999) [Pubmed]
  6. Identification of the secreted neutral proteases from Anisakis simplex. Sakanari, J.A., McKerrow, J.H. J. Parasitol. (1990) [Pubmed]
  7. Aminopeptidases in Caenorhabditis elegans and Panagrellus redivivus: detection using peptide and non-peptide substrates. Masler, E.P. J. Helminthol. (2002) [Pubmed]
 
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