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Gene Review

Snap91  -  synaptosomal-associated protein 91

Mus musculus

Synonyms: 91 kDa synaptosomal-associated protein, 91kDa, AP180, Clathrin coat assembly protein AP180, Clathrin coat-associated protein AP180, ...
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Disease relevance of Snap91

  • These monoclonal antibodies also specifically recognize the cloned F1-20 protein expressed in Escherichia coli [1].
  • The clathrin assembly protein lymphoid myeloid leukemia (CALM) gene, encodes a homologoue of the neuronal clathrin assembly protein AP180 [2].

Psychiatry related information on Snap91


High impact information on Snap91


Biological context of Snap91

  • Clathrin-mediated endocytosis was selectively blocked with tyrphostin A23, which disrupts the interaction between tyrosine motifs in the cytosolic domains of integral membrane proteins and the adaptor complex AP2, and a dominant-negative mutant of the adaptor protein AP180 [6].
  • We found two distinct isoforms of F1-20 cDNA that differed by the presence of 15 additional nucleotides, which does not interrupt the open reading frame [7].
  • It is likely that the two F1-20 mRNA isoforms are derived from RNA splicing events utilizing alternative 3' acceptor sites [7].
  • Analysis of the deduced amino acid sequence for the complete open reading frame revealed that the predominant F1-20 mRNA encodes an 896 amino acid polypeptide with a molecular weight of 91,319 Da [7].

Anatomical context of Snap91

  • Another monoclonal antibody, F1-20, stains different brain gray matter regions to varying degrees but shows a complete and exclusive exclusion of staining from the globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata [8].
  • These results indicate that a protein with homology to the neuron-specific coated vesicle protein AP180, is present in muscle cells associated with vesicles showing significant concentration around postsynaptic nuclei present in close proximity to AChR clusters [9].

Associations of Snap91 with chemical compounds


Other interactions of Snap91

  • This indicates that the F1-20 protein is a substrate for neuronal calpain [7].
  • We observed that treatment of a synaptosomal lysate with alkaline phosphatase led to an increase in the electrophoretic mobility of the F1-20 protein, as well as to an increase in the sharpness of the electrophoretic band [7].
  • In this study, we show that polarized epithelial Madin-Darby canine kidney (MDCK) cells express two AP180-related proteins: the ubiquitously expressed 62-kDa clathrin assembly lymphoid myeloid leukemia (CALM, AP180-2) protein and a novel high-molecular-weight homolog that we have named AP180-3 [11].

Analytical, diagnostic and therapeutic context of Snap91


  1. The synapse-specific phosphoprotein F1-20 is identical to the clathrin assembly protein AP-3. Zhou, S., Tannery, N.H., Yang, J., Puszkin, S., Lafer, E.M. J. Biol. Chem. (1993) [Pubmed]
  2. Properties of GST-CALM expressed in E. coli. Kim, J.A., Kim, S.R., Jung, Y.K., Woo, S.Y., Seoh, J.Y., Hong, Y.S., Kim, H.L. Exp. Mol. Med. (2000) [Pubmed]
  3. Clathrin assembly protein AP-2 is detected in both neurons and glia, and its reduction is prominent in layer II of frontal cortex in Alzheimer's disease. Yao, P.J., Weimer, J.M., O'Herron, T.M., Coleman, P.D. Neurobiol. Aging (2000) [Pubmed]
  4. Clathrin assembly protein AP180: primary structure, domain organization and identification of a clathrin binding site. Morris, S.A., Schröder, S., Plessmann, U., Weber, K., Ungewickell, E. EMBO J. (1993) [Pubmed]
  5. A role for the clathrin assembly domain of AP180 in synaptic vesicle endocytosis. Morgan, J.R., Zhao, X., Womack, M., Prasad, K., Augustine, G.J., Lafer, E.M. J. Neurosci. (1999) [Pubmed]
  6. Assigning functions to distinct regions of the N-terminus of the prion protein that are involved in its copper-stimulated, clathrin-dependent endocytosis. Taylor, D.R., Watt, N.T., Perera, W.S., Hooper, N.M. J. Cell. Sci. (2005) [Pubmed]
  7. Characterization of a novel synapse-specific protein. II. cDNA cloning and sequence analysis of the F1-20 protein. Zhou, S., Sousa, R., Tannery, N.H., Lafer, E.M. J. Neurosci. (1992) [Pubmed]
  8. Two new monoclonal antibodies provide immunohistochemical evidence for the unique biochemical similarity of the mouse globus pallidus, entopeduncular nucleus and substantia nigra pars reticulata. Sousa, R., Hrinya Tannery, N., Lafer, E.M. Neuroscience (1990) [Pubmed]
  9. A novel AP180-related protein in vesicles that concentrate at acetylcholine receptor clusters. Bursztajn, S., Vincent, S., Brodsky, F.M., Benes, F., Morris, S.A. J. Cell. Biochem. (1998) [Pubmed]
  10. Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus. Berryman, S., Clark, S., Monaghan, P., Jackson, T. J. Virol. (2005) [Pubmed]
  11. Potential role for a novel AP180-related protein during endocytosis in MDCK cells. Kusner, L., Carlin, C. Am. J. Physiol., Cell Physiol. (2003) [Pubmed]
  12. Characterization of a novel synapse-specific protein. I. Developmental expression and cellular localization of the F1-20 protein and mRNA. Sousa, R., Tannery, N.H., Zhou, S., Lafer, E.M. J. Neurosci. (1992) [Pubmed]
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