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Gene Review

GRM7  -  glutamate receptor, metabotropic 7

Homo sapiens

Synonyms: GLUR7, GPRC1G, MGLU7, MGLUR7, Metabotropic glutamate receptor 7, ...
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Disease relevance of GRM7

  • The Tyr433Phe polymorphism of mGluR7 and a novel polymorphism in the mGluR8 gene located 29 bp after the termination codon (2756C/T) were investigated in case control association studies performed on DNA from more than 100 patients with idiopathic generalised epilepsy (IGE) [1].
  • The mGluR7 cytoplasmic domain appended to the transmembrane portion of the vesicular stomatitis virus G protein and the ectodomain of human placental alkaline phosphatase is distributed over the entire cell surface in cultured neurons [2].

Psychiatry related information on GRM7


High impact information on GRM7


Biological context of GRM7


Anatomical context of GRM7

  • In-situ hybridization studies on human brain sections showed that mGluR7 mRNA has a widespread distribution with highest levels in the hippocampal formation, cerebral cortex and cerebellum [8].
  • A total of 182 patients meeting DSM-IV alcohol dependence criteria and 117 controls, both groups being of German descent, were investigated. mGluR7 and mGluR8 polymorphisms were determined using polymerase chain reaction of lymphocyte DNA [9].
  • We show a relationship between these three proteins using recombinant PICK1, mGluR7, and PKCalpha, where they were co-immunoprecipitated as a complex from COS-7 cells [10].
  • Truncation of the mGluR7 cytoplasmic tail produces a protein that is restricted to a perinuclear intracellular compartment in both neurons and MDCK cells, where this protein colocalizes with a trans-Golgi network antigen [2].
  • Thus, AMN082 will be effective for investigating physiological processes related to both mGluR7 activation and internalization such as control of bidirectional plasticity at mossy fiber-st. lucidum interneuron synapses [11].

Associations of GRM7 with chemical compounds


Regulatory relationships of GRM7

  • We have previously shown that the interaction of Ca(2+)/calmodulin with the metabotropic glutamate receptor type 7 (mGluR7) promotes the G-protein-mediated inhibition of voltage-sensitive Ca(2+) channels (VSCCs) seen upon agonist activation [16].

Other interactions of GRM7


Analytical, diagnostic and therapeutic context of GRM7


  1. No association found between polymorphisms in genes encoding mGluR7 and mGluR8 and idiopathic generalised epilepsy in a case control study. Goodwin, H., Curran, N., Chioza, B., Blower, J., Nashef, L., Asherson, P., Makoff, A.J. Epilepsy Res. (2000) [Pubmed]
  2. The C-terminal tail of the metabotropic glutamate receptor subtype 7 is necessary but not sufficient for cell surface delivery and polarized targeting in neurons and epithelia. McCarthy, J.B., Lim, S.T., Elkind, N.B., Trimmer, J.S., Duvoisin, R.M., Rodriguez-Boulan, E., Caplan, M.J. J. Biol. Chem. (2001) [Pubmed]
  3. Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder. Kobayashi, Y., Akiyoshi, J., Kanehisa, M., Ichioka, S., Tanaka, Y., Tsuru, J., Hanada, H., Kodama, K., Isogawa, K., Tsutsumi, T. Psychiatr. Genet. (2007) [Pubmed]
  4. A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Mitsukawa, K., Yamamoto, R., Ofner, S., Nozulak, J., Pescott, O., Lukic, S., Stoehr, N., Mombereau, C., Kuhn, R., McAllister, K.H., van der Putten, H., Cryan, J.F., Flor, P.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  5. Epigenetic profiling in chronic lymphocytic leukemia reveals novel methylation targets. Rush, L.J., Raval, A., Funchain, P., Johnson, A.J., Smith, L., Lucas, D.M., Bembea, M., Liu, T.H., Heerema, N.A., Rassenti, L., Liyanarachchi, S., Davuluri, R., Byrd, J.C., Plass, C. Cancer Res. (2004) [Pubmed]
  6. Assignment of the human metabotropic glutamate receptor gene GRM7 to chromosome 3p26.1-->p25.2 by radiation hybrid mapping. Barbon, A., Ferraboli, S., Barlati, S. Cytogenet. Cell Genet. (2000) [Pubmed]
  7. Polymorphisms in the genes for mGluR types 7 and 8: association studies with schizophrenia. Bolonna, A.A., Kerwin, R.W., Munro, J., Arranz, M.J., Makoff, A.J. Schizophr. Res. (2001) [Pubmed]
  8. Human metabotropic glutamate receptor type 7: molecular cloning and mRNA distribution in the CNS. Makoff, A., Pilling, C., Harrington, K., Emson, P. Brain Res. Mol. Brain Res. (1996) [Pubmed]
  9. No association between metabotropic glutamate receptors 7 and 8 (mGlur7 and mGlur8) gene polymorphisms and withdrawal seizures and delirium tremens in alcohol-dependent individuals. Preuss, U.W., Koller, G., Bahlmann, M., Zill, P., Soyka, M., Bondy, B. Alcohol Alcohol. (2002) [Pubmed]
  10. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. Dev, K.K., Nakajima, Y., Kitano, J., Braithwaite, S.P., Henley, J.M., Nakanishi, S. J. Neurosci. (2000) [Pubmed]
  11. mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082. Pelkey, K.A., Yuan, X., Lavezzari, G., Roche, K.W., McBain, C.J. Neuropharmacology (2007) [Pubmed]
  12. A novel splice variant of a metabotropic glutamate receptor, human mGluR7b. Flor, P.J., Van Der Putten, H., Rüegg, D., Lukic, S., Leonhardt, T., Bence, M., Sansig, G., Knöpfel, T., Kuhn, R. Neuropharmacology (1997) [Pubmed]
  13. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Kingston, A.E., Ornstein, P.L., Wright, R.A., Johnson, B.G., Mayne, N.G., Burnett, J.P., Belagaje, R., Wu, S., Schoepp, D.D. Neuropharmacology (1998) [Pubmed]
  14. LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors. Schoepp, D.D., Johnson, B.G., Wright, R.A., Salhoff, C.R., Mayne, N.G., Wu, S., Cockerman, S.L., Burnett, J.P., Belegaje, R., Bleakman, D., Monn, J.A. Neuropharmacology (1997) [Pubmed]
  15. Dissociation of protein kinase-mediated regulation of metabotropic glutamate receptor 7 (mGluR7) interactions with calmodulin and regulation of mGluR7 function. Sorensen, S.D., Macek, T.A., Cai, Z., Saugstad, J.A., Conn, P.J. Mol. Pharmacol. (2002) [Pubmed]
  16. MacMARCKS interacts with the metabotropic glutamate receptor type 7 and modulates G protein-mediated constitutive inhibition of calcium channels. Bertaso, F., Lill, Y., Airas, J.M., Espeut, J., Blahos, J., Bockaert, J., Fagni, L., Betz, H., El Far, O. J. Neurochem. (2006) [Pubmed]
  17. Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7). Schulz, H.L., Stohr, H., Weber, B.H. Neurosci. Lett. (2002) [Pubmed]
  18. Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells. Wu, S., Wright, R.A., Rockey, P.K., Burgett, S.G., Arnold, J.S., Rosteck, P.R., Johnson, B.G., Schoepp, D.D., Belagaje, R.M. Brain Res. Mol. Brain Res. (1998) [Pubmed]
  19. Molecular diversity of glutamate receptors and their physiological functions. Nakanishi, S., Masu, M., Bessho, Y., Nakajima, Y., Hayashi, Y., Shigemoto, R. EXS. (1994) [Pubmed]
  20. Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies. Phillips, T., Makoff, A., Murrison, E., Mimmack, M., Waldvogel, H., Faull, R., Rees, S., Emson, P. Brain Res. Mol. Brain Res. (1998) [Pubmed]
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