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Gene Review

Sult2a6  -  sulfotransferase family 2A,...

Rattus norvegicus

Synonyms: AD-ST, Alcohol sulfotransferase A, Androsterone-sulfating sulfotransferase, Hydroxysteroid sulfotransferase A, RATSMP2A, ...
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Disease relevance of Smp2a


High impact information on Smp2a

  • Major isoenzymes of androsterone-sulphating sulphotransferase (AD-ST) were isolated from liver cytosols of weanling and young adult female rats and their isoelectric properties were compared [2].
  • These results demonstrate that the pI variants of AD-ST are derived from the same precursor by post-translational modification or that they are products of closely related, but distinct, genes [2].
  • The cDNA sequence (saGHF-1/Pit-1) encodes a protein of 371 amino acids (aa) containing a POU domain (aa 194-343) and a transactivation, STA domain (aa 1-128) [3].
  • Addition of DEX to the media resulted in ST-40/41 and ST-60 mRNA expression at 20 and 35% of their initial values, respectively, in cultures maintained on matrigel and Chee's medium at 96 hr [4].
  • Female GH secretory pattern appears to determine the high expression of ST-20/21 in postpubertal female rats, although male GH secretory pattern results in the low expression of ST-40/41 and ST-60 in mature male rats [5].

Biological context of Smp2a


Anatomical context of Smp2a

  • On the other hand, AD-ST is evident in the hepatocytes proximal to the portal triad in males, while in females it is synthesized and localized in all the hepatocytes [10].
  • The lectins MPA and STA may be, therefore, used as the specific markers of malignancy in rat thyroid carcinogenesis [11].

Associations of Smp2a with chemical compounds


Regulatory relationships of Smp2a

  • It has been previously reported that in vivo treatment with CYP1A1 inducer 3-methylcholanthrene (3-MC) suppresses rat hepatic HST-a mRNA expression in a dose-dependent manner [14].

Other interactions of Smp2a


Analytical, diagnostic and therapeutic context of Smp2a


  1. The effect of Escherichia coli heat-stable (STA) enterotoxin on in vitro uptake of amino acids by small intestine of sucking rats during fluid accumulation. Tin-Aung, n.u.l.l., Khin-Maung-U, n.u.l.l., Wai-Wai-Than, n.u.l.l., Thida-Aung, n.u.l.l. Br. J. Nutr. (1993) [Pubmed]
  2. Developmental changes in the isoelectric variants of rat hepatic hydroxysteroid sulphotransferase. Takahashi, M., Homma, H., Matsui, M. Biochem. J. (1993) [Pubmed]
  3. Molecular cloning of gilthead seabream (Sparus aurata) pituitary transcription factor GHF-1/Pit-1. Martínez-Barberá, J.P., Vila, V., Valdivia, M.M., Castrillo, J.L. Gene (1997) [Pubmed]
  4. Sulfotransferase gene expression in primary cultures of rat hepatocytes. Liu, L., LeCluyse, E.L., Liu, J., Klaassen, C.D. Biochem. Pharmacol. (1996) [Pubmed]
  5. Ontogeny and hormonal basis of female-dominant rat hepatic sulfotransferases. Liu, L., Klaassen, C.D. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  6. cDNA cloning of the hydroxysteroid sulfotransferase STa sharing a strong homology in amino acid sequence with the senescence marker protein SMP-2 in rat livers. Ogura, K., Kajita, J., Narihata, H., Watabe, T., Ozawa, S., Nagata, K., Yamazoe, Y., Kato, R. Biochem. Biophys. Res. Commun. (1990) [Pubmed]
  7. Construction and expression of chimeric rat liver hydroxysteroid sulfotransferase isozymes. Tamura, H., Morioka, Y., Homma, H., Matsui, M. Arch. Biochem. Biophys. (1997) [Pubmed]
  8. Regulation of rat hepatic sulfotransferase gene expression by glucocorticoid hormones. Runge-Morris, M., Rose, K., Kocarek, T.A. Drug Metab. Dispos. (1996) [Pubmed]
  9. Properties of androsterone-sulfating sulfotransferase in female rat liver. Homma, H., Sasaki, T., Matsui, M. Chem. Pharm. Bull. (1991) [Pubmed]
  10. Differential localization of sulfotransferase isoenzymes in rat liver. Homma, H., Nakagome, I., Matsui, M. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  11. Lectin histochemistry in rat thyroid tumours. Imamura, Y., Sugihara, H., Miyake, T., Ikeda, T., Noriki, S., Miyoshi, N., Nakanishi, K., Fukuda, M. Basic and applied histochemistry. (1989) [Pubmed]
  12. Studies on rat hepatic hydroxysteroid sulfotransferase--immunochemistry, development and pI variants. Homma, H., Nakagome, I., Kamakura, M., Hirota, M., Takahashi, M., Matsui, M. Chem. Biol. Interact. (1994) [Pubmed]
  13. Site-directed mutagenesis of rat hepatic hydroxysteroid sulfotransferases. Homma, H., Ogawa, K., Hirono, K., Morioka, Y., Hirota, M., Tanahashi, I., Matsui, M. Biochim. Biophys. Acta (1996) [Pubmed]
  14. Regulation of sulfotransferase gene expression by glucocorticoid hormones and xenobiotics in primary rat hepatocyte culture. Runge-Morris, M. Chem. Biol. Interact. (1998) [Pubmed]
  15. On the nature of rat hepatic and mouse olfactory sulfotransferases. Matsui, M., Tamura, H., Nagai, F., Homma, H., Miyawaki, A., Mikoshiba, K. Chem. Biol. Interact. (1998) [Pubmed]
  16. Sulfotransferase gene expression in rat hepatic and extrahepatic tissues. Runge-Morris, M.A. Chem. Biol. Interact. (1994) [Pubmed]
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