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Gene Review

Mapk11  -  mitogen-activated protein kinase 11

Mus musculus

Synonyms: MAP kinase 11, MAP kinase p38 beta, MAPK 11, Mitogen-activated protein kinase 11, Mitogen-activated protein kinase p38 beta, ...
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High impact information on Mapk11


Biological context of Mapk11


Anatomical context of Mapk11

  • Our results indicate that p38beta is not required for insulin-stimulated glucose uptake in adipocytes or muscle [8].
  • Glucose uptake in adipocytes and soleus muscle was stimulated by insulin by up to fourfold irrespective of whether tissues were isolated from wild-type or p38beta-null mice [8].
  • E2F1 stability is regulated by a novel-PKC/p38beta MAP kinase signaling pathway during keratinocyte differentiation [5].
  • Both p38alpha and p38beta were highly expressed in brain areas including cerebral cortex, hippocampus, cerebellum, and few nuclei of the brainstem [9].
  • At the subcellular level, p38alpha was distributed in dendrites and in cytoplasmic and nuclear regions of cell body of neurons, which is in contrast to p38beta, since p38beta was preferentially expressed in nucleus of neurons [9].

Associations of Mapk11 with chemical compounds

  • Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1 [3].
  • Intraperitoneal injection of SB202190, an inhibitor of p38alpha and p38beta MAPK activity, markedly increased the ability of DN-14-3-3 mice to compensate for pressure overload, with decreased mortality [10].
  • Consistent with this finding, mice lacking p38beta exhibited normal glucose tolerance, insulinemia, and glycemia compared with their wild-type counterparts [8].
  • Although insulin also failed to induce any detectable activation of p38 MAPK in muscle, insulin-dependent glucose uptake was reduced by SB 203580 (approximately 44%) in muscle of both wild-type and p38beta-null mice [8].
  • The induction of p38beta was sustained for more than 10 days after KA-treatment [11].

Enzymatic interactions of Mapk11


Other interactions of Mapk11

  • 17beta-E significantly down-regulated JNK and p38alpha activities, whereas I/R-I promoted p38beta and ERK activation [4].
  • The immunoreactivities of p38alpha and p38beta MAPKs were markedly increased in the brain 4 days after KA administration, especially in the areas undergoing selective neuronal loss [11].
  • By using dominant negative mutants and mice deficient in the genes for the various MAP kinases, we demonstrate that the cytoprotective effects of CO are mediated by selective activation of the MKK3/p38 beta protein MAP kinase pathway [12].

Analytical, diagnostic and therapeutic context of Mapk11


  1. The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. Zhang, S., Weinheimer, C., Courtois, M., Kovacs, A., Zhang, C.E., Cheng, A.M., Wang, Y., Muslin, A.J. J. Clin. Invest. (2003) [Pubmed]
  2. Generation and characterization of p38beta (MAPK11) gene-targeted mice. Beardmore, V.A., Hinton, H.J., Eftychi, C., Apostolaki, M., Armaka, M., Darragh, J., McIlrath, J., Carr, J.M., Armit, L.J., Clacher, C., Malone, L., Kollias, G., Arthur, J.S. Mol. Cell. Biol. (2005) [Pubmed]
  3. Heat shock protein-70 mediates the cytoprotective effect of carbon monoxide: involvement of p38 beta MAPK and heat shock factor-1. Kim, H.P., Wang, X., Zhang, J., Suh, G.Y., Benjamin, I.J., Ryter, S.W., Choi, A.M. J. Immunol. (2005) [Pubmed]
  4. 17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice. Vilatoba, M., Eckstein, C., Bilbao, G., Frennete, L., Eckhoff, D.E., Contreras, J.L. Transplant. Proc. (2005) [Pubmed]
  5. E2F1 stability is regulated by a novel-PKC/p38beta MAP kinase signaling pathway during keratinocyte differentiation. Ivanova, I.A., D'Souza, S.J., Dagnino, L. Oncogene (2006) [Pubmed]
  6. Exip, a new alternative splicing variant of p38 alpha, can induce an earlier onset of apoptosis in HeLa cells. Sudo, T., Yagasaki, Y., Hama, H., Watanabe, N., Osada, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  7. Regulation of activating transcription factor-2 in early stage of the adipocyte differentiation program. Lee, M.Y., Kong, H.J., Cheong, J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  8. Insulin-stimulated glucose uptake does not require p38 mitogen-activated protein kinase in adipose tissue or skeletal muscle. Turban, S., Beardmore, V.A., Carr, J.M., Sakamoto, K., Hajduch, E., Arthur, J.S., Hundal, H.S. Diabetes (2005) [Pubmed]
  9. Constitutive activity and differential localization of p38alpha and p38beta MAPKs in adult mouse brain. Lee, S.H., Park, J., Che, Y., Han, P.L., Lee, J.K. J. Neurosci. Res. (2000) [Pubmed]
  10. Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival. Zhang, S., Ren, J., Zhang, C.E., Treskov, I., Wang, Y., Muslin, A.J. Circ. Res. (2003) [Pubmed]
  11. Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure. Che, Y., Yu, Y.M., Han, P.L., Lee, J.K. Brain Res. Mol. Brain Res. (2001) [Pubmed]
  12. MKK3 mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. Otterbein, L.E., Otterbein, S.L., Ifedigbo, E., Liu, F., Morse, D.E., Fearns, C., Ulevitch, R.J., Knickelbein, R., Flavell, R.A., Choi, A.M. Am. J. Pathol. (2003) [Pubmed]
  13. MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo. Degousee, N., Martindale, J., Stefanski, E., Cieslak, M., Lindsay, T.F., Fish, J.E., Marsden, P.A., Thuerauf, D.J., Glembotski, C.C., Rubin, B.B. Circ. Res. (2003) [Pubmed]
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