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Gene Review

Myod1  -  myogenic differentiation 1

Rattus norvegicus

Synonyms: Myoblast determination protein 1, Myod
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Disease relevance of Myod1


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Chemical compound and disease context of Myod1


Biological context of Myod1


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Regulatory relationships of Myod1


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Analytical, diagnostic and therapeutic context of Myod1


  1. Inhibition of muscle differentiation by the adenovirus E1a protein: repression of the transcriptional activating function of the HLH protein Myf-5. Braun, T., Bober, E., Arnold, H.H. Genes Dev. (1992) [Pubmed]
  2. Retinoic acid induces myogenin synthesis and myogenic differentiation in the rat rhabdomyosarcoma cell line BA-Han-1C. Arnold, H.H., Gerharz, C.D., Gabbert, H.E., Salminen, A. J. Cell Biol. (1992) [Pubmed]
  3. Rat model of the human "Triton" tumor: direct genetic evidence for the myogenic differentiation capacity of schwannoma cells using the mutant neu gene as a cell lineage marker. Nikitin AYu, n.u.l.l., Lennartz, K., Pozharisski, K.M., Rajewsky, M.F. Differentiation (1991) [Pubmed]
  4. Proliferation precedes differentiation in IGF-I-stimulated myogenesis. Engert, J.C., Berglund, E.B., Rosenthal, N. J. Cell Biol. (1996) [Pubmed]
  5. Expression of PDGF A-chain and beta-receptor genes during rat myoblast differentiation. Jin, P., Rahm, M., Claesson-Welsh, L., Heldin, C.H., Sejersen, T. J. Cell Biol. (1990) [Pubmed]
  6. Generation of a stable, posttranslationally modified microtubule array is an early event in myogenic differentiation. Gundersen, G.G., Khawaja, S., Bulinski, J.C. J. Cell Biol. (1989) [Pubmed]
  7. Transforming growth factor beta induces myoblast differentiation in the presence of mitogens. Zentella, A., Massagué, J. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  8. Cell adhesion to collagen and decreased myogenic gene expression implicated in the control of myogenesis by transforming growth factor beta. Heino, J., Massagué, J. J. Biol. Chem. (1990) [Pubmed]
  9. Insulin-like growth factor-I stimulates terminal myogenic differentiation by induction of myogenin gene expression. Florini, J.R., Ewton, D.Z., Roof, S.L. Mol. Endocrinol. (1991) [Pubmed]
  10. Akt phosphorylation is not sufficient for insulin-like growth factor-stimulated myogenin expression but must be accompanied by down-regulation of mitogen-activated protein kinase/extracellular signal-regulated kinase phosphorylation. Tiffin, N., Adi, S., Stokoe, D., Wu, N.Y., Rosenthal, S.M. Endocrinology (2004) [Pubmed]
  11. Regulation of c-jun/AP-1 expression in rat L6 myoblasts. Thinakaran, G., Bag, J. Biochem. Cell Biol. (1993) [Pubmed]
  12. The kinase inhibitor iso-H7 stimulates rat satellite cell differentiation through a non-protein kinase C pathway by increasing myogenin expression level. Lagord, C., Leibovitch, M.P., Carpentier, G., Leibovitch, S.A., Martelly, I. Cell Biol. Toxicol. (1996) [Pubmed]
  13. S100B inhibits myogenic differentiation and myotube formation in a RAGE-independent manner. Sorci, G., Riuzzi, F., Agneletti, A.L., Marchetti, C., Donato, R. Mol. Cell. Biol. (2003) [Pubmed]
  14. Highly specific inhibition of IGF-I-stimulated differentiation by an antisense oligodeoxyribonucleotide to myogenin mRNA. No effects on other actions of IGF-T. Florini, J.R., Ewton, D.Z. J. Biol. Chem. (1990) [Pubmed]
  15. Signals from damaged but not undamaged skeletal muscle induce myogenic differentiation of rat bone-marrow-derived mesenchymal stem cells. Santa María, L., Rojas, C.V., Minguell, J.J. Exp. Cell Res. (2004) [Pubmed]
  16. Differentiation-dependent regulation of skeletal myogenesis by neuregulin-1. Ford, B.D., Han, B., Fischbach, G.D. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
  17. Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. Kaliman, P., Viñals, F., Testar, X., Palacín, M., Zorzano, A. J. Biol. Chem. (1996) [Pubmed]
  18. Alteration of the C-terminal amino acid of tubulin specifically inhibits myogenic differentiation. Chang, W., Webster, D.R., Salam, A.A., Gruber, D., Prasad, A., Eiserich, J.P., Bulinski, J.C. J. Biol. Chem. (2002) [Pubmed]
  19. Myogenic signaling by lithium in cardiomyoblasts is Akt independent but requires activation of the beta-catenin-Tcf/Lef pathway. Kashour, T., Burton, T., Dibrov, A., Amara, F. J. Mol. Cell. Cardiol. (2003) [Pubmed]
  20. A novel role of neuregulin in skeletal muscle. Neuregulin stimulates glucose uptake, glucose transporter translocation, and transporter expression in muscle cells. Suárez, E., Bach, D., Cadefau, J., Palacin, M., Zorzano, A., Gumá, A. J. Biol. Chem. (2001) [Pubmed]
  21. Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway. Guillet-Deniau, I., Burnol, A.F., Girard, J. J. Biol. Chem. (1997) [Pubmed]
  22. BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation. Mousavi, K., Jasmin, B.J. J. Neurosci. (2006) [Pubmed]
  23. IGF-I-induced differentiation of L6 myogenic cells requires the activity of cAMP-phosphodiesterase. De Arcangelis, V., Coletti, D., Conti, M., Lagarde, M., Molinaro, M., Adamo, S., Nemoz, G., Naro, F. Mol. Biol. Cell (2003) [Pubmed]
  24. Neuregulin stimulates myogenic differentiation in an autocrine manner. Kim, D., Chi, S., Lee, K.H., Rhee, S., Kwon, Y.K., Chung, C.H., Kwon, H., Kang, M.S. J. Biol. Chem. (1999) [Pubmed]
  25. "Spontaneous" differentiation of skeletal myoblasts is dependent upon autocrine secretion of insulin-like growth factor-II. Florini, J.R., Magri, K.A., Ewton, D.Z., James, P.L., Grindstaff, K., Rotwein, P.S. J. Biol. Chem. (1991) [Pubmed]
  26. SV40 T antigen inhibits expression of MyoD and myogenin, up-regulates Myf-5, but does not affect early expression of desmin or alpha 7 integrin during muscle development. Haider, S.R., Wang, W., Kaufman, S.J. Exp. Cell Res. (1994) [Pubmed]
  27. Phospholipase D is involved in myogenic differentiation through remodeling of actin cytoskeleton. Komati, H., Naro, F., Mebarek, S., De Arcangelis, V., Adamo, S., Lagarde, M., Prigent, A.F., Némoz, G. Mol. Biol. Cell (2005) [Pubmed]
  28. Up-regulation of nuclear PLCbeta1 in myogenic differentiation. Faenza, I., Bavelloni, A., Fiume, R., Lattanzi, G., Maraldi, N.M., Gilmour, R.S., Martelli, A.M., Suh, P.G., Billi, A.M., Cocco, L. J. Cell. Physiol. (2003) [Pubmed]
  29. Transcriptional and posttranscriptional control of c-myc during myogenesis: its mRNA remains inducible in differentiated cells and does not suppress the differentiated phenotype. Endo, T., Nadal-Ginard, B. Mol. Cell. Biol. (1986) [Pubmed]
  30. Jun, Fos, MyoD1, and myogenin proteins are increased in skeletal muscle fiber nuclei after denervation. Weis, J. Acta Neuropathol. (1994) [Pubmed]
  31. Correlation between cell differentiation stage, types of invasion, and hematogenous metastasis in experimental rhabdomyosarcomas. Herrera-Gayol, A., Royal, A., Babaï, F. Exp. Mol. Pathol. (1995) [Pubmed]
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