The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Peritrate     [3-nitrooxy-2,2- bis(nitrooxymethyl)propyl]...

Synonyms: Duotrate, Erynitum, Kaytrate, Metranil, Mikardol, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.




  • The unique capability of secondary electrospray ionization (SESI) as a nonradioactive ionization source to detect analytes in both liquid and gaseous samples was evaluated using aqueous solutions of three common military explosives: cyclo-1,3,5-trimethylene-2,4,6-trinitramine (RDX), nitroglycerin (NG) and pentaerythritol tetranitrate (PETN) [3].
  • GTN reductase and PETN reductase were very similar in many respects except in their distinct preferences for NADH and NADPH cofactors, respectively [4].
  • Carbocromen (200 microM) and chrysin (50 microM) had no effect, while NAS (1 mM) abolished the increase in nitrine production and iNOS protein abundance in cultured VSMC exposed to interleukin-1 beta (IL-1 beta, 60 U/ml) or the adenyl cyclase activator forskolin (10 microM) [5].
  • In cultured endothelial cells derived from human umbilical vein, the active PETN metabolite PETriN (0.01-1 mM) increased heme oxygenase (HO)-1 mRNA and protein levels in a concentration-dependent fashion [6].
  • Increased HO-1 expression and ensuing formation of cytoprotective bilirubin may contribute to and explain the specific antioxidant and antiatherogenic actions of PETN [6].





Associations of PENTAERYTHRITOL TETRANITRATE with other chemical compounds




Analytical, diagnostic and therapeutic context of PENTAERYTHRITOL TETRANITRATE

  • HPLC in combination with chemoluminescence-N-detection (CLND) is very useful for the analysis of pentaerythrityl tetranitrate (PETN) and its possible biological and chemical degradation products pentaerythrityl trinitrate (PETriN), pentaerythrityl dinitrate (PEDiN) and pentaerythrityl mononitrate (PEMonoN) [18].
  • Quantitative determination of pentaerythrityl tetranitrate and its metabolites in human plasma by gas chromatography/mass spectrometry [9].


  1. Blast-induced neurotrauma in whales. Knudsen, S.K., Øen, E.O. Neurosci. Res. (2003) [Pubmed]
  2. In vivo effects of pentaerythrityl-tetranitrate and isosorbide-5-mononitrate on the development of atherosclerosis and endothelial dysfunction in cholesterol-fed rabbits. Kojda, G., Stein, D., Kottenberg, E., Schnaith, E.M., Noack, E. J. Cardiovasc. Pharmacol. (1995) [Pubmed]
  3. Secondary electrospray ionization-ion mobility spectrometry for explosive vapor detection. Tam, M., Hill, H.H. Anal. Chem. (2004) [Pubmed]
  4. Purification, properties, and sequence of glycerol trinitrate reductase from Agrobacterium radiobacter. Snape, J.R., Walkley, N.A., Morby, A.P., Nicklin, S., White, G.F. J. Bacteriol. (1997) [Pubmed]
  5. Antioxidants differentially affect nuclear factor kappa B-mediated nitric oxide synthase expression in vascular smooth muscle cells. Hecker, M., Preiss, C., Schini-Kerth, V.B., Busse, R. FEBS Lett. (1996) [Pubmed]
  6. Heme oxygenase-1 induction may explain the antioxidant profile of pentaerythrityl trinitrate. Oberle, S., Abate, A., Grosser, N., Vreman, H.J., Dennery, P.A., Schneider, H.T., Stalleicken, D., Schröder, H. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  7. Absorption and bioavailability of pentaerithrityl-tetranitrate (PETN, Dilcoran 80). Haustein, K.O., Winkler, U., Löffler, A., Hüller, G. International journal of clinical pharmacology and therapeutics. (1995) [Pubmed]
  8. Endothelial protection by pentaerithrityl trinitrate: bilirubin and carbon monoxide as possible mediators. Oberle, S., Abate, A., Grosser, N., Hemmerle, A., Vreman, H.J., Dennery, P.A., Schneider, H.T., Stalleicken, D., Schröder, H. Exp. Biol. Med. (Maywood) (2003) [Pubmed]
  9. Quantitative determination of pentaerythrityl tetranitrate and its metabolites in human plasma by gas chromatography/mass spectrometry. Stalleicken, D., Kuntze, U., Schmid, B., Hiebl, R., Ring, J., Michaelis, K. Arzneimittel-Forschung. (1997) [Pubmed]
  10. The antioxidant defense protein ferritin is a novel and specific target for pentaerithrityl tetranitrate in endothelial cells. Oberle, S., Schwartz, P., Abate, A., Schröder, H. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  11. Pentaerithrityl tetranitrate and its phase I metabolites are potent activators of cellular cyclic GMP accumulation. Hinz, B., Kuntze, U., Schröder, H. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  12. Sperm penetration into cervical mucus in vitro. II. Human spermatozoa in bovine mucus. Gaddum-Rosse, P., Blandau, R.J., Lee, W.I. Fertil. Steril. (1980) [Pubmed]
  13. The effect of pentaerithrityl-tetranitrate on parameters of the microcirculation. Böhm, C., Haustein, K.O. International journal of clinical pharmacology and therapeutics. (1998) [Pubmed]
  14. Beneficial effect of pentaerythrityl tetranitrate on functional and morphological changes in the rat thoracic aorta evoked by long-term nitric oxide synthase inhibition. Török, J., Kristek, F. Vascul. Pharmacol. (2002) [Pubmed]
  15. Long-term effect of molsidomine and pentaerythrityl tetranitrate on cardiovascular system of spontaneously hypertensive rats. Kristek, F., Fáberová, V., Varga, I. Physiological research / Academia Scientiarum Bohemoslovaca. (2003) [Pubmed]
  16. Mitochondrial oxidative stress and nitrate tolerance - comparison of nitroglycerin and pentaerithrityl tetranitrate in Mn-SOD+/- mice. Mollnau, H., Wenzel, P., Oelze, M., Treiber, N., Pautz, A., Schulz, E., Schuhmacher, S., Reifenberg, K., Stalleicken, D., Scharffetter-Kochanek, K., Kleinert, H., M??nzel, T., Daiber, A. BMC cardiovascular disorders (2006) [Pubmed]
  17. Pharmacokinetics and bioavailability of pentaerithrityl tetranitrate and two of its metabolites. Weber, W., Michaelis, K., Luckow, V., Kuntze, U., Stalleicken, D. Arzneimittel-Forschung. (1995) [Pubmed]
  18. NO-donors, part X [1] : investigations on the stability of pentaerythrityl tetranitrate (PETN) by HPLC-chemoluminescence-N-detection (CLND) versus UV-detection in HPLC. Seeling, A., Lehmann, J. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
WikiGenes - Universities