Gene Review:
Ptprn2 - protein tyrosine phosphatase, receptor...
Mus musculus
Synonyms:
4930425H11Rik, IA-2 beta, IA-2beta, IA2beta, PTP IA-2beta, ...
- Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment. Lu, J., Li, Q., Xie, H., Chen, Z.J., Borovitskaya, A.E., Maclaren, N.K., Notkins, A.L., Lan, M.S. Proc. Natl. Acad. Sci. U.S.A. (1996)
- IA-2beta, but not IA-2, is induced by ghrelin and inhibits glucose-stimulated insulin secretion. Doi, A., Shono, T., Nishi, M., Furuta, H., Sasaki, H., Nanjo, K. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility. Kubosaki, A., Nakamura, S., Clark, A., Morris, J.F., Notkins, A.L. Endocrinology (2006)
- PTP-NP, a new member of the receptor protein tyrosine phosphatase family, implicated in development of nervous system and pancreatic endocrine cells. Chiang, M.K., Flanagan, J.G. Development (1996)
- Characterization of antibody responses to endogenous and exogenous antigen in the nonobese diabetic mouse. Koczwara, K., Schenker, M., Schmid, S., Kredel, K., Ziegler, A.G., Bonifacio, E. Clin. Immunol. (2003)
- Secretagogue-dependent phosphorylation of the insulin granule membrane protein phogrin is mediated by cAMP-dependent protein kinase. Wasmeier, C., Hutton, J.C. J. Biol. Chem. (2001)
- Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic beta-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopy. Ohara-Imaizumi, M., Nakamichi, Y., Tanaka, T., Katsuta, H., Ishida, H., Nagamatsu, S. Biochem. J. (2002)
- Secretagogue-dependent phosphorylation of phogrin, an insulin granule membrane protein tyrosine phosphatase homologue. Wasmeier, C., Hutton, J.C. Biochem. J. (1999)
- Recycling of the dense-core vesicle membrane protein phogrin in Min6 beta-cells. Vo, Y.P., Hutton, J.C., Angleson, J.K. Biochem. Biophys. Res. Commun. (2004)
- Dense Core Vesicle Proteins IA-2 and IA-2{beta}: Metabolic Alterations in Double Knockout Mice. Kubosaki, A., Nakamura, S., Notkins, A.L. Diabetes (2005)
- T-cell epitope analysis on the autoantigen phogrin (IA-2beta) in the nonobese diabetic mouse. Kelemen, K., Wegmann, D.R., Hutton, J.C. Diabetes (2001)
- An extended tyrosine-targeting motif for endocytosis and recycling of the dense-core vesicle membrane protein phogrin. Wasmeier, C., Burgos, P.V., Trudeau, T., Davidson, H.W., Hutton, J.C. Traffic (2005)
- Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation. Arden, C., Harbottle, A., Baltrusch, S., Tiedge, M., Agius, L. Diabetes (2004)