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Gene Review

IGKV2-29  -  immunoglobulin kappa variable 2-29...

Homo sapiens

Synonyms: A18, A18b, IGKV229
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Disease relevance of IGKV2-29

  • Polymorphism in the IGKV2-29 gene was shown to decrease the recombination frequency in B cells and to be important for immune responses to Haemophilus influenzae type b polysaccharide [1].
  • RmcB did not protect HeLa cells from infection by poliovirus, echovirus 6, or coxsackievirus A18 [2].
  • Thus, despite the sequence similarity between A2 and A18, only A2 contributes to the canonical Hib PS paratope [3].
  • MLSSR analysis was also clearly able to distinguish between sheep and cattle isolates of M. paratuberculosis and easily and reproducibly differentiated strains representing the predominant MPIL genotype (genotype A18) and AFLP genotypes (genotypes Z1 and Z2) of M. paratuberculosis described previously [4].
  • Based on our preliminary clinical data, we came to the conclusion that both A18 and A21 could possibly be used in the prognosis of breast cancer [5].

High impact information on IGKV2-29

  • The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response [6].
  • Using the hamster A18 partial-length cDNA as a probe, we screened human fibroblast cDNA library and isolated the corresponding full-length human cDNA [7].
  • The DDI clones A18, 106, and A107 were different isolates of the same hamster cDNA (hereafter referred to as A18) and displayed high sequence homology with the members in the heterogeneous ribonucleoprotein (hnRNP) family [7].
  • Since purine 18 does not form a base-pair in the non-specific purine trap, both purines, G18 and A18, fit to the structure equally well [8].
  • Polysaccharide binding potential of the human A2 or A18 kappa light chain homologues [3].

Biological context of IGKV2-29

  • The A18 mRNA levels were specifically increased in response to DNA damage induced by UV irradiation or UV mimetic agents [7].
  • DNA fingerprinting and restriction fragment length polymorphism (RFLP) analysis results confirmed that C4:2 was of the same lineage as A18 [9].
  • Thus, in the presence of 10(-9) M D4 bimAb, protein synthesis was inhibited with an IC50 of 5 x 10(-10) M as gelonin, whereas with A18 bimAb the IC50 was 8 x 10(-11) M [10].
  • The A18b allele that was recently described in Native American Navajos by Atkinson et al. was found in all three populations with gene frequencies of 8%, 45% and 23% in Caucasians, Eskimos and blacks, respectively [11].
  • Moreover, down regulation of hnRNP A18 correlates with a significant reduction of TRX protein levels [12].

Anatomical context of IGKV2-29

  • The functionality of the A18b allele was documented by the demonstration of properly rearranged and somatically hypermutated A18b messenger RNA present in the blood lymphocytes of individuals carrying this allele [11].
  • An A15, an A18, and an A24 wide-field amacrine cell were stained [13].
  • Of the 48 patients with a normal size left ventricle on echocardiography, 25.58% had measurement A 18 mm and above, and 13.95% had a value 19 mm and above [14].
  • In the adult cat, axons running through the corpus callosum interconnect the border between the visual cortical areas 17 and 18 (A17 and A18) of both hemispheres [15].

Associations of IGKV2-29 with chemical compounds

  • To investigate the activities of these P450 family enzymes in the murine ES cell-derived hepatic tissue system at A16 and A18, testosterone metabolism in this system was analyzed [16].
  • Here, we show that the heterogenous ribonucleoprotein A18 (hnRNP A18) RNA Binding Domain (RBD) and the arginine, glycine (RGG) rich domain can bind TRX 3'-untranslated region (3'-UTR) independently but both domains are required for maximal binding [12].

Other interactions of IGKV2-29


Analytical, diagnostic and therapeutic context of IGKV2-29


  1. Distribution of human kappa locus IGKV2-29 and IGKV2D-29 alleles in Swedish Caucasians and Hong Kong Chinese. Padyukov, L., Hahn-Zoric, M., Blomqvist, S.R., Ulanova, M., Welch, S.G., Feeney, A.J., Lau, Y.L., Hanson, L.A. Immunogenetics (2001) [Pubmed]
  2. A monoclonal antibody specific for the cellular receptor for the group B coxsackieviruses. Hsu, K.H., Lonberg-Holm, K., Alstein, B., Crowell, R.L. J. Virol. (1988) [Pubmed]
  3. Polysaccharide binding potential of the human A2 or A18 kappa light chain homologues. Reason, D.C., Wagner, T.C., Tang, V.R., Moulton, K.D., Lucas, A.H. Infect. Immun. (1999) [Pubmed]
  4. Multilocus short sequence repeat sequencing approach for differentiating among Mycobacterium avium subsp. paratuberculosis strains. Amonsin, A., Li, L.L., Zhang, Q., Bannantine, J.P., Motiwala, A.S., Sreevatsan, S., Kapur, V. J. Clin. Microbiol. (2004) [Pubmed]
  5. Characterization and utilization of two novel anti-erbB-2 monoclonal antibodies in detection of soluble ErbB-2 for breast cancer prognosis. Li, P., Li, Y., Li, J.Y., Liu, J. Cancer Lett. (2003) [Pubmed]
  6. The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response. Yang, C., Carrier, F. J. Biol. Chem. (2001) [Pubmed]
  7. Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein. Sheikh, M.S., Carrier, F., Papathanasiou, M.A., Hollander, M.C., Zhan, Q., Yu, K., Fornace, A.J. J. Biol. Chem. (1997) [Pubmed]
  8. Specific and non-specific purine trap in the T-loop of normal and suppressor tRNAs. Doyon, F.R., Zagryadskaya, E.I., Chen, J., Steinberg, S.V. J. Mol. Biol. (2004) [Pubmed]
  9. Methylation of CpG island is not a ubiquitous mechanism for the loss of oestrogen receptor in breast cancer cells. Chen, Z., Ko, A., Yang, J., Jordan, V.C. Br. J. Cancer (1998) [Pubmed]
  10. Differential sensitivity of CD30+ neoplastic cells to gelonin delivered by anti-CD30/anti-gelonin bispecific antibodies. Sforzini, S., Bolognesi, A., Meazza, R., Marciano, S., Casalini, P., Dürkop, H., Tazzari, P.L., Stein, H., Stirpe, F., Ferrini, S. Br. J. Haematol. (1995) [Pubmed]
  11. Population studies of the human V kappa A18 gene polymorphism in Caucasians, blacks and Eskimos. New functional alleles and evidence for evolutionary selection of a more restricted antibody repertoire. Juul, L., Hougs, L., Andersen, V., Garred, P., Ryder, L., Svejgaard, A., Høgh, B., Lamm, L., Graugaard, B., Barington, T. Tissue Antigens (1997) [Pubmed]
  12. Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18. Yang, R., Weber, D.J., Carrier, F. Nucleic Acids Res. (2006) [Pubmed]
  13. UV responses in the retina of the turtle. Ventura, D.F., de Souza, J.M., Devoe, R.D., Zana, Y. Vis. Neurosci. (1999) [Pubmed]
  14. Evaluation of left ventricular enlargement in the lateral position of the chest using the Hoffman and Rigler sign. Freeman, V., Mutatiri, C., Pretorius, M., Doubell, A. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners. (2003) [Pubmed]
  15. Microglia and astrocytes may participate in the shaping of visual callosal projections during postnatal development. Rochefort, N., Quenech'du, N., Watroba, L., Mallat, M., Giaume, C., Milleret, C. J. Physiol. Paris (2002) [Pubmed]
  16. Characterization of cytochrome P450 expression in murine embryonic stem cell-derived hepatic tissue system. Tsutsui, M., Ogawa, S., Inada, Y., Tomioka, E., Kamiyoshi, A., Tanaka, S., Kishida, T., Nishiyama, M., Murakami, M., Kuroda, J., Hashikura, Y., Miyagawa, S., Satoh, F., Shibata, N., Tagawa, Y. Drug Metab. Dispos. (2006) [Pubmed]
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