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Gene Review

TSPO  -  translocator protein (18kDa)

Bos taurus

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Disease relevance of BZRP

  • Bovine herpesvirus type 1 (BoHV-1) is the causative agent of respiratory and genital tract infections such as infectious rhinotracheitis (IBR), infectious pustular vulvovaginitis (IPV, balanoposthitis (IBP), and abortion [1].
  • BHV1 subtypes 1 and 2a are mainly associated with the respiratory form of the disease (IBR), subtype 2b with IPV/IBP, and subtype 3 with encephalitis [2].

High impact information on BZRP


Anatomical context of BZRP

  • Consistently, the major secretion of chromaffin cells, epinephrine dose-dependently stimulated StAR expression with no effect on PBR mRNA [5].
  • The density of bovine peripheral-type benzodiazepine receptors (PBR) in four tissues was highest in adrenal cortex [6].
  • The adrenal cortex PBR cofractionated with a mitochondrial membrane marker enzyme and could be solubilized with intact ligand binding properties using digitonin [6].
  • We also examined the possible involvement of peripheral-type benzodiazepine receptor (PBR) in hemin/protoporphyrin IX-induced differentiation of K562 cells by the use of its ligands [7].
  • Previous studies have indicated that peripheral benzodiazepine receptor (PBR) ligands inhibit aldosterone secretion in isolated adrenal zona glomerulosa cells although positive responses have been demonstrated in other steroidogenic tissues [8].

Associations of BZRP with chemical compounds

  • High affinity binding of isoquinolines, such as PK 11195, is a conserved feature of peripheral-type benzodiazepine receptors (PBR) across species [4].
  • The exchange of Met-154 for valine in the bovine PBR introduced a binding site for Ro5-4864, which is absent in the native PBR [9].
  • By Northern analysis and the quantitative technique of TaqMan PCR we investigated whether chromaffin cells influence the regulation of StAR and the peripheral benzodiazepine receptor (PBR), both required for the rate-limiting step, the delivery of cholesterol to the inner mitochondrial membrane [5].
  • Bovine pineal PBR were further characterized with compounds structurally related to either Ro 5-4864 or PK 11195.(ABSTRACT TRUNCATED AT 250 WORDS)[10]
  • In conclusion, adrenomedullary secretory products are not necessary for the maintenance of PBR expression but facilitate steroid biosynthesis by increasing StAR mRNA expression and therefore can account for an ACTH-independent regulation of the rate-limiting step in steroidogenesis [5].


  1. Pro and contra IBR-eradication. Ackermann, M., Engels, M. Vet. Microbiol. (2006) [Pubmed]
  2. Risk of infection with bovine herpes virus 1 (BHV1): a review. Wentink, G.H., van Oirschot, J.T., Verhoeff, J. The Veterinary quarterly. (1993) [Pubmed]
  3. Identification of des-(Gly-Ile)-endozepine as an effector of corticotropin-dependent adrenal steroidogenesis: stimulation of cholesterol delivery is mediated by the peripheral benzodiazepine receptor. Besman, M.J., Yanagibashi, K., Lee, T.D., Kawamura, M., Hall, P.F., Shively, J.E. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  4. Cloning and expression of a pharmacologically unique bovine peripheral-type benzodiazepine receptor isoquinoline binding protein. Parola, A.L., Stump, D.G., Pepperl, D.J., Krueger, K.E., Regan, J.W., Laird, H.E. J. Biol. Chem. (1991) [Pubmed]
  5. Expression of adrenocortical steroidogenic acute regulatory (StAR) protein is influenced by chromaffin cells. Haidan, A., Bornstein, S.R., Liu, Z., Walsh, L.P., Stocco, D.M., Ehrhart-Bornstein, M. Mol. Cell. Endocrinol. (2000) [Pubmed]
  6. The bovine peripheral-type benzodiazepine receptor: a receptor with low affinity for benzodiazepines. Parola, A.L., Laird, H.E. Life Sci. (1991) [Pubmed]
  7. Hemin-induced erythroid differentiation of human myeloleukemia K562 cell line and its modification by bioresponse modifiers. Nakajima, O., Iwasaki, S., Hashimoto, Y. Cell. Mol. Biol. (Noisy-le-grand) (1997) [Pubmed]
  8. Stimulation of aldosterone secretion by benzodiazepines in bovine adrenocortical cells. Kenyon, C.J., Thomson, I., Fraser, R. Fundamental & clinical pharmacology. (1999) [Pubmed]
  9. Site-directed mutagenesis of the peripheral benzodiazepine receptor: identification of amino acids implicated in the binding site of Ro5-4864. Farges, R., Joseph-Liauzun, E., Shire, D., Caput, D., Le Fur, G., Ferrara, P. Mol. Pharmacol. (1994) [Pubmed]
  10. Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site. Basile, A.S., Klein, D.C., Skolnick, P. Brain Res. (1986) [Pubmed]
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