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Gene Review

Ptprn2  -  protein tyrosine phosphatase, receptor...

Rattus norvegicus

Synonyms: PTP NE-6, PTPNE6, Phogrin, R-PTP-N2, Receptor-type tyrosine-protein phosphatase N2
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Disease relevance of Ptprn2

  • An insulin granule membrane protein-tyrosine phosphatase (PTP) homologue, phogrin, was cloned by expression screening of a rat insulinoma cDNA library [1].
  • Antibodies to phogrin were detected in sera from patients with IDDM, and these antibodies were strongly correlated with the presence of antibodies to the 37-kDa antigen [2].

High impact information on Ptprn2


Chemical compound and disease context of Ptprn2

  • Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2 [2].
  • To image the behaviour in real time of single secretory granules in neuroendocrine cells we have expressed cDNA encoding a fusion construct between the dense-core secretory-granule-membrane glycoprotein, phogrin (phosphatase on the granule of insulinoma cells), and enhanced green fluorescent protein (EGFP) [5].

Biological context of Ptprn2


Anatomical context of Ptprn2


Associations of Ptprn2 with chemical compounds


Other interactions of Ptprn2

  • A receptor-type protein tyrosine phosphatase, PTP NE-6, was identified from rat olfactory epithelial cDNA and cloned from a rat brain cDNA library [6].
  • In situ experiments in rat brain showing the distribution of IA-2 and phogrin suggested a complimentary and overlapping pattern compared with the proprotein convertases PC1 and PC2 [7].

Analytical, diagnostic and therapeutic context of Ptprn2


  1. Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes. Wasmeier, C., Hutton, J.C. J. Biol. Chem. (1996) [Pubmed]
  2. Identification of the 37-kDa antigen in IDDM as a tyrosine phosphatase-like protein (phogrin) related to IA-2. Hawkes, C.J., Wasmeier, C., Christie, M.R., Hutton, J.C. Diabetes (1996) [Pubmed]
  3. Secretory granules are recaptured largely intact after stimulated exocytosis in cultured endocrine cells. Taraska, J.W., Perrais, D., Ohara-Imaizumi, M., Nagamatsu, S., Almers, W. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Different regulated expression of the tyrosine phosphatase-like proteins IA-2 and phogrin by glucose and insulin in pancreatic islets: relationship to development of insulin secretory responses in early life. Löbner, K., Steinbrenner, H., Roberts, G.A., Ling, Z., Huang, G.C., Piquer, S., Pipeleers, D.G., Seissler, J., Christie, M.R. Diabetes (2002) [Pubmed]
  5. Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera. Pouli, A.E., Emmanouilidou, E., Zhao, C., Wasmeier, C., Hutton, J.C., Rutter, G.A. Biochem. J. (1998) [Pubmed]
  6. PTP NE-6: a brain-enriched receptor-type protein tyrosine phosphatase with a divergent catalytic domain. Fitzgerald, L.R., Walton, K.M., Dixon, J.E., Largent, B.L. J. Neurochem. (1997) [Pubmed]
  7. IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm. Zahn, T.R., Macmorris, M.A., Dong, W., Day, R., Hutton, J.C. J. Comp. Neurol. (2001) [Pubmed]
  8. Autoantibodies to protein tyrosine phosphatase-like proteins in type I diabetes. Overlapping specificities to phogrin and ICA512/IA-2. Kawasaki, E., Eisenbarth, G.S., Wasmeier, C., Hutton, J.C. Diabetes (1996) [Pubmed]
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