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Gene Review

RAD54B  -  RAD54 homolog B (S. cerevisiae)

Homo sapiens

Synonyms: DNA repair and recombination protein RAD54B, RAD54 homolog B, RDH54
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Disease relevance of RAD54B


High impact information on RAD54B


Biological context of RAD54B

  • Hemostasis was achieved by 4 minutes in 64 subjects (63%) in the FSBP group and 40 subjects (40%) in the TSG group (P =.0018) [5].
  • The binding characteristics and quantitation of the recently reported fetal steroid binding protein (FSBP) cannot be determined on unpurified samples; an immunoassay was therefore desirable [6].
  • Percentage finger systolic blood pressure (%FSBP) in response to finger cooling is used to assess vascular components of the hand-arm vibration syndrome and the measurement method is under discussion for standardization [7].
  • METHOD: Thermal thresholds, vibrotactile thresholds, the finger skin temperature (FST) response to cold provocation and percentage finger systolic blood pressures (%FSBP) were measured by standardised procedures [8].
  • After partial purification of FSBP in these samples, the protein exhibited saturable binding kinetics, median binding 25 (interquartiles 23-34) and 19 (13-25) nmol DHT/l in Japanese and British women, respectively (P less than 0.05) [9].

Anatomical context of RAD54B

  • The expression of RAD54B was high in testis and spleen, which are active in meiotic and mitotic recombination [1].
  • Patients were randomized to FSBP application, which requires a 3-minute period of arterial clamping to enable the fibrin clot to adhere, or to TSG application, which requires pressure from gauze sponges, after completion of the femoral artery anastomosis [5].
  • Therefore, room temperature is expected to be controlled when assessing peripheral vascular components of the upper extremities using %FSBP response to finger cooling [7].

Associations of RAD54B with chemical compounds


Analytical, diagnostic and therapeutic context of RAD54B


  1. Mutations of a novel human RAD54 homologue, RAD54B, in primary cancer. Hiramoto, T., Nakanishi, T., Sumiyoshi, T., Fukuda, T., Matsuura, S., Tauchi, H., Komatsu, K., Shibasaki, Y., Inui, H., Watatani, M., Yasutomi, M., Sumii, K., Kajiyama, G., Kamada, N., Miyagawa, K., Kamiya, K. Oncogene (1999) [Pubmed]
  2. Interactions of foetal steroid binding protein with other binding proteins in human serum. Forbes, A., Wilkinson, M.L., Iqbal, M.J., Williams, R. Clin. Chim. Acta (1987) [Pubmed]
  3. A role for RAD54B in homologous recombination in human cells. Miyagawa, K., Tsuruga, T., Kinomura, A., Usui, K., Katsura, M., Tashiro, S., Mishima, H., Tanaka, K. EMBO J. (2002) [Pubmed]
  4. Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. Otterlei, M., Bruheim, P., Ahn, B., Bussen, W., Karmakar, P., Baynton, K., Bohr, V.A. J. Cell. Sci. (2006) [Pubmed]
  5. Prospective randomized multicenter trial of fibrin sealant versus thrombin-soaked gelatin sponge for suture- or needle-hole bleeding from polytetrafluoroethylene femoral artery grafts. Taylor, L.M., Mueller-Velten, G., Koslow, A., Hunter, G., Naslund, T., Kline, R. J. Vasc. Surg. (2003) [Pubmed]
  6. An enzyme-linked immunosorbent assay for fetal steroid binding protein of human serum. Iqbal, M.J., Forbes, A., Corbishley, T.P., Wilkinson, M.L., Williams, R. Steroids (1985) [Pubmed]
  7. Effect of room temperature on percentage finger systolic blood pressure response to finger cooling. Laskar, M.S., Ohmura, K., Inoue, M., Yokoyama, K., Inagaki, J., Takahashi, Y., Mahbub, M.H., Ohnari, H., Harada, N. European journal of applied physiology. (2005) [Pubmed]
  8. Normative data for vascular and neurological tests of the hand-arm vibration syndrome. Lindsell, C.J., Griffin, M.J. International archives of occupational and environmental health. (2002) [Pubmed]
  9. Foetal steroid binding protein in British and Japanese women. Iqbal, J.M., Forbes, A., Wilkinson, M.L., Moore, J.W., Williams, R., Bulbrook, R.D. Acta Endocrinol. (1987) [Pubmed]
  10. Homologous recombination is required for AAV-mediated gene targeting. Vasileva, A., Linden, R.M., Jessberger, R. Nucleic Acids Res. (2006) [Pubmed]
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