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Gene Review

HPRT1  -  hypoxanthine phosphoribosyltransferase 1

Bos taurus

Synonyms: HGPRT, HPRT
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High impact information on HPRT1


Biological context of HPRT1


Anatomical context of HPRT1


Associations of HPRT1 with chemical compounds

  • A significant increase in hprt mutation frequency was detected in alveolar epithelial cells obtained from rats exposed to ENU or alpha-quartz; the latter observation is the first demonstration that crystalline silica exposure is mutagenic in vivo [8].
  • Sensitivity of ticks to allopurinol, an inhibitor of hypoxanthine-guanine-phosphoribosyltransferase, supports the importance of purine salvage in this tick and the potential role of nucleotidase in this pathway [10].
  • These results indicate that HPRT activity of bovine preimplantation embryos can be microassayed using radiolabeled hypoxanthine, and this assay could provide an alternative method for embryo sexing [7].
  • In summary, these studies show that rat alveolar epithelial cells isolated by pronase digestion and Nycodenz separation techniques and cultured in a defined media can be used in a clonal selection assay for mutation in the hprt gene [8].
  • The rat alveolar epithelial cell cultures were exposed in vitro to the mutagens ethylnitrosourea (ENU) and H2O2, and mutation in the hprt gene was selected for by culture in the presence of the toxic purine analog, 6-thioguanine (6TG) [8].

Analytical, diagnostic and therapeutic context of HPRT1


  1. Fibroblast growth factor-dependent metabolism of hypoxanthine via the salvage pathway for purine synthesis in porcine aortic endothelial cells. Hirai, S., Hayashi, Y., Koizumi, T., Nakanishi, N., Fukui, T., Ichikawa, A. Biochem. Pharmacol. (1993) [Pubmed]
  2. Sex-chromosome linked gene expression in in-vitro produced bovine embryos. Peippo, J., Farazmand, A., Kurkilahti, M., Markkula, M., Basrur, P.K., King, W.A. Mol. Hum. Reprod. (2002) [Pubmed]
  3. Differential expression of two genes located on the X chromosome between male and female in vitro-produced bovine embryos at the blastocyst stage. Gutiérrez-Adán, A., Oter, M., Martínez-Madrid, B., Pintado, B., De La Fuente, J. Mol. Reprod. Dev. (2000) [Pubmed]
  4. Use of cryopreserved peripheral mononuclear blood cells in biomonitoring. Risom, L., Knudsen, L.E. Mutat. Res. (1999) [Pubmed]
  5. Clarifications on breakpoints in HSAX and BTAX by comparative mapping of F9, HPRT, and XIST in cattle. Goldammer, T., Amaral, M.E., Brunner, R.M., Owens, E., Kata, S.R., Schwerin, M., Womack, J.E. Cytogenet. Genome Res. (2003) [Pubmed]
  6. Characterization of hybrids between bovine (MDBK) and mouse (L-cell) cell lines. Chinchar, V.G., Floyd, A.D., Chinchar, G.D., Taylor, M.W. Biochem. Genet. (1979) [Pubmed]
  7. Hypoxanthine phosphoribosyltransferase activity in bovine embryos during the early embryonic development. Kita, M., Imai, H. Theriogenology (1993) [Pubmed]
  8. Characterizing mutagenesis in the hprt gene of rat alveolar epithelial cells. Driscoll, K.E., Deyo, L.C., Howard, B.W., Poynter, J., Carter, J.M. Exp. Lung Res. (1995) [Pubmed]
  9. Deficiency of UMP synthase in dairy cattle: a model for hereditary orotic aciduria. Harden, K.K., Robinson, J.L. J. Inherit. Metab. Dis. (1987) [Pubmed]
  10. Localisation and functional studies on the 5'-nucleotidase of the cattle tick Boophilus microplus. Liyou, N., Hamilton, S., Mckenna, R., Elvin, C., Willadsen, P. Exp. Appl. Acarol. (2000) [Pubmed]
  11. Studies of an unusually basic hypoxanthine-guanine phosphoribosyltransferase. Paulus, V.A., Ingalls, R.G., Vasquez, B., Bieber, A.L. J. Biol. Chem. (1980) [Pubmed]
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