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Gene Review

Crybb2  -  crystallin, beta B2

Rattus norvegicus

Synonyms: Beta-B2 crystallin, Beta-crystallin B2, Beta-crystallin Bp
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Disease relevance of Crybb2


High impact information on Crybb2

  • However, recent data has shown GH receptor/binding protein (GHR/BP) to be present in rat fetal tissues as early as fetal stage E12 [3].
  • Third, GHR/BP mRNA was also found in regions remote from IGF-I mRNA, including the nerve ganglia and inner olfactory bulb [3].
  • The primary objective of the present experiment was to assess whether prior, chronic exposure to cocaine modulates expression of CRH-BP, and to compare expression of the BP with that of the peptide itself [4].
  • In other areas of the central nervous system, the BP seems positioned to serve as a transmitter/modulator at conventional synapses or as an autocrine or paracrine modulator of local CRF effects [5].
  • We conclude that disulfide-linked BP conjugates were readily cleavable by the amino acid cysteine in vitro, but in vivo cleavage of the disulfide-linked conjugates was not evident when the proteins were implanted adsorbed to mineral-based matrices [6].

Biological context of Crybb2

  • No significant changes in the ovarian concentration of GH-R/GH-BP transcripts were seen during the estrus cycle [7].
  • Hypophysectomy caused a decrease in GH-R/GH-BP gene expression in the ovary, an effect which could be partly reversed with a single injection of GH (2 mg/kg) [7].

Anatomical context of Crybb2


Associations of Crybb2 with chemical compounds

  • After gossypol treatment in the RPS, the synthesis of sperm-specific proteins (BP and X1) and core histones (H2A and H4) became drastically reduced [8].

Analytical, diagnostic and therapeutic context of Crybb2

  • We have used in situ hybridization to localize GHR/BP and IGF-I mRNAs in 16.5-, 18.5-, and 20.5-day-old rat fetuses [3].
  • The ontogeny of the GH-R/GH-BP mRNA expression was studied using Northern blot analysis and a solution hybridization RNase protection assay [7].


  1. Locally activated renin-angiotensin system associated with TGF-beta1 as a major factor for renal injury induced by chronic inhibition of nitric oxide synthase in rats. Kashiwagi, M., Shinozaki, M., Hirakata, H., Tamaki, K., Hirano, T., Tokumoto, M., Goto, H., Okuda, S., Fujishima, M. J. Am. Soc. Nephrol. (2000) [Pubmed]
  2. Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) Zucker rats. Timofeeva, E., Deshaies, Y., Picard, F., Richard, D. Am. J. Physiol. (1999) [Pubmed]
  3. Localization of growth hormone receptor/binding protein messenger ribonucleic acid (mRNA) during rat fetal development: relationship to insulin-like growth factor-I mRNA. Edmondson, S.R., Werther, G.A., Russell, A., LeRoith, D., Roberts, C.T., Beck, F. Endocrinology (1995) [Pubmed]
  4. Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis. Erb, S., Funk, D., Borkowski, S., Watson, S.J., Akil, H. Neuroscience (2004) [Pubmed]
  5. Ultrastructural localization of the corticotropin-releasing factor-binding protein in rat brain and pituitary. Peto, C.A., Arias, C., Vale, W.W., Sawchenko, P.E. J. Comp. Neurol. (1999) [Pubmed]
  6. A comparison of mineral affinity of bisphosphonate-protein conjugates constructed with disulfide and thioether linkages. Wright, J.E., Gittens, S.A., Bansal, G., Kitov, P.I., Sindrey, D., Kucharski, C., Uludağ, H. Biomaterials (2006) [Pubmed]
  7. Growth hormone-receptor messenger RNA in the rat ovary: regulation and localization. Carlsson, B., Nilsson, A., Isaksson, O.G., Billig, H. Mol. Cell. Endocrinol. (1993) [Pubmed]
  8. Biological activity in the repopulating rat spermatocyte after the withdrawal of gossypol treatment: II. The activity for the synthesis of cellular and nuclear basic proteins. Ye, B.K., Zhang, S.F., Teng, C.S. Contraception. (1989) [Pubmed]
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