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Gene Review

DNPEP  -  aspartyl aminopeptidase

Homo sapiens

Synonyms: ASPEP, Aspartyl aminopeptidase, DAP
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Disease relevance of DNPEP

  • The histochemistry of DAP II and IV may supplement other histochemical and immunological markers in the cytological classification of lymphomas [1].
  • Variable positivity to DAP II and DAP IV was found in the lymphoblasts in seven cases of acute lymphoblastic leukaemia, in 14 cases of B chronic lymphocytic leukaemia, and in three cases of non-Hodgkin's lymphoma [2].
  • Virtually all of the myeloma cells (96%) all of the myeloma cells (96%) in five cases of multiple myeloma and two cases of plasma cell leukaemia were DAP II positive and DAP IV negative [2].
  • DAP II activity, but not DAP IV activity, was present in all of the mast cells in a case of systemic mastocytosis [2].
  • In the present study, a D-alanyl-D-alanine carboxypeptidase (DAP) mutant of Brucella abortus failed to replicate in mouse macrophages and HeLa cells, and showed less virulence than the wild type in mice [3].

High impact information on DNPEP

  • The relative expression for the aforementioned peptidases, assayed using quantitative RT-PCR, increases in CCRCC for aminopeptidases B (1.5-fold) and A (19-fold), aspartyl-aminopeptidase (3.9-fold), puromycin-sensitive aminopeptidase (2.5-fold), and pyroglutamyl peptidase I (7.6-fold) [4].
  • Aminopeptidase B activity of the particulate fraction in tumors decreases (t = 2,399 vs. n = 13,536 UP/mg protein; P < 0.001) compared with nontumor tissues, and aspartyl-aminopeptidase activity decreases significantly in CCRCC (t = 137 vs. n = 223 UP/mg protein; P < 0.05) [4].
  • DAP also was lower in the gabapentin group 0, 1, 3, and 10 min after intubation [81 (18) vs 104 (19), P=0.0001, 77 (9) vs 91 (16), P=0.001, 71 (10) vs 84 (13), P=0.001 and 67 (10) vs 79 (12), P=0.004] [5].
  • Systolic, diastolic arterial blood pressures (SAP, DAP) and heart rate (HR) were recorded before and after the anaesthetic and 0, 1, 3, 5 and 10 min after tracheal intubation [5].
  • Eight histidine residues of human DAP were sequentially mutated to phenylalanine [6].

Chemical compound and disease context of DNPEP


Anatomical context of DNPEP


Associations of DNPEP with chemical compounds


Other interactions of DNPEP


  1. Histochemistry of dipeptidyl aminopeptidase (DAP) II and IV in reactive lymphoid tissues and malignant lymphoma. Khalaf, M.R., Aqel, N.M., Hayhoe, F.G. J. Clin. Pathol. (1987) [Pubmed]
  2. Comparative cytochemical study of dipeptidyl aminopeptidase (DAP) II and IV in normal and malignant haemic cells. Khalaf, M.R., Bevan, P.C., Hayhoe, F.G. J. Clin. Pathol. (1986) [Pubmed]
  3. Brucella abortusd-alanyl-D-alanine carboxypeptidase contributes to its intracellular replication and resistance against nitric oxide. Kikuchi, H., Kim, S., Watanabe, K., Watarai, M. FEMS Microbiol. Lett. (2006) [Pubmed]
  4. Altered levels of acid, basic, and neutral peptidase activity and expression in human clear cell renal cell carcinoma. Varona, A., Blanco, L., López, J.I., Gil, J., Agirregoitia, E., Irazusta, J., Larrinaga, G. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  5. Gabapentin attenuates the pressor response to direct laryngoscopy and tracheal intubation. Fassoulaki, A., Melemeni, A., Paraskeva, A., Petropoulos, G. British journal of anaesthesia. (2006) [Pubmed]
  6. Identification of histidine residues important in the catalysis and structure of aspartyl aminopeptidase. Wilk, S., Wilk, E., Magnusson, R.P. Arch. Biochem. Biophys. (2002) [Pubmed]
  7. Serum activities of dipeptidyl-aminopeptidase II and dipeptidyl-aminopeptidase IV in tumor-bearing animals and in cancer patients. Kojima, K., Mihara, R., Sakai, T., Togari, A., Matsui, T., Shinpo, K., Fujita, K., Fukasawa, K., Harada, M., Nagatsu, T. Biochem. Med. Metab. Biol. (1987) [Pubmed]
  8. Brain aminopeptidases and hypertension. Banegas, I., Prieto, I., Vives, F., Alba, F., Gasparo, M., Segarra, A.B., Hermoso, F., Dur??n, R., Ram??rez, M. Journal of the renin-angiotensin-aldosterone system : JRAAS (2006) [Pubmed]
  9. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera, M.P., Ramírez-Expósito, M.J., Valenzuela, M.T., Dueñas, B., García, M.J., Mayas, M.D., Martínez-Martos, J.M. Cancer Invest. (2006) [Pubmed]
  10. Activities of some peptidases and glycolytic enzymes in cells of the amniotic fluid. II. Pregnancies complicated by threatening intrauterine fetal asphyxia. Sward, J., Woytoń, J., Ilczyszyn, J., Dobryszycka, W., Narczewska, B., Warwas, M., Woźniak, M. Arch. Immunol. Ther. Exp. (Warsz.) (1977) [Pubmed]
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