Gene Review:
LHX4 - LIM homeobox 4
Homo sapiens
Synonyms:
Gsh4, LIM homeobox protein 4, LIM/homeobox protein Lhx4
- Aberrant expression of the LHX4 LIM-homeobox gene caused by t(1;14)(q25;q32) in chronic myelogenous leukemia in biphenotypic blast crisis. Yamaguchi, M., Yamamoto, K., Miura, O. Genes Chromosomes Cancer (2003)
- Hormonal, pituitary magnetic resonance, LHX4 and HESX1 evaluation in patients with hypopituitarism and ectopic posterior pituitary lobe. Melo, M.E., Marui, S., Carvalho, L.R., Arnhold, I.J., Leite, C.C., Mendon??a, B.B., Knoepfelmacher, M. Clin. Endocrinol. (Oxf) (2007)
- Exclusion of the lim homeodomain gene LHX4 as a candidate gene for pituitary dwarfism in German shepherd dogs. van Oost, B.A., Versteeg, S.A., Imholz, S., Kooistra, H.S. Mol. Cell. Endocrinol. (2002)
- A novel dysfunctional LHX4 mutation with high phenotypical variability in patients with hypopituitarism. Castinetti, F., Saveanu, A., Reynaud, R., Quentien, M.H., Buffin, A., Brauner, R., Kaffel, N., Albarel, F., Guedj, A.M., El Kholy, M., Amin, M., Enjalbert, A., Barlier, A., Brue, T. J. Clin. Endocrinol. Metab. (2008)
- Pathophysiology of syndromic combined pituitary hormone deficiency due to a LHX3 defect in light of LHX3 and LHX4 expression during early human development. Sobrier, M.L., Attié-Bitach, T., Netchine, I., Encha-Razavi, F., Vekemans, M., Amselem, S. Gene Expr. Patterns (2004)
- Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4. Machinis, K., Pantel, J., Netchine, I., Léger, J., Camand, O.J., Sobrier, M.L., Dastot-Le Moal, F., Duquesnoy, P., Abitbol, M., Czernichow, P., Amselem, S. Am. J. Hum. Genet. (2001)
- Lhx4 and Prop1 are required for cell survival and expansion of the pituitary primordia. Raetzman, L.T., Ward, R., Camper, S.A. Development (2002)
- Identification of a conserved protein that interacts with specific LIM homeodomain transcription factors. Howard, P.W., Maurer, R.A. J. Biol. Chem. (2000)
- Functional relationship between LHX4 and POU1F1 in light of the LHX4 mutation identified in patients with pituitary defects. Machinis, K., Amselem, S. J. Clin. Endocrinol. Metab. (2005)
- cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4. Liu, Y., Fan, M., Yu, S., Zhou, Y., Wang, J., Yuan, J., Qiang, B. Brain Res. (2002)
- Adrenocorticotrope deficiency with clinical evidence for late onset in combined pituitary hormone deficiency caused by a homozygous 301-302delAG mutation of the PROP1 gene. Lamesch, C., Neumann, S., Pfäffle, R., Kiess, W., Paschke, R. Pituitary (2002)