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Gene Review

Sult1a1  -  sulfotransferase family, cytosolic, 1A,...

Rattus norvegicus

Synonyms: ASTIV, Aryl sulfotransferase, Aryl sulfotransferase IV, Minoxidil sulfotransferase, Mx-ST, ...
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Disease relevance of Sult1a1

  • A phage genomic clone containing 70% of the 3' AST gene coding sequence was isolated after screening a rat genomic library with an ASTIV cDNA [1].
  • In contrast, mRNA fractions isolated from some 2AAF-induced liver tumors or from known chemical carcinogen-derived rat hepatoma cell lines showed losses of both AST IV transcript level and in vitro translation capacity, suggesting that regulation at the transcriptional level may become important at late stages of 2AAF-induced hepatocarcinogenesis [2].
  • The sulfotransferase employed in these studies was rat hepatic aryl sulfotransferase (AST) IV (also known as tyrosine-ester sulfotransferase, EC, for which a cDNA had been previously cloned and expressed in Escherichia coli and the resulting enzyme purified to homogeneity [3].
  • Hence, in DEN-initiated rats, the effects of promoting regimens of 9-OH-2-FAA or 9-oxo-2-FAA, 15 oral doses at 50 and 100 mumol/kg of body weight, were compared to those of 2-FAA at 50 mumol/kg of body weight and of the vehicle on the activity of N-hydroxy(OH)-2-FAA sulfotransferase (ST), an isozyme of AST IV and AST IV expression and distribution [4].
  • Rat liver N-hydroxy-2-acetylaminofluorene (N-OH-2AAF) sulfotransferase activity is mediated by aryl sulfotransferase IV (AST IV) and causes the bioactivation of N-OH-2AAF to a highly reactive sulfuric acid ester form putatively capable of inducing liver cancer [5].

High impact information on Sult1a1

  • Characterization of a complementary DNA for rat liver aryl sulfotransferase IV and use in evaluating the hepatic gene transcript levels of rats at various stages of 2-acetylaminofluorene-induced hepatocarcinogenesis [2].
  • These results indicated that the molecular mechanisms for the 2AAF-mediated down regulation of AST IV expression during 2AAF-induced hepatocarcinogenesis involved alterations in regulation at both translational and transcriptional levels [2].
  • The AST IV cDNA clone was obtained by immunochemical screening of a male Sprague-Dawley rat liver cDNA library [2].
  • Comparison of the PST-I/AST IV cDNA-deduced amino acid sequence with data from a partial (51%) amino acid sequence analysis of purified AST IV showed complete amino acid homology, confirming the identity of the cDNA and establishing that AST IV was an N-blocked, 291-amino acid protein with a molecular mass of 33,909 daltons [2].
  • The AST IV cDNA sequence differed from the PST-I cDNA in two principal ways: the 5' end lacked 18 coding bases, and the 3' end contained a 190-base extention in the untranslated region, including a consensus sequence for signalling polyadenylation [2].

Chemical compound and disease context of Sult1a1


Biological context of Sult1a1


Anatomical context of Sult1a1


Associations of Sult1a1 with chemical compounds


Other interactions of Sult1a1


Analytical, diagnostic and therapeutic context of Sult1a1

  • The remaining 5' sequence was determined from a PCR product obtained from rat genomic DNA and ASTIV cDNA-specific primers [1].
  • Sequence analysis of the AST IV cDNA showed it to be 1127 residues in length and to have essentially complete homology with PST-I cDNA, a previously reported (S. Ozawa, et al., Nucleic Acids Res., 18: 4001, 1990), 1028-base cDNA for an uncharacterized rat liver aryl sulfotransferase [2].
  • At approximately 8 months after treatment with the C-9-oxidized compounds at doses twice that of 2-FAA, the extents of decreases in the hepatic N-OH-2-FAA ST activity and cytosolic AST IV protein in tumors were comparable to those with 2-FAA [4].
  • Six amino acid residues of PST have been chosen for mutagenesis studies on the basis of a model of PST and its sequence alignment with those of available cytosolic and membrane-anchored STs [20].
  • Northern blot analysis indicated that minoxidil sulfotransferase mRNA is up-regulated in the fasted rat and mouse, ob/ob mouse, and fa/fa rat [11].


  1. Genomic structure of rat liver aryl sulfotransferase IV-encoding gene. Khan, A.S., Taylor, B.R., Chung, K., Etheredge, J., Gonzales, R., Ringer, D.P. Gene (1993) [Pubmed]
  2. Characterization of a complementary DNA for rat liver aryl sulfotransferase IV and use in evaluating the hepatic gene transcript levels of rats at various stages of 2-acetylaminofluorene-induced hepatocarcinogenesis. Yerokun, T., Etheredge, J.L., Norton, T.R., Carter, H.A., Chung, K.H., Birckbichler, P.J., Ringer, D.P. Cancer Res. (1992) [Pubmed]
  3. Affinity labeling of aryl sulfotransferase IV. Identification of a peptide sequence at the binding site for 3'-phosphoadenosine-5'-phosphosulfate. Zheng, Y., Bergold, A., Duffel, M.W. J. Biol. Chem. (1994) [Pubmed]
  4. Aryl sulfotransferase IV deficiency in rat liver carcinogenesis initiated with diethylnitrosamine and promoted with N-2-fluorenylacetamide or its C-9-oxidized metabolites. Malejka-Giganti, D., Ringer, D.P., Vijayaraghavan, P., Kiehlbauch, C.C., Kong, J. Exp. Mol. Pathol. (1997) [Pubmed]
  5. Reaction product inactivation of aryl sulfotransferase IV following electrophilic substitution by the sulfuric acid ester of N-hydroxy-2-acetylaminofluorene. Ringer, D.P., Norton, T.R., Self, R.R. Carcinogenesis (1992) [Pubmed]
  6. Induction of rat hepatic aryl sulfotransferase (SULT1A1) gene expression by triamcinolone acetonide: impact on minoxidil-mediated hypotension. Duanmu, Z., Dunbar, J., Falany, C.N., Runge-Morris, M. Toxicol. Appl. Pharmacol. (2000) [Pubmed]
  7. Nucleotide sequence of a full-length cDNA (PST-1) for aryl sulfotransferase from rat liver. Ozawa, S., Nagata, K., Gong, D.W., Yamazoe, Y., Kato, R. Nucleic Acids Res. (1990) [Pubmed]
  8. Effect of aging on drug-metabolizing enzymes important in acetaminophen elimination. Galinsky, R.E., Kane, R.E., Franklin, M.R. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  9. Regulation of rat hepatic sulfotransferase gene expression by glucocorticoid hormones. Runge-Morris, M., Rose, K., Kocarek, T.A. Drug Metab. Dispos. (1996) [Pubmed]
  10. Sequence analysis, in vitro translation, and expression of the cDNA for rat liver minoxidil sulfotransferase. Hirshey, S.J., Dooley, T.P., Reardon, I.M., Heinrikson, R.L., Falany, C.N. Mol. Pharmacol. (1992) [Pubmed]
  11. Food deprivation-induced expression of minoxidil sulfotransferase in the hypothalamus uncovered by microarray analysis. Li, J.Y., Lescure, P.A., Misek, D.E., Lai, Y.M., Chai, B.X., Kuick, R., Thompson, R.C., Demo, R.M., Kurnit, D.M., Michailidis, G., Hanash, S.M., Gantz, I. J. Biol. Chem. (2002) [Pubmed]
  12. Localization of minoxidil sulfotransferase in rat liver and the outer root sheath of anagen pelage and vibrissa follicles. Dooley, T.P., Walker, C.J., Hirshey, S.J., Falany, C.N., Diani, A.R. J. Invest. Dermatol. (1991) [Pubmed]
  13. Phenol sulfotransferase activity in rat liver parenchymal cells cultured on collagen gels. Utesch, D., Oesch, F. Drug Metab. Dispos. (1992) [Pubmed]
  14. Characterization of the rates of testosterone metabolism to various products and of glutathione transferase and sulfotransferase activities in rat intestine and comparison to the corresponding hepatic and renal drug-metabolizing enzymes. Sohlenius-Sternbeck, A.K., Orzechowski, A. Chem. Biol. Interact. (2004) [Pubmed]
  15. Influence of culture system and medium enrichment on sulfotransferase and sulfatase expression in male rat hepatocyte cultures. Slaus, K., Coughtrie, M.W., Sharp, S., Vanhaecke, T., Vercruysse, A., Rogiers, V. Biochem. Pharmacol. (2001) [Pubmed]
  16. Enzyme- and sex-specific differences in the intralobular localizations and distributions of aryl sulfotransferase IV (tyrosine-ester sulfotransferase) and alcohol (hydroxysteroid) sulfotransferase a in rat liver. Chen, G., Baron, J., Duffel, M.W. Drug Metab. Dispos. (1995) [Pubmed]
  17. Sulfation is rate limiting in the futile cycling between estrone and estrone sulfate in enriched periportal and perivenous rat hepatocytes. Tan, E., Pang, K.S. Drug Metab. Dispos. (2001) [Pubmed]
  18. Effect of carcinogen dose fractionation, diet and source of F344 rat on the induction of colonic aberrant crypts by 2-amino-3-methylimidazo[4,5-f]quinoline. Xu, M., Chen, R., Dashwood, R.H. Carcinogenesis (1999) [Pubmed]
  19. Rat phenol-preferring sulfotransferase genes (Stp and Stp2): localization to mouse chromosomes 7 and 17. Khan, A.S., Taylor, B.R., Filie, J.D., Ringer, D.P., Kozak, C.A. Genomics (1995) [Pubmed]
  20. A single mutation converts the nucleotide specificity of phenol sulfotransferase from PAP to AMP. Hsiao, Y.S., Yang, Y.S. Biochemistry (2002) [Pubmed]
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