Gene Review:
RAB4A - RAB4A, member RAS oncogene family
Homo sapiens
Synonyms:
HRES-1, HRES-1/RAB4, HRES1, RAB4, Ras-related protein Rab-4A
- Rab4 GTP/GDP modulates amiloride-sensitive sodium channel (ENaC) function in colonic epithelia. Saxena, S.K., Singh, M., Shibata, H., Kaur, S., George, C. Biochem. Biophys. Res. Commun. (2006)
- Endocytic pathway alterations in human hippocampus after global ischemia and the influence of APOE genotype. McColl, B.W., Graham, D.I., Weir, C.J., White, F., Horsburgh, K. Am. J. Pathol. (2003)
- Post-translational processing and membrane association of the two early endosome-associated rab GTP-binding proteins (rab4 and rab5). Li, G., Stahl, P.D. Arch. Biochem. Biophys. (1993)
- Regulation of CD4 Expression via Recycling by HRES-1/RAB4 Controls Susceptibility to HIV Infection. Nagy, G., Ward, J., Mosser, D.D., Koncz, A., Gergely, P., Stancato, C., Qian, Y., Fernandez, D., Niland, B., Grossman, C.E., Telarico, T., Banki, K., Perl, A. J. Biol. Chem. (2006)
- The small GTP-binding protein rab4 controls an early sorting event on the endocytic pathway. van der Sluijs, P., Hull, M., Webster, P., Mâle, P., Goud, B., Mellman, I. Cell (1992)
- Phosphorylation of two small GTP-binding proteins of the Rab family by p34cdc2. Bailly, E., McCaffrey, M., Touchot, N., Zahraoui, A., Goud, B., Bornens, M. Nature (1991)
- Endocytic recycling pathways: emerging regulators of cell migration. Jones, M.C., Caswell, P.T., Norman, J.C. Curr. Opin. Cell Biol. (2006)
- The RCP-Rab11 complex regulates endocytic protein sorting. Peden, A.A., Schonteich, E., Chun, J., Junutula, J.R., Scheller, R.H., Prekeris, R. Mol. Biol. Cell (2004)
- CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. Cormont, M., Metón, I., Mari, M., Monzo, P., Keslair, F., Gaskin, C., McGraw, T.E., Le Marchand-Brustel, Y. Traffic (2003)
- High resolution crystal structures of human Rab4a in its active and inactive conformations. Huber, S.K., Scheidig, A.J. FEBS Lett. (2005)
- Rab4GTPase modulates CFTR function by impairing channel expression at plasma membrane. Saxena, S.K., Kaur, S., George, C. Biochem. Biophys. Res. Commun. (2006)
- Rabaptin-5alpha/rabaptin-4 serves as a linker between rab4 and gamma(1)-adaptin in membrane recycling from endosomes. Deneka, M., Neeft, M., Popa, I., van Oort, M., Sprong, H., Oorschot, V., Klumperman, J., Schu, P., van der Sluijs, P. EMBO J. (2003)
- Reversible phosphorylation--dephosphorylation determines the localization of rab4 during the cell cycle. van der Sluijs, P., Hull, M., Huber, L.A., Mâle, P., Goud, B., Mellman, I. EMBO J. (1992)
- Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling. Choudhury, A., Sharma, D.K., Marks, D.L., Pagano, R.E. Mol. Biol. Cell (2004)
- The Rab4A Effector Protein Rabip4 Is Involved in Migration of NIH 3T3 Fibroblasts. Vukmirica, J., Monzo, P., Le Marchand-Brustel, Y., Cormont, M. J. Biol. Chem. (2006)
- Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4. Mari, M., Macia, E., Le Marchand-Brustel, Y., Cormont, M. J. Biol. Chem. (2001)
- Neisseria gonorrhoeae porin modulates phagosome maturation. Mosleh, I.M., Huber, L.A., Steinlein, P., Pasquali, C., Günther, D., Meyer, T.F. J. Biol. Chem. (1998)
- Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. de Renzis, S., Sönnichsen, B., Zerial, M. Nat. Cell Biol. (2002)
- Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5. Vitale, G., Rybin, V., Christoforidis, S., Thornqvist, P., McCaffrey, M., Stenmark, H., Zerial, M. EMBO J. (1998)
- Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. Lindsay, A.J., McCaffrey, M.W. FEBS Lett. (2004)
- Accumulation of rab4GTP in the cytoplasm and association with the peptidyl-prolyl isomerase pin1 during mitosis. Gerez, L., Mohrmann, K., van Raak, M., Jongeneelen, M., Zhou, X.Z., Lu, K.P., van Der Sluijs, P. Mol. Biol. Cell (2000)
- General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications. Shisheva, A., Chinni, S.R., DeMarco, C. Biochemistry (1999)
- Rab15 differentially regulates early endocytic trafficking. Zuk, P.A., Elferink, L.A. J. Biol. Chem. (2000)
- Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein. Lindsay, A.J., Hendrick, A.G., Cantalupo, G., Senic-Matuglia, F., Goud, B., Bucci, C., McCaffrey, M.W. J. Biol. Chem. (2002)
- Differential expression of low Mr GTP-binding proteins in human megakaryoblastic leukemia cell line, MEG-01, and their possible involvement in the differentiation process. Nagata, K., Okano, Y., Nozawa, Y. Thromb. Haemost. (1997)
- Rab4 and Rab7 define distinct nonoverlapping endosomal compartments. Bottger, G., Nagelkerken, B., van der Sluijs, P. J. Biol. Chem. (1996)
- Conformationally variable Rab protein surface regions mapped by limited proteolysis and homology modelling. Nikolova, L., Soman, K., Nichols, J.C., Daniel, D.S., Dickey, B.F., Hoffenberg, S. Biochem. J. (1998)
- Rab4 associates with the actin terminal web in developing rat pancreatic acinar cells. Valentijn, J.A., LaCivita, D.Q., Gumkowski, F.D., Jamieson, J.D. Eur. J. Cell Biol. (1997)