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MeSH Review

Sarcoma 180

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Disease relevance of Sarcoma 180

  • Further, implanted tumor growth (sarcoma-180, Lewis lung carcinoma) was markedly suppressed in EP3(-/-), in which tumor-associated angiogenesis was also reduced [1].
  • The growth of Meth A implanted i.m. was also markedly inhibited by rTNF-alpha given i.v. However, the life of mice bearing i.p. Colon 26 adenocarcinoma, MH134 hepatoma, Sarcoma-180, and Ehrlich carcinoma was not prolonged by rTNF-alpha given i.p. nine times (days 1-9) in doses up to 1.0 or 3.2 micrograms/mouse [2].
  • Amongst the acyclonucleoside analogues, the most effective inhibitor of the enzyme from the rat and Ehrlich ascites cells exhibited a Ki = 0.1 microM, comparable to that reported with the Sarcoma-180 enzyme, whereas the Ki for inhibition of the E. coli enzyme was 0.7 microM [3].
  • The antitumor effect of MPEG-TNF-alpha against sarcoma-180 other than Meth-A fibrosarcoma was also about 100 times greater than that of native TNF-alpha when systemically administered [4].
  • Inhibition of carcinosarcoma Walker-256 by 88% and sarcoma-180 by 36% on treatment with 60 mg/kg body weight of hydrazine sulphate was followed by decreases in the rate of acetylation of 39.4 and 29.4%, respectively [5].

High impact information on Sarcoma 180

  • Sarcoma-180 cells implanted in wild-type (WT) mice formed a tumor with extensive angiogenesis, which was greatly suppressed by specific inhibitors for cyclooxygenase (COX)-2 but not for COX-1 [1].
  • DIVEMA-TNF-alpha (+) caused a dramatic hemorrhagic necrotic effect on the tumor when compared to native TNF-alpha 24 h after i.v. injection into mice bearing Sarcoma-180 solid tumors [6].
  • The PVD-conjugated ADR showed superior antitumor activity against sarcoma-180 solid tumor in mice, and it had less toxic side effects than free ADR [7].
  • Parental P388 murine leukemia cell line sensitive to adriamycin, subline of P388 murine leukemia resistant to adriamycin, sarcoma-180 and Ehrlich ascites tumor were employed in this study [8].
  • Pool size studies of the fate of [14C]-CldC in BDF1 mice bearing Sarcoma-180 tumors, which demonstrated the rapid formation of 5-chlorodeoxycytidylate (CldCMP), and incorporation of CldC as such in RIF-1 tumor DNA, indicate that CldC is a substrate for deoxycytidine kinase, as our past Km studies have shown [9].

Chemical compound and disease context of Sarcoma 180


Biological context of Sarcoma 180


Anatomical context of Sarcoma 180


Gene context of Sarcoma 180


Analytical, diagnostic and therapeutic context of Sarcoma 180


  1. Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth. Amano, H., Hayashi, I., Endo, H., Kitasato, H., Yamashina, S., Maruyama, T., Kobayashi, M., Satoh, K., Narita, M., Sugimoto, Y., Murata, T., Yoshimura, H., Narumiya, S., Majima, M. J. Exp. Med. (2003) [Pubmed]
  2. Recombinant human tumor necrosis factor-alpha: evidence of an indirect mode of antitumor activity. Manda, T., Shimomura, K., Mukumoto, S., Kobayashi, K., Mizota, T., Hirai, O., Matsumoto, S., Oku, T., Nishigaki, F., Mori, J. Cancer Res. (1987) [Pubmed]
  3. Inhibitor properties of some 5-substituted uracil acyclonucleosides, and 2,2'-anhydrouridines versus uridine phosphorylase from E. coli and mammalian sources. Drabikowska, A.K., Lissowska, L., Veres, Z., Shugar, D. Biochem. Pharmacol. (1987) [Pubmed]
  4. Molecular design of hybrid tumor necrosis factor-alpha III: polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation. Tsutsumi, Y., Kihira, T., Tsunoda, S., Kamada, H., Nakagawa, S., Kaneda, Y., Kanamori, T., Mayumi, T. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  5. On the relationship between the activity of acetylation, growth of experimental tumors and efficacy of their suppression by hydrazine sulphate. Dilman, V.M., Anisimov, V.N., Kolosov, A.I., Bulovskaya, L.N. Oncology (1976) [Pubmed]
  6. Antitumor activity of tumor necrosis factor alpha conjugated with divinyl ether and maleic anhydride copolymer on solid tumors in mice. Kaneda, Y., Yamamoto, Y., Kamada, H., Tsunoda, S., Tsutsumi, Y., Hirano, T., Mayumi, T. Cancer Res. (1998) [Pubmed]
  7. Design of a pH-sensitive polymeric carrier for drug release and its application in cancer therapy. Kamada, H., Tsutsumi, Y., Yoshioka, Y., Yamamoto, Y., Kodaira, H., Tsunoda, S., Okamoto, T., Mukai, Y., Shibata, H., Nakagawa, S., Mayumi, T. Clin. Cancer Res. (2004) [Pubmed]
  8. Effect of alterations in permeability by nonionic surfactants on adriamycin cytotoxicity in murine tumor models in vitro. Parekh, H.K., Chitnis, M.P. Oncology (1990) [Pubmed]
  9. Radiation, pool size and incorporation studies in mice with 5-chloro-2'-deoxycytidine. Santos, O., Perez, L.M., Briggle, T.V., Boothman, D.A., Greer, S.B. Int. J. Radiat. Oncol. Biol. Phys. (1990) [Pubmed]
  10. Sodium succinate enhances the colorimetric reaction of the in vitro chemosensitivity test: MTT assay. Maehara, Y., Kusumoto, T., Kusumoto, H., Anai, H., Sugimachi, K. Oncology (1988) [Pubmed]
  11. Inhibition of uridine transport through sarcoma-180 cell membrane by anthracycline antibiotics. Choudhury, S.R., Deb, J.K., Choudhury, K., Neogy, R.K. Biochem. Pharmacol. (1982) [Pubmed]
  12. The effects of an algal polysaccharide from Gloiopeltis tenax on transplantable tumors and immune activities in mice. Ren, D.L., Wang, J.Z., Noda, H., Amano, H., Ogawa, S. Planta Med. (1995) [Pubmed]
  13. The antitumor effect of hyperthermia combined with fluorouracil and its analogues. Harada, S., Ping, L., Obara, T., Oikawa, H., Miyata, M., Matsuo, M., Takahashi, T., Yanagisawa, T. Radiat. Res. (1995) [Pubmed]
  14. Effect of cisplatin on the plasma membrane phosphatase activities in ascites sarcoma-180 cells: a cytochemical study. Aggarwal, S.K., Niroomand-Rad, I. J. Histochem. Cytochem. (1983) [Pubmed]
  15. Ag-NOR staining in mouse sarcoma ascites cells. Chaudhuri, A., Ghosh, S. J. Cancer Res. Clin. Oncol. (1983) [Pubmed]
  16. Cytotoxic activities of acetoxyscirpenediol and ergosterol peroxide from Paecilomyces tenuipes. Nam, K.S., Jo, Y.S., Kim, Y.H., Hyun, J.W., Kim, H.W. Life Sci. (2001) [Pubmed]
  17. Tween-80 alters natural resistance of sarcoma-180 to bouvardin (NSC 259968). Menon, R., Chitnis, M., Adwankar, M., Basrur, V., Amonkar, A. Tumori. (1984) [Pubmed]
  18. Effect of a soluble alpha-D-glucan from the lichenized fungus Ramalina celastri on macrophage activity. Stuelp-Campelo, P.M., de Oliveira, M.B., Leão, A.M., Carbonero, E.R., Gorin, P.A., Iacomini, M. Int. Immunopharmacol. (2002) [Pubmed]
  19. Suppressive factor against macrophage phagocytosis produced by cultured sarcoma-180 cells. Saito, H., Tomioka, H. Gann = Gan. (1979) [Pubmed]
  20. Effects of Phytolacca acinosa polysaccharides I with different schedules on its antitumor efficiency in tumor bearing mice and production of IL-1, IL-2, IL-6, TNF, CSF activity in normal mice. Wang, H.B., Zheng, Q.Y. Immunopharmacology and immunotoxicology. (1997) [Pubmed]
  21. Chemical structure and biological activity of water-soluble polysaccharides from Cassia angustifolia leaves. Müller, B.M., Kraus, J., Franz, G. Planta Med. (1989) [Pubmed]
  22. Antiproliferative activity of contragestazol (DL111-IT) in murine and human tumor models in vitro and in vivo. Yang, B., He, Q.J., Zhu, D.Y., Lou, Y.J., Fang, R.Y. Cancer Chemother. Pharmacol. (2006) [Pubmed]
  23. Laser flow cytometric studies on the intracellular accumulation of anthracyclines when combined with heat. Sakaguchi, Y., Maehara, Y., Inutsuka, S., Takahashi, I., Yoshida, M., Emi, Y., Baba, H., Sugimachi, K. Cancer Chemother. Pharmacol. (1994) [Pubmed]
  24. Antitumor effect of a calmodulin antagonist on the growth of solid sarcoma-180. Ito, H., Hidaka, H. Cancer Lett. (1983) [Pubmed]
  25. Immunological and antitumor effects of coumarin and some derivatives. Rosskopf, F., Kraus, J., Franz, G. Die Pharmazie. (1992) [Pubmed]
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