The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Exypaque     N,N'-bis(2,3- dihydroxypropyl)-5-(2,3...

Synonyms: Nycodenz, Histodenz, Iohexolum, Omnipaque, iohexol, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Nycodenz

  • Standing the media before injection resulted in a highly significant reduction of air embolism, reducing the total mean duration of emboli from 1.32 (SD 0.60) s after immediate injection to 0.04 (0.05) s after ten minutes standing for iohexol 340 mg/mL (p < 0.001) [1].
  • Prolonged paraplegia after iohexol myelography [2].
  • Approximately 30 minutes after ischemia, functional CT images were collected with the use of a dynamic scanning protocol with bolus injections of nonionic contrast agent iohexol (1 mL/kg) [3].
  • Its effect on the intracellular location of poliovirus was studied by separating subcellular fractions in iso-osmotic Nycodenz gradients [4].
  • To detect both DNA-capsid and DNA-DNA cross-links, DNA is expelled from the T7 capsid and the products of expulsion are analyzed by use of Nycodenz buoyant density centrifugation, followed by either pulsed field gel electrophoresis or invariant field gel electrophoresis [5].

Psychiatry related information on Nycodenz


High impact information on Nycodenz

  • To establish the subcellular localization of the 3-oxoacyl-CoA thiolase precursor protein, cultured skin fibroblasts were fractionated on a continuous Nycodenz gradient [10].
  • Iohexol to monitor GFR [11].
  • The Pal1 polypeptide was highly enriched in the organellar pellet fraction prepared from wild-type cells by differential centrifugation and comigrated upon velocity sedimentation in a Nycodenz gradient with a known component of the peroxisomal matrix, e-oxoacyl-CoA thiolase [12].
  • Constitutive secretory vesicles carrying heparan sulfate proteoglycan (HSPG) were identified in isolated rat hepatocytes by pulse-chase experiments with [35S]sulfate and purified by velocity-controlled sucrose gradient centrifugation followed by equilibrium density centrifugation in Nycodenz [13].
  • Other constitutively secreted proteins (rat serum albumin, apolipoprotein E, and fibrinogen) could not be detected in purified HSPG-carrying vesicles, but banded in the denser fractions of the Nycodenz gradient [13].

Chemical compound and disease context of Nycodenz


Biological context of Nycodenz


Anatomical context of Nycodenz


Associations of Nycodenz with other chemical compounds


Gene context of Nycodenz


Analytical, diagnostic and therapeutic context of Nycodenz


  1. Microscopic air embolism during cerebral angiography and strategies for its avoidance. Markus, H., Loh, A., Israel, D., Buckenham, T., Clifton, A., Brown, M.M. Lancet (1993) [Pubmed]
  2. Prolonged paraplegia after iohexol myelography. Noda, K., Miyamoto, K., Beppu, H., Hirose, K., Tanabe, H. Lancet (1991) [Pubmed]
  3. YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats. Shimizu-Sasamata, M., Kano, T., Rogowska, J., Wolf, G.L., Moskowitz, M.A., Lo, E.H. Stroke (1998) [Pubmed]
  4. Effect of a capsid-stabilizing pyridazinamine, R 78206, on the eclipse and intracellular location of poliovirus. Ofori-Anyinam, O., Vrijsen, R., Kronenberger, P., Boeyé, A. J. Virol. (1993) [Pubmed]
  5. Conformation of DNA packaged in bacteriophage T7. Analysis by use of ultraviolet light-induced DNA-capsid cross-linking. Serwer, P., Hayes, S.J., Watson, R.H. J. Mol. Biol. (1992) [Pubmed]
  6. Effects of nonionic monomeric and dimeric contrast media on the twitching reaction of the rat. Importance of osmolality and electrolyte content. Bååth, L., Besjakov, J., Pettersson, G. Investigative radiology. (1994) [Pubmed]
  7. Transient global amnesia after cerebral angiography with iohexol. Juni, J., Morera, J., Láinez, J.M., Escudero, J., Ferrer, C., Sancho, J. Neuroradiology. (1992) [Pubmed]
  8. Intracranial iohexol-distribution following cervical myelography, postmyelographic registration of adverse effects, psychometric assessment and electroencephalographic recording. Olsen, N.K., Madsen, H.H., Eriksen, F.B., Svare, U., Zeeberg, I. Acta neurologica Scandinavica. (1990) [Pubmed]
  9. Central nervous system reactions to cervical myelography. Vestergaard, A., Dons, K., Eskesen, V., Kruse-Larsen, C., Lyon, B.B., Søborg, P.A., Jensen, N.O., Praestholm, J. Acta radiologica (Stockholm, Sweden : 1987) (1991) [Pubmed]
  10. Rhizomelic chondrodysplasia punctata. Deficiency of 3-oxoacyl-coenzyme A thiolase in peroxisomes and impaired processing of the enzyme. Heikoop, J.C., van Roermund, C.W., Just, W.W., Ofman, R., Schutgens, R.B., Heymans, H.S., Wanders, R.J., Tager, J.M. J. Clin. Invest. (1990) [Pubmed]
  11. Iohexol to monitor GFR. Brown, S. Lancet (1992) [Pubmed]
  12. The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae. Swartzman, E.E., Viswanathan, M.N., Thorner, J. J. Cell Biol. (1996) [Pubmed]
  13. ADP ribosylation factor and a 14-kD polypeptide are associated with heparan sulfate-carrying post-trans-Golgi network secretory vesicles in rat hepatocytes. Nickel, W., Huber, L.A., Kahn, R.A., Kipper, N., Barthel, A., Fasshauer, D., Söling, H.D. J. Cell Biol. (1994) [Pubmed]
  14. Potential interference of agents on radioiodide thyroid uptake in the euthyroid rat. Yu, M.D., Shaw, S.M. J. Nucl. Med. (2003) [Pubmed]
  15. Variable effects of radiological contrast media on thrombus growth in a rabbit jugular vein thrombosis model. Levi, M., Biemond, B.J., Sturk, A., Hoek, J., ten Cate, J.W. Thromb. Haemost. (1991) [Pubmed]
  16. Intraocular radiation blocking. Finger, P.T., Ho, T.K., Fastenberg, D.M., Hyman, R.A., Stroh, E.M., Packer, S., Perry, H.D. Invest. Ophthalmol. Vis. Sci. (1990) [Pubmed]
  17. A comparative study of contrast agents for endoscopic retrograde pancreatography. Barkin, J.S., Casal, G.L., Reiner, D.K., Goldberg, R.I., Phillips, R.S., Kaplan, S. Am. J. Gastroenterol. (1991) [Pubmed]
  18. Intrathecal toxicity of iohexol vs. metrizamide. Survey and current state. Haughton, V.M. Investigative radiology. (1985) [Pubmed]
  19. Intracoronary albunex. Its effects on left ventricular hemodynamics, function, and coronary sinus flow in humans. Ten Cate, F.J., Widimsky, P., Cornel, J.H., Waldstein, D.J., Serruys, P.W., Waaler, A. Circulation (1993) [Pubmed]
  20. Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. Gaspari, F., Perico, N., Ruggenenti, P., Mosconi, L., Amuchastegui, C.S., Guerini, E., Daina, E., Remuzzi, G. J. Am. Soc. Nephrol. (1995) [Pubmed]
  21. Effects of a new nonionic and a conventional ionic contrast agent on coronary sinus ionized calcium and left ventricular hemodynamics in dogs. Bourdillon, P.D., Bettmann, M.A., McCracken, S., Poole-Wilson, P.A., Grossman, W. J. Am. Coll. Cardiol. (1985) [Pubmed]
  22. Lipoprotein(a) serum concentrations and apolipoprotein(a) phenotypes in mild and moderate renal failure. Kronenberg, F., Kuen, E., Ritz, E., Junker, R., König, P., Kraatz, G., Lhotta, K., Mann, J.F., Müller, G.A., Neyer, U., Riegel, W., Reigler, P., Schwenger, V., Von Eckardstein, A. J. Am. Soc. Nephrol. (2000) [Pubmed]
  23. In vitro import of proteins into mitochondria of Trypanosoma brucei and Leishmania tarentolae. Hauser, R., Pypaert, M., Häusler, T., Horn, E.K., Schneider, A. J. Cell. Sci. (1996) [Pubmed]
  24. Quality control in the secretory pathway: retention of a misfolded viral membrane glycoprotein involves cycling between the ER, intermediate compartment, and Golgi apparatus. Hammond, C., Helenius, A. J. Cell Biol. (1994) [Pubmed]
  25. Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils. Levi-Schaffer, F., Lacy, P., Severs, N.J., Newman, T.M., North, J., Gomperts, B., Kay, A.B., Moqbel, R. Blood (1995) [Pubmed]
  26. Intracellular localization of interleukin-6 in eosinophils from atopic asthmatics and effects of interferon gamma. Lacy, P., Levi-Schaffer, F., Mahmudi-Azer, S., Bablitz, B., Hagen, S.C., Velazquez, J., Kay, A.B., Moqbel, R. Blood (1998) [Pubmed]
  27. Vascular exchange in the kidney. Regional characterization by multiple indicator tomography. Lumsden, C.J., Silverman, M., Zielinski, A., Potts, D.G., Shafik, I., Brody, A.S., Whiteside, C.I., Violante, M. Circ. Res. (1993) [Pubmed]
  28. Factors that modify the flow response to intracoronary injections. Emanuelsson, H., Holmberg, S., Selin, K., Wallin, J. Circulation (1985) [Pubmed]
  29. Phytanic acid alpha-oxidation. Differential subcellular localization in rat and human tissues and its inhibition by nycodenz. Singh, I., Pahan, K., Dhaunsi, G.S., Lazo, O., Ozand, P. J. Biol. Chem. (1993) [Pubmed]
  30. Peroxisomal localization of acyl-coenzyme A reductase (long chain alcohol forming) in guinea pig intestine mucosal cells. Burdett, K., Larkins, L.K., Das, A.K., Hajra, A.K. J. Biol. Chem. (1991) [Pubmed]
  31. Radiocontrast agents induce endothelin release in vivo and in vitro. Heyman, S.N., Clark, B.A., Kaiser, N., Spokes, K., Rosen, S., Brezis, M., Epstein, F.H. J. Am. Soc. Nephrol. (1992) [Pubmed]
  32. Preventing renal complications in type 2 diabetes: results of the diabetics exposed to telmisartan and enalapril trial. Barnett, A. J. Am. Soc. Nephrol. (2006) [Pubmed]
  33. Identification of interleukin-2 in human peripheral blood eosinophils. Levi-Schaffer, F., Barkans, J., Newman, T.M., Ying, S., Wakelin, M., Hohenstein, R., Barak, V., Lacy, P., Kay, A.B., Moqbel, R. Immunology (1996) [Pubmed]
  34. Adiponectin is markedly increased in patients with nephrotic syndrome and is related to metabolic risk factors. Zoccali, C., Mallamaci, F., Panuccio, V., Tripepi, G., Cutrupi, S., Parlongo, S., Catalano, F., Tanaka, S., Ouchi, N., Kihara, S., Funahashi, T., Matsuzawa, Y. Kidney Int. Suppl. (2003) [Pubmed]
  35. The hemopoietic growth factor, interleukin-3, promotes glucose transport by increasing the specific activity and maintaining the affinity for glucose of plasma membrane glucose transporters. McCoy, K.D., Ahmed, N., Tan, A.S., Berridge, M.V. J. Biol. Chem. (1997) [Pubmed]
  36. Tissue factor pathway inhibitor in endothelial cells colocalizes with glycolipid microdomains/caveolae. Regulatory mechanism(s) of the anticoagulant properties of the endothelium. Lupu, C., Goodwin, C.A., Westmuckett, A.D., Emeis, J.J., Scully, M.F., Kakkar, V.V., Lupu, F. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  37. Iohexol-induced neutrophil myeloperoxidase release and activation upon contact with vascular stent-graft material: a mechanism contributing to the postimplantation syndrome? Videm, V., Ødegård, A., Myhre, H.O. J. Endovasc. Ther. (2003) [Pubmed]
  38. Proliferative and metastatic potential of exfoliated colorectal cancer cells. Fermor, B., Umpleby, H.C., Lever, J.V., Symes, M.O., Williamson, R.C. J. Natl. Cancer Inst. (1986) [Pubmed]
  39. Encephalopathy after iohexol myelography. Donaghy, M., Fletcher, N.A., Schott, G.D. Lancet (1985) [Pubmed]
  40. Reconstitution of an endosome-lysosome interaction in a cell-free system. Mullock, B.M., Branch, W.J., van Schaik, M., Gilbert, L.K., Luzio, J.P. J. Cell Biol. (1989) [Pubmed]
  41. Retinol-binding protein and asialo-orosomucoid are taken up by different pathways in liver cells. Malaba, L., Smeland, S., Senoo, H., Norum, K.R., Berg, T., Blomhoff, R., Kindberg, G.M. J. Biol. Chem. (1995) [Pubmed]
  42. The heterotrimeric G-protein Gi is localized to the insulin secretory granules of beta-cells and is involved in insulin exocytosis. Konrad, R.J., Young, R.A., Record, R.D., Smith, R.M., Butkerait, P., Manning, D., Jarett, L., Wolf, B.A. J. Biol. Chem. (1995) [Pubmed]
WikiGenes - Universities