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Gene Review

Ptpn13  -  protein tyrosine phosphatase, non-receptor...

Mus musculus

Synonyms: AI324989, PTP-BL, PTP36, PTPL1, Protein tyrosine phosphatase DPZPTP, ...
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Disease relevance of Ptpn13


High impact information on Ptpn13


Biological context of Ptpn13


Anatomical context of Ptpn13

  • PTP-BL phosphatase deficiency did not affect retinal ganglion cell survival in retinal cultures from lens-lesioned mice, though activated retinal glia numbers were significantly reduced in cultures from lens-lesioned PTP-BLDeltaP mice compared to lens-lesioned wildtypes [10].
  • These data suggest a cell cortical localization for PTP-BL in epithelial cells and a possible role in the morphology and motility of epithelial tissues [6].
  • The change of PTP36 expression level along with T cell maturation suggests its involvement in the regulation of T cell development [11].
  • Here we report the cDNA cloning of a non-receptor type protein tyrosine phosphatase, PTP36, which is expressed in murine thymus [11].

Associations of Ptpn13 with chemical compounds

  • Our findings exclude an essential role for PTP-BL as a phosphotyrosine phosphatase and rather are in line with a role as scaffolding or anchoring molecule [8].

Physical interactions of Ptpn13


Other interactions of Ptpn13


Analytical, diagnostic and therapeutic context of Ptpn13


  1. No evidence for involvement of mouse protein-tyrosine phosphatase-BAS-like Fas-associated phosphatase-1 in Fas-mediated apoptosis. Cuppen, E., Nagata, S., Wieringa, B., Hendriks, W. J. Biol. Chem. (1997) [Pubmed]
  2. Subcellular localization and differentiation-induced redistribution of the protein tyrosine phosphatase PTP-BL in Neuroblastoma cells. van Ham, M., Kemperman, L., Wijers, M., Fransen, J., Hendriks, W. Cell. Mol. Neurobiol. (2005) [Pubmed]
  3. EphrinB phosphorylation and reverse signaling: regulation by Src kinases and PTP-BL phosphatase. Palmer, A., Zimmer, M., Erdmann, K.S., Eulenburg, V., Porthin, A., Heumann, R., Deutsch, U., Klein, R. Mol. Cell (2002) [Pubmed]
  4. The Adenomatous Polyposis Coli-protein (APC) interacts with the protein tyrosine phosphatase PTP-BL via an alternatively spliced PDZ domain. Erdmann, K.S., Kuhlmann, J., Lessmann, V., Herrmann, L., Eulenburg, V., Müller, O., Heumann, R. Oncogene (2000) [Pubmed]
  5. Structure, dynamics and binding characteristics of the second PDZ domain of PTP-BL. Walma, T., Spronk, C.A., Tessari, M., Aelen, J., Schepens, J., Hendriks, W., Vuister, G.W. J. Mol. Biol. (2002) [Pubmed]
  6. Molecular cloning of a mouse epithelial protein-tyrosine phosphatase with similarities to submembranous proteins. Hendriks, W., Schepens, J., Bächner, D., Rijss, J., Zeeuwen, P., Zechner, U., Hameister, H., Wieringa, B. J. Cell. Biochem. (1995) [Pubmed]
  7. The gene (PTPN13) encoding the protein tyrosine phosphatase PTP-BL/PTP-BAS is located in mouse chromosome region 5E/F and human chromosome region 4q21. van den Maagdenberg, A.M., Olde Weghuis, D., Rijss, J., Merkx, G.F., Wieringa, B., Geurts van Kessel, A., Hendriks, W.J. Cytogenet. Cell Genet. (1996) [Pubmed]
  8. Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity. Wansink, D.G., Peters, W., Schaafsma, I., Sutmuller, R.P., Oerlemans, F., Adema, G.J., Wieringa, B., van der Zee, C.E., Hendriks, W. Physiol. Genomics (2004) [Pubmed]
  9. The protein tyrosine phosphatase PTP-Basophil/Basophil-like. Interacting proteins and molecular functions. Erdmann, K.S. Eur. J. Biochem. (2003) [Pubmed]
  10. Effects of LAR and PTP-BL phosphatase deficiency on adult mouse retinal cells activated by lens injury. Lorber, B., Hendriks, W.J., Van der Zee, C.E., Berry, M., Logan, A. Eur. J. Neurosci. (2005) [Pubmed]
  11. cDNA cloning of a novel protein tyrosine phosphatase with homology to cytoskeletal protein 4.1 and its expression in T-lineage cells. Sawada, M., Ogata, M., Fujino, Y., Hamaoka, T. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
  12. Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. van Ham, M., Croes, H., Schepens, J., Fransen, J., Wieringa, B., Hendriks, W. Genes Cells (2003) [Pubmed]
  13. The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain. van den Berk, L.C., van Ham, M.A., te Lindert, M.M., Walma, T., Aelen, J., Vuister, G.W., Hendriks, W.J. Mol. Biol. Rep. (2004) [Pubmed]
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