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Gene Review

Fcer1g  -  Fc receptor, IgE, high affinity I, gamma...

Mus musculus

Synonyms: AI573376, CD23, Fc receptor gamma-chain, Fc-epsilon RI-gamma, FcR-gamma, ...
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Disease relevance of Fcer1g


High impact information on Fcer1g

  • The FcalphaRI alpha chain lacks canonical signal transduction domains but can associate with the FcR gamma-chain that bears an activation motif (ITAM) in the cytoplasmic domain, allowing activatory functions [4].
  • The type-II transmembrane lectin CD23 is expressed in the mouse on B cells and follicular dendritic cells [5].
  • Here we disrupt the gene coding for murine CD23 (ref. 9) to clarify the role of CD23 in vivo and find that B- and T-cell development is normal in these CD23-deficient mice [5].
  • CD23 has been implicated in cellular adhesion, antigen presentation, as a growth and differentiation factor for human B, T and plasma cells, and as a signal transduction molecule (reviewed in refs 3, 8) [5].
  • In addition, FcR-gamma chain-deficient mice were found to express partially functional FcgammaRI [6].

Chemical compound and disease context of Fcer1g


Biological context of Fcer1g


Anatomical context of Fcer1g

  • IL-10 did not upregulate the expression of Fc epsilon receptors (CD23) or class I MHC antigens on small dense B cells or induce their replication as monitored by [3H]thymidine incorporation [15].
  • Unexpectedly, the TCR levels of mature T cells in FcR gamma TG zeta KO mice were lower than those of controls [16].
  • Therefore, the nonreactivity of the FcR gamma + lymphocytes in the gut or in tumor-bearing mice must be caused by some other phenomenon [16].
  • The results demonstrate that expression of GPVI is up-regulated along with the FcR gamma-chain during differentiation of megakaryocytes [17].
  • In a previous study we found that if a chronic T-cell-mediated antigen-induced arthritis (AIA) was elicited in knee joints of FcR gamma-chain-deficient mice that lack functional Fc gamma RI and Fc gamma RIII, joint inflammation was comparable but severe cartilage destruction was absent [18].

Associations of Fcer1g with chemical compounds

  • Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling [19].
  • In Brij 35 lysates, FcR gamma-chain was found to constitutively associate with GPIb [19].
  • These stable transfectants released serotonin in response to cross-linkage of Fc epsilon RI, demonstrating that the molecular defect of p161+/Fc epsilon RI- mast cells is indeed the loss of Fc epsilon RI gamma expression [20].
  • Thus, the mitogenic effect of rDiAg was not due to LPS contamination. rDiAg also enhanced levels of CD23 expression on splenic B cells [21].
  • These results have led to the hypothesis that collagen responses mediated by GPVI-Fc Rgamma may require the collagen-binding integrin alpha2beta1 as a co-receptor, but this model has not been supported by a recent study of mouse platelets lacking alpha2beta1 [22].
  • FcgammaRIII binds E. coli, and this interaction induces FcRgamma phosphorylation, recruitment of the tyrosine phosphatase SHP-1 and phosphatidylinositide-3 kinase (PI3K) dephosphorylation [23].

Physical interactions of Fcer1g


Regulatory relationships of Fcer1g

  • GPVI is a 62-kDa membrane glycoprotein expressed in noncovalent association with the Fc receptor gamma chain on human and murine platelets and serves as the major activating receptor for collagen [28].
  • Moreover, IL-4 production induced by means of passive IgE sensitization and abrogated in FcR gamma-chain-deficient mice supports the conclusion that this IL-4 production is dependent on IgE/gamma-chain interaction [29].
  • First, spleen cells from older lpr mice had an increase in the number and percentage of IgM+ B cells expressing low levels of CD23 [30].
  • We fine that day 14.5 CD4-CD8- double-negative (DN) fetal thymocytes of Fc epsilon RI gamma-/- mice express mRNA of both Fc gamma RIIb1 and Fc gamma RIII [31].
  • Conversely, experimental graft-versus-host disease induced in Fc receptor gamma-chain-deficient mice showed LPG-like lesions in glomeruli without apoE mutations [32].

Other interactions of Fcer1g


Analytical, diagnostic and therapeutic context of Fcer1g


  1. Possible role of autoantibodies in the pathophysiology of GM2 gangliosidoses. Yamaguchi, A., Katsuyama, K., Nagahama, K., Takai, T., Aoki, I., Yamanaka, S. J. Clin. Invest. (2004) [Pubmed]
  2. Fc gamma Rs modulate cytotoxicity of anti-Fas antibodies: implications for agonistic antibody-based therapeutics. Xu, Y., Szalai, A.J., Zhou, T., Zinn, K.R., Chaudhuri, T.R., Li, X., Koopman, W.J., Kimberly, R.P. J. Immunol. (2003) [Pubmed]
  3. Platelets activated by collagen through the immunoreceptor tyrosine-based activation motif in the Fc receptor gamma-chain play a pivotal role in the development of myocardial ischemia-reperfusion injury. Takaya, N., Katoh, Y., Iwabuchi, K., Hayashi, I., Konishi, H., Itoh, S., Okumura, K., Ra, C., Nagaoka, I., Daida, H. J. Mol. Cell. Cardiol. (2005) [Pubmed]
  4. IgA Fc receptors. Monteiro, R.C., Van De Winkel, J.G. Annu. Rev. Immunol. (2003) [Pubmed]
  5. Negative feedback regulation of IgE synthesis by murine CD23. Yu, P., Kosco-Vilbois, M., Richards, M., Köhler, G., Lamers, M.C. Nature (1994) [Pubmed]
  6. FcgammaRI-deficient mice show multiple alterations to inflammatory and immune responses. Barnes, N., Gavin, A.L., Tan, P.S., Mottram, P., Koentgen, F., Hogarth, P.M. Immunity (2002) [Pubmed]
  7. C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma-chain-associated signaling pathway and by agglutination. Tulasne, D., Judd, B.A., Johansen, M., Asazuma, N., Best, D., Brown, E.J., Kahn, M., Koretzky, G.A., Watson, S.P. Blood (2001) [Pubmed]
  8. In chronic idiopathic urticaria autoantibodies against Fc epsilonRII/CD23 induce histamine release via eosinophil activation. Puccetti, A., Bason, C., Simeoni, S., Millo, E., Tinazzi, E., Beri, R., Peterlana, D., Zanoni, G., Senna, G., Corrocher, R., Lunardi, C. Clin. Exp. Allergy (2005) [Pubmed]
  9. Characterization of a complement receptor 2 (CR2, CD21) ligand binding site for C3. An initial model of ligand interaction with two linked short consensus repeat modules. Molina, H., Perkins, S.J., Guthridge, J., Gorka, J., Kinoshita, T., Holers, V.M. J. Immunol. (1995) [Pubmed]
  10. The role of CD23 on allergen-induced IgE levels, pulmonary eosinophilia and bronchial hyperresponsiveness in mice. Riffo-Vasquez, Y., Spina, D., Thomas, M., Gilbey, T., Kemeny, D.M., Page, C.P. Clin. Exp. Allergy (2000) [Pubmed]
  11. Fyn and Lyn phosphorylate the Fc receptor gamma chain downstream of glycoprotein VI in murine platelets, and Lyn regulates a novel feedback pathway. Quek, L.S., Pasquet, J.M., Hers, I., Cornall, R., Knight, G., Barnes, M., Hibbs, M.L., Dunn, A.R., Lowell, C.A., Watson, S.P. Blood (2000) [Pubmed]
  12. IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice. Wernersson, S., Karlsson, M.C., Dahlström, J., Mattsson, R., Verbeek, J.S., Heyman, B. J. Immunol. (1999) [Pubmed]
  13. Cellular requirements of IgE-antibody regulation. König, W., Pfeil, P., Hofmann, U., Bujanowski-Weber, J., Knöller, I. Allergologia et immunopathologia. (1988) [Pubmed]
  14. Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains. Dombrowicz, D., Flamand, V., Miyajima, I., Ravetch, J.V., Galli, S.J., Kinet, J.P. J. Clin. Invest. (1997) [Pubmed]
  15. Interleukin 10, a novel B cell stimulatory factor: unresponsiveness of X chromosome-linked immunodeficiency B cells. Go, N.F., Castle, B.E., Barrett, R., Kastelein, R., Dang, W., Mosmann, T.R., Moore, K.W., Howard, M. J. Exp. Med. (1990) [Pubmed]
  16. Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma. Liu, C.P., Lin, W.J., Huang, M., Kappler, J.W., Marrack, P. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  17. Expression of the collagen receptor glycoprotein VI during megakaryocyte differentiation. Berlanga, O., Bobe, R., Becker, M., Murphy, G., Leduc, M., Bon, C., Barry, F.A., Gibbins, J.M., Garcia, P., Frampton, J., Watson, S.P. Blood (2000) [Pubmed]
  18. Role of activatory Fc gamma RI and Fc gamma RIII and inhibitory Fc gamma RII in inflammation and cartilage destruction during experimental antigen-induced arthritis. van Lent, P.L., Nabbe, K., Blom, A.B., Holthuysen, A.E., Sloetjes, A., van de Putte, L.B., Verbeek, S., van den Berg, W.B. Am. J. Pathol. (2001) [Pubmed]
  19. Role of Fc receptor gamma-chain in platelet glycoprotein Ib-mediated signaling. Wu, Y., Suzuki-Inoue, K., Satoh, K., Asazuma, N., Yatomi, Y., Berndt, M.C., Ozaki, Y. Blood (2001) [Pubmed]
  20. Mast cells lacking the high affinity immunoglobulin E receptor are deficient in Fc epsilon RI gamma messenger RNA. Ryan, J.J., Kinzer, C.A., Paul, W.E. J. Exp. Med. (1995) [Pubmed]
  21. Recombinant Dirofilaria immitis polyprotein that stimulates murine B cells to produce nonspecific polyclonal immunoglobulin E antibody. Tezuka, H., Imai, S., Muto, R., Furuhashi, Y., Fujita, K. Infect. Immun. (2002) [Pubmed]
  22. The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion. Chen, H., Locke, D., Liu, Y., Liu, C., Kahn, M.L. J. Biol. Chem. (2002) [Pubmed]
  23. CD16 promotes Escherichia coli sepsis through an FcR gamma inhibitory pathway that prevents phagocytosis and facilitates inflammation. Pinheiro da Silva, F., Aloulou, M., Skurnik, D., Benhamou, M., Andremont, A., Velasco, I.T., Chiamolera, M., Verbeek, J.S., Launay, P., Monteiro, R.C. Nat. Med. (2007) [Pubmed]
  24. Involvement of the interleukin-2 receptor gamma subunit in interleukin-4-dependent activation of mouse hematopoietic cells and splenic B cells. Watanabe, S., Kondo, M., Takatsu, K., Sugamura, K., Arai, K. Eur. J. Immunol. (1995) [Pubmed]
  25. Lipid rafts orchestrate signaling by the platelet receptor glycoprotein VI. Locke, D., Chen, H., Liu, Y., Liu, C., Kahn, M.L. J. Biol. Chem. (2002) [Pubmed]
  26. Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine. Liu, C.P., Ueda, R., She, J., Sancho, J., Wang, B., Weddell, G., Loring, J., Kurahara, C., Dudley, E.C., Hayday, A. EMBO J. (1993) [Pubmed]
  27. A common site of the Fc receptor gamma subunit interacts with the unrelated immunoreceptors FcalphaRI and FcepsilonRI. Wines, B.D., Trist, H.M., Ramsland, P.A., Hogarth, P.M. J. Biol. Chem. (2006) [Pubmed]
  28. Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents. Boylan, B., Berndt, M.C., Kahn, M.L., Newman, P.J. Blood (2006) [Pubmed]
  29. IgE(+), Kit(-), I-A/I-E(-) myeloid cells are the initial source of Il-4 after antigen challenge in a mouse model of allergic pulmonary inflammation. Luccioli, S., Brody, D.T., Hasan, S., Keane-Myers, A., Prussin, C., Metcalfe, D.D. J. Allergy Clin. Immunol. (2002) [Pubmed]
  30. Phenotypic abnormalities of splenic and bone marrow B cells in lpr and gld mice. Reap, E.A., Piecyk, M.L., Oliver, A., Sobel, E.S., Waldschmidt, T., Cohen, P.L., Eisenberg, R.A. Clin. Immunol. Immunopathol. (1996) [Pubmed]
  31. T lymphocyte development in the absence of Fc epsilon receptor I gamma subunit: analysis of thymic-dependent and independent alpha beta and gamma delta pathways. Heiken, H., Schulz, R.J., Ravetch, J.V., Reinherz, E.L., Koyasu, S. Eur. J. Immunol. (1996) [Pubmed]
  32. Impact of lipoprotein glomerulopathy on the relationship between lipids and renal diseases. Saito, T., Matsunaga, A., Oikawa, S. Am. J. Kidney Dis. (2006) [Pubmed]
  33. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase. Mócsai, A., Humphrey, M.B., Van Ziffle, J.A., Hu, Y., Burghardt, A., Spusta, S.C., Majumdar, S., Lanier, L.L., Lowell, C.A., Nakamura, M.C. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  34. TCR isoform containing the Fc receptor gamma chain exhibits structural and functional differences from isoform containing CD3 zeta. Ohno, H., Aoe, T., Ra, C., Yamamoto, T., Saito, T. Int. Immunol. (1993) [Pubmed]
  35. Selective suppression of interleukin-12 induction after macrophage receptor ligation. Sutterwala, F.S., Noel, G.J., Clynes, R., Mosser, D.M. J. Exp. Med. (1997) [Pubmed]
  36. Suppression of IgE responses in CD23-transgenic animals is due to expression of CD23 on nonlymphoid cells. Payet-Jamroz, M., Helm, S.L., Wu, J., Kilmon, M., Fakher, M., Basalp, A., Tew, J.G., Szakal, A.K., Noben-Trauth, N., Conrad, D.H. J. Immunol. (2001) [Pubmed]
  37. Abolition of anti-glomerular basement membrane antibody-mediated glomerulonephritis in FcRgamma-deficient mice. Wakayama, H., Hasegawa, Y., Kawabe, T., Hara, T., Matsuo, S., Mizuno, M., Takai, T., Kikutani, H., Shimokata, K. Eur. J. Immunol. (2000) [Pubmed]
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