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Chemical Compound Review

Aminoadipate     (2S)-2-aminohexanedioic acid

Synonyms: h-aad-oh, h-2-aad-oh, AmbotzHAA1089, h-l-2-aad-oh, CHEMBL88804, ...
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Analytical, diagnostic and therapeutic context of C00956


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  2. L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture. Chang, Y.F., Cauley, R.K., Chang, J.D., Rao, V.V. Neurochem. Res. (1997) [Pubmed]
  3. Production of N-acetylisopenicillin N and isopenicillin N from Streptomyces tokunonensis sp. nov. Shoji, J., Hinoo, H., Sakazaki, R., Kato, T., Matsumoto, K., Takahashi, Y., Kondo, E. J. Antibiot. (1982) [Pubmed]
  4. The glutamate analogue alpha-aminoadipic acid is taken up by astrocytes before exerting its gliotoxic effect in vitro. Huck, S., Grass, F., Hörtnagl, H. J. Neurosci. (1984) [Pubmed]
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  15. Comparison of excitatory amino acid-stimulated phosphoinositide hydrolysis and N-[3H]acetylaspartylglutamate binding in rat brain: selective inhibition of phosphoinositide hydrolysis by 2-amino-3-phosphonopropionate. Schoepp, D.D., Johnson, B.G. J. Neurochem. (1989) [Pubmed]
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  20. Catabolism of lysine in Penicillium chrysogenum leads to formation of 2-aminoadipic acid, a precursor of penicillin biosynthesis. Esmahan, C., Alvarez, E., Montenegro, E., Martin, J.F. Appl. Environ. Microbiol. (1994) [Pubmed]
  21. Gliotoxic actions of excitatory amino acids. Bridges, R.J., Hatalski, C.G., Shim, S.N., Cummings, B.J., Vijayan, V., Kundi, A., Cotman, C.W. Neuropharmacology (1992) [Pubmed]
  22. Influence of the glia limitans on pial arteriolar relaxation in the rat. Xu, H.L., Koenig, H.M., Ye, S., Feinstein, D.L., Pelligrino, D.A. Am. J. Physiol. Heart Circ. Physiol. (2004) [Pubmed]
  23. Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate. McBean, G.J. Br. J. Pharmacol. (1994) [Pubmed]
  24. Gliotoxic effects of alpha-aminoadipic acid isomers on the carp retina: a long term observation. Kato, S., Sugawara, K., Matsukawa, T., Negishi, K. Neuroscience (1990) [Pubmed]
  25. Glutamate uptake by rat brain astroglia incubated in human cerebrospinal fluid. Colombo, J.A. Med. Sci. Monit. (2005) [Pubmed]
  26. L-pipecolic acid metabolism in human liver: L-alpha-aminoadipate delta-semialdehyde oxidoreductase. Chang, Y.F., Ghosh, P., Rao, V.V. Biochim. Biophys. Acta (1990) [Pubmed]
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