The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Crhbp  -  corticotropin releasing hormone binding...

Rattus norvegicus

Synonyms: CRF-BP, CRF-binding protein, CRH-BP, Corticotropin-releasing factor-binding protein, Corticotropin-releasing hormone-binding protein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Crhbp


Psychiatry related information on Crhbp

  • Moreover, the magnitude of in vivo efficacy of the CRF-BP ligand inhibitor peptide in producing a mild increase in motor activity was dissociated from that of a postsynaptic CRF receptor agonist that exerted robust and long-lasting activity increases [3].
  • The enhanced CRH-BP expression in the MPOA and BLA in response to food deprivation was reversed by refeeding [2].

High impact information on Crhbp

  • Expression in the hypothalamus appears largely limited to the ventral premammillary and dorsomedial nuclei; only isolated CRF-BP-stained cells are apparent in neurosecretory cell groups [4].
  • Thus, CRF-BP could serve to modify the actions of CRF by intra- and intercellular mechanisms, in CRF-related pathways in the central nervous system and pituitary [4].
  • In recent studies to clone and characterize genes coding for the corticotropin-releasing factor-binding protein (CRF-BP), analysis of the tissue distribution of the CRF-BP gene indicated a high level of expression in the rat brain [4].
  • Results from both approaches converged to indicate that CRF-BP is expressed predominantly in the cerebral cortex, including all major archi-, paleo-, and neocortical fields [4].
  • Coordinate and divergent regulation of corticotropin-releasing factor (CRF) and CRF-binding protein expression in an immortalized amygdalar neuronal cell line [5].

Biological context of Crhbp

  • The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression [6].
  • These data also suggest that dexamethasone may decrease the biological availability of CRF in the amygdala by increasing the expression of CRF-BP, rather than by decreasing CRF expression [5].
  • These data also suggest that increased CRH-BP levels, in response to stress, may modulate the endocrine stress response by providing an additional feedback mechanism to maintain homeostasis of the hypothalamus-pituitary-adrenal axis [7].
  • To better study the regulation of CRF and CRF-BP, primary amygdalar cultures were immortalized by transfection with the SV 40 large T antigen [5].
  • To determine whether these changes in steady-state CRH-BP mRNA levels are caused by altered transcription or RNA stability, heteronuclear (hn) CRH-BP species were examined using ribonuclease protection assays [8].

Anatomical context of Crhbp


Associations of Crhbp with chemical compounds


Regulatory relationships of Crhbp


Other interactions of Crhbp

  • Few studies have examined the effects of acute stress on the regulation of amygdala CRF-BP with other CRF system genes [6].
  • Thus, CRF-BP ligand inhibitors appear to elicit generalized learning enhancement effects without mimicking the robust nonspecific behavioral actions of a CRF receptor agonist [3].
  • To define the relationship between CRF-BP-ir cells and endogenous ligands for CRF-BP, double immunohistochemistry was performed to examine possible sites within the hypothalamus where CRF- or urocortin 1-ir fibres innervate regions that contain CRF-BP-ir cell bodies [14].

Analytical, diagnostic and therapeutic context of Crhbp


  1. oCRF and CRF (6-33) depress food but not water intake in the obese Zucker rat. Bjenning, C.A., Rimvall, K. Int. J. Obes. Relat. Metab. Disord. (2000) [Pubmed]
  2. Corticotropin-releasing hormone-binding protein in brain and pituitary of food-deprived obese (fa/fa) Zucker rats. Timofeeva, E., Deshaies, Y., Picard, F., Richard, D. Am. J. Physiol. (1999) [Pubmed]
  3. Enhancement of performance in multiple learning tasks by corticotropin-releasing factor-binding protein ligand inhibitors. Heinrichs, S.C., Vale, E.A., Lapsansky, J., Behan, D.P., McClure, L.V., Ling, N., De Souza, E.B., Schulteis, G. Peptides (1997) [Pubmed]
  4. The central distribution of a corticotropin-releasing factor (CRF)-binding protein predicts multiple sites and modes of interaction with CRF. Potter, E., Behan, D.P., Linton, E.A., Lowry, P.J., Sawchenko, P.E., Vale, W.W. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  5. Coordinate and divergent regulation of corticotropin-releasing factor (CRF) and CRF-binding protein expression in an immortalized amygdalar neuronal cell line. Mulchahey, J.J., Regmi, A., Sheriff, S., Balasubramaniam, A., Kasckow, J.W. Endocrinology (1999) [Pubmed]
  6. The effects of acute stress on the regulation of central and basolateral amygdala CRF-binding protein gene expression. Herringa, R.J., Nanda, S.A., Hsu, D.T., Roseboom, P.H., Kalin, N.H. Brain Res. Mol. Brain Res. (2004) [Pubmed]
  7. Regulation of pituitary corticotropin-releasing hormone-binding protein messenger ribonucleic acid levels by restraint stress and adrenalectomy. McClennen, S.J., Cortright, D.N., Seasholtz, A.F. Endocrinology (1998) [Pubmed]
  8. Transcriptional regulation of corticotropin-releasing hormone-binding protein gene expression in astrocyte cultures. McClennen, S.J., Seasholtz, A.F. Endocrinology (1999) [Pubmed]
  9. Ultrastructural localization of the corticotropin-releasing factor-binding protein in rat brain and pituitary. Peto, C.A., Arias, C., Vale, W.W., Sawchenko, P.E. J. Comp. Neurol. (1999) [Pubmed]
  10. Effects of acute and repeated restraint stress on corticotropin-releasing hormone binding protein mRNA in rat amygdala and dorsal hippocampus. Lombardo, K.A., Herringa, R.J., Balachandran, J.S., Hsu, D.T., Bakshi, V.P., Roseboom, P.H., Kalin, N.H. Neurosci. Lett. (2001) [Pubmed]
  11. Amygdala-kindled seizures increase the expression of corticotropin-releasing factor (CRF) and CRF-binding protein in GABAergic interneurons of the dentate hilus. Smith, M.A., Weiss, S.R., Berry, R.L., Zhang, L.X., Clark, M., Massenburg, G., Post, R.M. Brain Res. (1997) [Pubmed]
  12. Effects of chronic cocaine exposure on corticotropin-releasing hormone binding protein in the central nucleus of the amygdala and bed nucleus of the stria terminalis. Erb, S., Funk, D., Borkowski, S., Watson, S.J., Akil, H. Neuroscience (2004) [Pubmed]
  13. Regulation of corticotropin-releasing factor-binding protein expression in cultured rat astrocytes. Maciejewski, D., Crowe, P.D., De Souza, E.B., Behan, D.P. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  14. Distribution of corticotropin-releasing factor binding protein-immunoreactivity in the rat hypothalamus: association with corticotropin-releasing factor-, urocortin 1- and vimentin-immunoreactive fibres. Henry, B.A., Lightman, S.L., Lowry, C.A. J. Neuroendocrinol. (2005) [Pubmed]
  15. Systemic adrenocorticotropic hormone administration down-regulates the expression of corticotropin-releasing hormone (CRH) and CRH-binding protein in infant rat hippocampus. Wang, W., Murphy, B., Dow, K.E., David Andrew, R., Fraser, D.D. Pediatr. Res. (2004) [Pubmed]
WikiGenes - Universities