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Gene Review

IFT172  -  intraflagellar transport 172

Homo sapiens

Synonyms: Intraflagellar transport protein 172 homolog, KIAA1179, NPHP17, SLB, SRTD10, ...
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Disease relevance of IFT172

  • STUDY OBJECTIVES: Presently, surgical (open or thoracoscopic) lung biopsy (SLB) is the gold standard for the diagnosis of new-onset idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases (ILDs) [1].
  • T cells from a patient with malignant melanoma were infected with HTLV I by co-culture with a HTLV I-producing T cell line, SLB I [2].
  • Mean maximal binding (Bmax) of the alpha2-adrenoceptor antagonist [3H]rauwolscine to platelet membranes was significantly reduced (P < 0.001) after exposure to chronic hypoxia [SLB: 172.6 (48.5) fmol x mg(-1) protein versus SLA: 136.8 (56.1) fmol x mg(-1) protein] without change in the dissociation constant (K(D)) [3].
  • Forty-eight percent of SLB sera contained aAbs directed against the ribosomal proteins of the 60 S subunit compared to 9% for RA, 5% for blood donors and 0% for thyroiditis [4].

High impact information on IFT172


Biological context of IFT172


Anatomical context of IFT172

  • Diurnal variations in the rate of DNA synthesis by circulating lymphocytes of healthy men were measured in vitro by SLB at 2-hr intervals for 24 hr [6].
  • In each species, an apparent rhythmic feeding motor program (FMP) was observed by intracellular recording from both SLB neurons and other neurons in isolated preparations of the buccal ganglia [7].
  • The data were consistent with Na+ and Cl- ions initially remaining inside the cell and a cell membrane Lp of 10(-3) cm sec-1 osm-1, which is close to the values determined by Spring and co-workers (K.R. Spring, A. Hope & B.E. Persson, 1981. In: Water Transport Across Epithelia. Alfred Benzon Symposium 15. pp. 190-200. Munskgaard, Copenhagen) [10].
  • The system was designated SLB and its product (antigen SLB-A1) was demonstrated in all lymphocytes from the lymph nodes, thymus and peripheral blood, but not in the erythrocytes [11].


  1. The accuracy of the clinical diagnosis of new-onset idiopathic pulmonary fibrosis and other interstitial lung disease: A prospective study. Raghu, G., Mageto, Y.N., Lockhart, D., Schmidt, R.A., Wood, D.E., Godwin, J.D. Chest (1999) [Pubmed]
  2. Functionally different HTLV I-infected T cell lines with the same phenotype derived from a patient with melanoma. Sivanandham, M., Mukherji, B. Immunol. Lett. (1989) [Pubmed]
  3. Effects of prolonged high-altitude exposure on peripheral adrenergic receptors in young healthy volunteers. Fischetti, F., Fabris, B., Zaccaria, M., Biagi, A., Calci, M., Candido, R., Bortoletto, M., Caretta, R. European journal of applied physiology. (2000) [Pubmed]
  4. Autoantibodies directed against ribosomal proteins in systemic lupus erythematosus and rheumatoid arthritis: a comparative study. Desbos, A., Gonzalo, P., Monier, J.C., Tebib, J., Reboud, J.P., Perrier, H., Bienvenu, J., Fabien, N. Autoimmunity (2002) [Pubmed]
  5. Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors. Howard, P.W., Maurer, R.A. J. Biol. Chem. (2000) [Pubmed]
  6. Standardization of tissue culture conditions for spontaneous thymidine-2-14C incorporation by unstimulated normal human peripheral lymphocytes: circadian rhythm of DNA synthesis. Carter, J.B., Barr, G.D., Levin, A.S., Byers, V.S., Ponce, B., Fudenberg, H.H., German, D.F. J. Allergy Clin. Immunol. (1975) [Pubmed]
  7. Evidence for homologous peptidergic neurons in the buccal ganglia of diverse nudibranch mollusks. Watson, W.H., Willows, A.O. J. Neurobiol. (1992) [Pubmed]
  8. Complete amino acid sequence of Scytalidium lignicolum acid protease B. Maita, T., Nagata, S., Matsuda, G., Maruta, S., Oda, K., Murao, S., Tsuru, D. J. Biochem. (1984) [Pubmed]
  9. The presence of blood group and lymphocyte antigens on porcine granulocytes. Klaudy, J., Hruban, V., Hradecký, J., Pazdera, J., Pech, V. Animal blood groups and biochemical genetics. (1981) [Pubmed]
  10. Relations between intracellular ion activities and extracellular osmolarity in Necturus gallbladder epithelium. Zeuthen, T. J. Membr. Biol. (1982) [Pubmed]
  11. SLB, a new alloantigenic system of the pig. Hruban, V., Hradecký, J., Pazdera, J., Simon, M., Veselský, L. J. Immunogenet. (1978) [Pubmed]
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