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Gene Review

STK38L  -  serine/threonine kinase 38 like

Homo sapiens

Synonyms: KIAA0965, NDR2, NDR2 protein kinase, Nuclear Dbf2-related kinase 2, Serine/threonine-protein kinase 38-like
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Disease relevance of STK38L

  • Here we show that the NDR1 and NDR2 kinases were incorporated into HIV-1 particles [1].

High impact information on STK38L


Biological context of STK38L

  • NDR2 is potently activated in cells following treatment with the protein phosphatase 2A inhibitor okadaic acid, which also results in phosphorylation on the activation segment residue Ser-282 and the hydrophobic motif residue Thr-442 [4].
  • Since several virion-incorporated kinases regulate the infectivity of human immunodeficiency virus type 1 (HIV-1), we speculated that the human NDR1 and NDR2 kinases might play a role in the HIV-1 life cycle [1].

Anatomical context of STK38L

  • However, they differ in expression pattern; mouse Ndr1 is expressed mainly in spleen, lung and thymus, whereas mouse Ndr2 shows highest expression in the gastrointestinal tract [4].
  • NDR2 is expressed in most human tissues with the highest expression in the thymus [5].
  • Thus, to identify proteins that interact with NDR1 or NDR2, epitope-tagged kinases were immunoprecipitated from Jurkat T-cells [5].
  • In accordance with its zebrafish orthologue, Spaw is expressed as the first asymmetric marker in the left lateral plate mesoderm (LPM) and Ndr2 displays asymmetric expression domains in the brain and the LPM [6].

Associations of STK38L with chemical compounds


Analytical, diagnostic and therapeutic context of STK38L


  1. HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases. Devroe, E., Silver, P.A., Engelman, A. Virology (2005) [Pubmed]
  2. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Stegert, M.R., Hergovich, A., Tamaskovic, R., Bichsel, S.J., Hemmings, B.A. Mol. Cell. Biol. (2005) [Pubmed]
  3. NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling. Suzuki, A., Ogura, T., Esumi, H. J. Biol. Chem. (2006) [Pubmed]
  4. Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein. Stegert, M.R., Tamaskovic, R., Bichsel, S.J., Hergovich, A., Hemmings, B.A. J. Biol. Chem. (2004) [Pubmed]
  5. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases. Devroe, E., Erdjument-Bromage, H., Tempst, P., Silver, P.A. J. Biol. Chem. (2004) [Pubmed]
  6. Dynamic expression pattern of Nodal-related genes during left-right development in medaka. Soroldoni, D., Bajoghli, B., Aghaallaei, N., Czerny, T. Gene Expr. Patterns (2007) [Pubmed]
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