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Gene Review

RAB11FIP1  -  RAB11 family interacting protein 1 (class I)

Homo sapiens

Synonyms: FLJ22524, FLJ22622, NOEL1A, RCP, Rab-coupling protein, ...
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Disease relevance of RAB11FIP1

  • Furthermore, significantly higher (P < 0.05) levels of RCP transcripts were detected during the peri-implantation phase in women with unexplained infertility (n=3) than in fertile women (n=3) [1].
  • Sp1/retinoblastoma control protein (RCP) DNA binding increased within 30 min and peaked at 2-4 h after IR (450-600 cGy) in confluent radioresistant human malignant melanoma (U1-Mel) cells [2].
  • These findings suggest that measurement of circulatory RCP and the immunohistochemical staining pattern of RCP in biopsy specimens could be exploited as an additional marker in diagnosis/prognosis of breast cancer in women [3].
  • Because other vitamin carrier proteins (VCP) have been shown to be overexpressed in patients with malignant disease, we evaluated serum RCP levels in patients with adenocarcinoma of the breast [4].
  • The pregnancies of two patients with mild intrahepatic cholestasis of pregnancy (RCP) were followed with detailed analyses of bile acids in urine [5].

High impact information on RAB11FIP1


Chemical compound and disease context of RAB11FIP1

  • Using moxestrol, an analogue of estrogen and transient transfection of deletion and mutation containing RCP promoter/reporter constructs in chicken hepatoma (LMH2A) cells, we identified an estrogen response unit (ERU) composed of two consensus ERE 1/2 sites and one non-consensus ERE 1/2 site [9].
  • Totally asymptomatic controls were characterized by a lack of anterior open bite, small symmetric RCP-ICP slides (greater than 0 less than 1 mm), and bilateral occlusal contact in RCP [10].

Biological context of RAB11FIP1


Anatomical context of RAB11FIP1


Associations of RAB11FIP1 with chemical compounds

  • In situ hybridization studies using digoxigenin-labeled DD2 revealed significantly higher (P < 0.05) localization of endometrial RCP transcripts in the proliferative phase than in the peri-implantation phase in control animals [1].
  • In this study we present the comparative molecular analysis of bacterial communities of the aquatic plant Lemna minor from a contaminated site (RCP) and from a laboratory culture (EPA), as well as each of these with the addition of cadmium [17].
  • Finally, the P2S2-5-Ava-BBN[7-14]NH2 bombesin (BBN) analogue was synthesized, the PH2 groups converted to P(CH2OH)2 groups and subsequently labeled with 188Re to yield a 188Re-labeled bombesin analogue with a RCP of >/=90% [18].
  • Interestingly, RCP promoter is regulated by moxestrol in estrogen responsive human MCF-7 cells, but not in other cell lines such as NIH3T3 and HepG2 despite estrogen receptor-alpha (ER-alpha) co transfection [9].
  • RESULTS: In both the RCP and the Triclosan group, gingival health improved significantly between baseline and the following examinations [19].

Physical interactions of RAB11FIP1

  • The Rab11 family of interacting proteins (Rab11-FIP) is a recently identified protein family composed of, to date, six members that interact with Rab11 [16].
  • However, Rab11-FIP4 does not appear to interact directly with Rab coupling protein (RCP) [20].
  • To date, five such proteins have been described in humans, all of which interact with Rab11, and one (RCP) also interacts with Rab4 [21].

Regulatory relationships of RAB11FIP1


Other interactions of RAB11FIP1

  • The binding of Rab11-FIP1, Rab11-FIP2, and Rab11-FIP3 to Rab11a was dependent upon a conserved carboxyl-terminal amphipathic alpha-helix [22].
  • RCP is a homologue of Rip11 and therefore belongs to the recently described Rab11-FIP family [15].
  • Furthermore, our data indicate that the RCP-Rab11 complex regulates the sorting of transferrin receptors from the degradative to the recycling pathway [8].
  • RESULTS: We observed amplification of 8p12 (amplified at RAB11FIP1 and/or FGFR1) in 22.8%, 8q24 in 6.1%, 11q13 in 19.6%, 12p13 in 4.1%, 17q12 in 9.9%, 20q13Z (amplified at ZNF217 only) in 9.9%, and 20q13Co (co-amplification of two or three 20q13 loci) in 8.5% of cases [23].
  • We have recently identified Rab11-FIP4 as the sixth member of the Rab11-FIP family of Rab11 interacting proteins [20].

Analytical, diagnostic and therapeutic context of RAB11FIP1


  1. Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium. Patil, V.S., Sachdeva, G., Modi, D.N., Katkam, R.R., Manjramkar, D.D., Hinduja, I., Puri, C.P. J. Mol. Endocrinol. (2005) [Pubmed]
  2. Coordinate modulation of Sp1, NF-kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation. Yang, C.R., Wilson-Van Patten, C., Planchon, S.M., Wuerzberger-Davis, S.M., Davis, T.W., Cuthill, S., Miyamoto, S., Boothman, D.A. FASEB J. (2000) [Pubmed]
  3. Riboflavin carrier protein: a serum and tissue marker for breast carcinoma. Karande, A.A., Sridhar, L., Gopinath, K.S., Adiga, P.R. Int. J. Cancer (2001) [Pubmed]
  4. Elevation of serum riboflavin carrier protein in breast cancer. Rao, P.N., Levine, E., Myers, M.O., Prakash, V., Watson, J., Stolier, A., Kopicko, J.J., Kissinger, P., Raj, S.G., Raj, M.H. Cancer Epidemiol. Biomarkers Prev. (1999) [Pubmed]
  5. Urinary bile acids during development of recurrent cholestasis of pregnancy. Thomassen, P.A. Eur. J. Clin. Invest. (1979) [Pubmed]
  6. Diminished support for linkage between manic depressive illness and X-chromosome markers in three Israeli pedigrees. Baron, M., Freimer, N.F., Risch, N., Lerer, B., Alexander, J.R., Straub, R.E., Asokan, S., Das, K., Peterson, A., Amos, J. Nat. Genet. (1993) [Pubmed]
  7. Apical recycling systems regulate directional budding of respiratory syncytial virus from polarized epithelial cells. Brock, S.C., Goldenring, J.R., Crowe, J.E. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. The RCP-Rab11 complex regulates endocytic protein sorting. Peden, A.A., Schonteich, E., Chun, J., Junutula, J.R., Scheller, R.H., Prekeris, R. Mol. Biol. Cell (2004) [Pubmed]
  9. Estrogen regulation of chicken riboflavin carrier protein gene is mediated by ERE half sites without direct binding of estrogen receptor. Bahadur, U., Ganjam, G.K., Vasudevan, N., Kondaiah, P. Mol. Cell. Endocrinol. (2005) [Pubmed]
  10. Association of occlusal variables among refined TM patient diagnostic groups. Seligman, D.A., Pullinger, A.G. Journal of craniomandibular disorders : facial & oral pain. (1989) [Pubmed]
  11. Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment. Damiani, M.T., Pavarotti, M., Leiva, N., Lindsay, A.J., McCaffrey, M.W., Colombo, M.I. Traffic (2004) [Pubmed]
  12. Molecular dissection of Rab11 binding from coiled-coil formation in the Rab11-FIP2 C-terminal domain. Wei, J., Fain, S., Harrison, C., Feig, L.A., Baleja, J.D. Biochemistry (2006) [Pubmed]
  13. The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system. Jin, M., Goldenring, J.R. Biochim. Biophys. Acta (2006) [Pubmed]
  14. A common set of nuclear factors bind to promoter elements regulated by the retinoblastoma protein. Udvadia, A.J., Rogers, K.T., Horowitz, J.M. Cell Growth Differ. (1992) [Pubmed]
  15. Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. Lindsay, A.J., Hendrick, A.G., Cantalupo, G., Senic-Matuglia, F., Goud, B., Bucci, C., McCaffrey, M.W. J. Biol. Chem. (2002) [Pubmed]
  16. The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane. Lindsay, A.J., McCaffrey, M.W. J. Cell. Sci. (2004) [Pubmed]
  17. Shifts in rhizoplane communities of aquatic plants after cadmium exposure. Stout, L.M., Nüsslein, K. Appl. Environ. Microbiol. (2005) [Pubmed]
  18. Synthesis, characterization, and labeling with 99mTc/188Re of peptide conjugates containing a dithia-bisphosphine chelating agent. Gali, H., Hoffman, T.J., Sieckman, G.L., Owen, N.K., Katti, K.V., Volkert, W.A. Bioconjug. Chem. (2001) [Pubmed]
  19. The effect of a SCN-/H2O2 toothpaste compared to a commercially available triclosan-containing toothpaste on oral hygiene and gingival health -- a 6-month home-use study. Rosin, M., Kramer, A., Bradtke, D., Richter, G., Kocher, T. Journal of clinical periodontology. (2002) [Pubmed]
  20. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells. Wallace, D.M., Lindsay, A.J., Hendrick, A.G., McCaffrey, M.W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  21. The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. Wallace, D.M., Lindsay, A.J., Hendrick, A.G., McCaffrey, M.W. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  22. Identification and characterization of a family of Rab11-interacting proteins. Hales, C.M., Griner, R., Hobdy-Henderson, K.C., Dorn, M.C., Hardy, D., Kumar, R., Navarre, J., Chan, E.K., Lapierre, L.A., Goldenring, J.R. J. Biol. Chem. (2001) [Pubmed]
  23. Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers. Letessier, A., Sircoulomb, F., Ginestier, C., Cervera, N., Monville, F., Gelsi-Boyer, V., Esterni, B., Geneix, J., Finetti, P., Zemmour, C., Viens, P., Charafe-Jauffret, E., Jacquemier, J., Birnbaum, D., Chaffanet, M. BMC Cancer (2006) [Pubmed]
  24. Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. Lindsay, A.J., McCaffrey, M.W. FEBS Lett. (2004) [Pubmed]
  25. Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. Chen, E.Y., Zollo, M., Mazzarella, R., Ciccodicola, A., Chen, C.N., Zuo, L., Heiner, C., Burough, F., Repetto, M., Schlessinger, D., D'Urso, M. Hum. Mol. Genet. (1996) [Pubmed]
  26. Recognition, cointernalization, and recycling of an avian riboflavin carrier protein in human placental trophoblasts. Mason, C.W., D'Souza, V.M., Bareford, L.M., Phelps, M.A., Ray, A., Swaan, P.W. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
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