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Gene Review

LETMD1  -  LETM1 domain containing 1

Homo sapiens

Synonyms: 1110019O13Rik, Cervical cancer 1 proto-oncogene protein p40, Cervical cancer proto-oncogene 2 protein, HCCR-1, HCCR-2, ...
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Disease relevance of LETMD1


High impact information on LETMD1


Biological context of LETMD1


Anatomical context of LETMD1


Physical interactions of LETMD1


Other interactions of LETMD1

  • The epitope regions of HCCR recognized by monoclonal antibody (BCS-1) were HFWTPK and QQTDFLDIYHAFR [2].

Analytical, diagnostic and therapeutic context of LETMD1


  1. Transgenic mouse model for breast cancer: induction of breast cancer in novel oncogene HCCR-2 transgenic mice. Ko, J., Shin, S.M., Oh, Y.M., Lee, Y.S., Ryoo, Z.Y., Lee, Y.H., Na, D.S., Kim, J.W. Oncogene (2004) [Pubmed]
  2. The HCCR oncoprotein as a biomarker for human breast cancer. Jung, S.S., Park, H.S., Lee, I.J., Namkoong, H., Shin, S.M., Cho, G.W., Ha, S.A., Park, Y.G., Lee, Y.S., Ko, J., Kim, J.W. Clin. Cancer Res. (2005) [Pubmed]
  3. HCCR-1-interacting molecule "deleted in polyposis 1" plays a tumor-suppressor role in colon carcinogenesis. Shin, S.M., Chung, Y.J., Oh, S.T., Jeon, H.M., Hwang, L.J., Namkoong, H., Kim, H.K., Cho, G.W., Hur, S.Y., Kim, T.E., Lee, Y.S., Park, Y.G., Ko, J., Kim, J.W. Gastroenterology (2006) [Pubmed]
  4. The human cervical cancer oncogene protein is a biomarker for human hepatocellular carcinoma. Yoon, S.K., Lim, N.K., Ha, S.A., Park, Y.G., Choi, J.Y., Chung, K.W., Sun, H.S., Choi, M.J., Chung, J., Wands, J.R., Kim, J.W. Cancer Res. (2004) [Pubmed]
  5. The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression. Cho, G.W., Shin, S.M., Namkoong, H., Kim, H.K., Ha, S.A., Hur, S.Y., Kim, T.E., Chai, Y.G., Kim, J.W. Gene (2006) [Pubmed]
  6. Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in p53 stabilization. Ko, J., Lee, Y.H., Hwang, S.Y., Lee, Y.S., Shin, S.M., Hwang, J.H., Kim, J., Kim, Y.W., Jang, S.W., Ryoo, Z.Y., Kim, I.K., Namkoong, S.E., Kim, J.W. Oncogene (2003) [Pubmed]
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