Gene Review:
GPR39 - G protein-coupled receptor 39
Homo sapiens
Synonyms:
G-protein coupled receptor 39
- The obestatin receptor (GPR39) is expressed in human adipose tissue and is down-regulated in obesity-associated type 2 diabetes mellitus. Catalán, V., Gómez-Ambrosi, J., Rotellar, F., Silva, C., Gil, M.J., Rodríguez, A., Cienfuegos, J.A., Salvador, J., Frühbeck, G. Clin. Endocrinol. (Oxf) (2007)
- Common structural basis for constitutive activity of the ghrelin receptor family. Holst, B., Holliday, N.D., Bach, A., Elling, C.E., Cox, H.M., Schwartz, T.W. J. Biol. Chem. (2004)
- GPR39 Signaling Is Stimulated by Zinc Ions But Not by Obestatin. Holst, B., Egerod, K.L., Schild, E., Vickers, S.P., Cheetham, S., Gerlach, L.O., Storjohann, L., Stidsen, C.E., Jones, R., Beck-Sickinger, A.G., Schwartz, T.W. Endocrinology (2007)
- Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors. McKee, K.K., Tan, C.P., Palyha, O.C., Liu, J., Feighner, S.D., Hreniuk, D.L., Smith, R.G., Howard, A.D., Van der Ploeg, L.H. Genomics (1997)
- Growth hormone releasing substances: types and their receptors. Smith, R.G., Palyha, O.C., Feighner, S.D., Tan, C.P., McKee, K.K., Hreniuk, D.L., Yang, L., Morriello, G., Nargund, R., Patchett, A.A., Howard, A.D. Horm. Res. (1999)
- Obestatin does not activate orphan G protein-coupled receptor GPR39. Lauwers, E., Landuyt, B., Arckens, L., Schoofs, L., Luyten, W. Biochem. Biophys. Res. Commun. (2006)
- Obestatin acts in brain to inhibit thirst. Samson, W.K., White, M.M., Price, C., Ferguson, A.V. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2007)
- Relative gene-silencing efficiencies of small interfering RNAs targeting sense and antisense transcripts from the same genetic locus. Hu, X., Hipolito, S., Lynn, R., Abraham, V., Ramos, S., Wong-Staal, F. Nucleic Acids Res. (2004)
- GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue. Egerod, K.L., Holst, B., Petersen, P.S., Hansen, J.B., Mulder, J., Hökfelt, T., Schwartz, T.W. Mol. Endocrinol. (2007)