The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ptpro  -  protein tyrosine phosphatase, receptor...

Mus musculus

Synonyms: D28, GLEPP1, Glomerular epithelial protein 1, PTP-BK, PTP-U2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Ptpro


Biological context of Ptpro


Anatomical context of Ptpro

  • Mouse PTPRO mRNA is expressed exclusively in two cell types: neurons and kidney podocytes [5].
  • Expression of PTP phi mRNA is low and restricted to macrophage cell lines, macrophage-rich tissues, and brain, kidney, and heart [3].
  • In adult human and rabbit kidneys, GLEPP1 is found exclusively on apical membranes of podocytes and especially on surfaces of foot processes [6].
  • Expression of PTPRO was also observed in human CD34+ bone marrow cells and 5-FU-treated murine primitive stem cells [7].

Associations of Ptpro with chemical compounds


Other interactions of Ptpro

  • Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons [5].
  • The biochemical complexity and neuronal expression pattern of NPCD, together with its interaction with PTPRO, suggests involvement in multiple neuronal processes [9].


  1. Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O. Shintani, T., Ihara, M., Sakuta, H., Takahashi, H., Watakabe, I., Noda, M. Nat. Neurosci. (2006) [Pubmed]
  2. Altered podocyte structure in GLEPP1 (Ptpro)-deficient mice associated with hypertension and low glomerular filtration rate. Wharram, B.L., Goyal, M., Gillespie, P.J., Wiggins, J.E., Kershaw, D.B., Holzman, L.B., Dysko, R.C., Saunders, T.L., Samuelson, L.C., Wiggins, R.C. J. Clin. Invest. (2000) [Pubmed]
  3. A heteromorphic protein-tyrosine phosphatase, PTP phi, is regulated by CSF-1 in macrophages. Pixley, F.J., Lee, P.S., Dominguez, M.G., Einstein, D.B., Stanley, E.R. J. Biol. Chem. (1995) [Pubmed]
  4. Isolation and characterization of murine orthologue of PTP-BK. Tomemori, T., Seki, N., Suzuki, Y., Shimizu, T., Nagata, H., Konno, A., Shirasawa, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  5. Expression of PTPRO during mouse development suggests involvement in axonogenesis and differentiation of NT-3 and NGF-dependent neurons. Beltran, P.J., Bixby, J.L., Masters, B.A. J. Comp. Neurol. (2003) [Pubmed]
  6. Molecular cloning, expression, and distribution of glomerular epithelial protein 1 in developing mouse kidney. Wang, R., St John, P.L., Kretzler, M., Wiggins, R.C., Abrahamson, D.R. Kidney Int. (2000) [Pubmed]
  7. Characterization and chromosomal localization of PTPRO, a novel receptor protein tyrosine phosphatase, expressed in hematopoietic stem cells. Avraham, S., London, R., Tulloch, G.A., Ellis, M., Fu, Y., Jiang, S., White, R.A., Painter, C., Steinberger, A.A., Avraham, H. Gene (1997) [Pubmed]
  8. A novel substrate of receptor tyrosine phosphatase PTPRO is required for nerve growth factor-induced process outgrowth. Chen, B., Bixby, J.L. J. Neurosci. (2005) [Pubmed]
  9. Neuronal pentraxin with chromo domain (NPCD) is a novel class of protein expressed in multiple neuronal domains. Chen, B., Bixby, J.L. J. Comp. Neurol. (2005) [Pubmed]
WikiGenes - Universities