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Gene Review

Myh9  -  myosin, heavy polypeptide 9, non-muscle

Mus musculus

Synonyms: C80049, Cellular myosin heavy chain, type A, D0Jmb2, E030044M24Rik, Fltn, ...
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Disease relevance of Myh9

  • Localization of Myh9 within the stereocilia raises the possibility that mutations of MYH9 may effect hearing loss though disruption of the stereocilia structure [1].

High impact information on Myh9


Anatomical context of Myh9


Associations of Myh9 with chemical compounds

  • Stimulation of RBL-2H3 m1 mast cells through the IgE receptor with antigen, or through a G protein-coupled receptor with carbachol, leads to the rapid appearance of phosphothreonine in nonmuscle myosin heavy chain II-A (NMHC-IIA) [5].

Other interactions of Myh9

  • Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear [6].
  • In contrast to most cells, cardiac myocytes lack NMHC II-A, and ablation of NMHC II-B results in a heart with 70% fewer myocytes at embryonic day 14.5 (E14.5) than control mice (B+/B- and B+/B+) [7].
  • These data taken together strongly suggest that base-line expression of nonmuscle myosin IIA inhibits osteoclast precursor fusion and that a temporary, cathepsin B-mediated decrease in myosin IIA levels triggers precursor fusion during osteoclastogenesis [8].

Analytical, diagnostic and therapeutic context of Myh9


  1. Expression of Myh9 in the mammalian cochlea: localization within the stereocilia. Mhatre, A.N., Li, Y., Atkin, G., Maghnouj, A., Lalwani, A.K. J. Neurosci. Res. (2006) [Pubmed]
  2. A single class II myosin modulates T cell motility and stopping, but not synapse formation. Jacobelli, J., Chmura, S.A., Buxton, D.B., Davis, M.M., Krummel, M.F. Nat. Immunol. (2004) [Pubmed]
  3. Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family. Golomb, E., Ma, X., Jana, S.S., Preston, Y.A., Kawamoto, S., Shoham, N.G., Goldin, E., Conti, M.A., Sellers, J.R., Adelstein, R.S. J. Biol. Chem. (2004) [Pubmed]
  4. Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. Conti, M.A., Even-Ram, S., Liu, C., Yamada, K.M., Adelstein, R.S. J. Biol. Chem. (2004) [Pubmed]
  5. Calcium-dependent threonine phosphorylation of nonmuscle myosin in stimulated RBL-2H3 mast cells. Buxton, D.B., Adelstein, R.S. J. Biol. Chem. (2000) [Pubmed]
  6. Cloning and developmental expression of nonmuscle myosin IIA (Myh9) in the mammalian inner ear. Mhatre, A.N., Li, J., Kim, Y., Coling, D.E., Lalwani, A.K. J. Neurosci. Res. (2004) [Pubmed]
  7. Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis. Takeda, K., Kishi, H., Ma, X., Yu, Z.X., Adelstein, R.S. Circ. Res. (2003) [Pubmed]
  8. Regulated proteolysis of nonmuscle myosin IIA stimulates osteoclast fusion. McMichael, B.K., Wysolmerski, R.B., Lee, B.S. J. Biol. Chem. (2009) [Pubmed]
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