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Gene Review

GUCY2C  -  guanylate cyclase 2C

Homo sapiens

Synonyms: DIAR6, GC-C, GUC2C, Guanylyl cyclase C, Heat-stable enterotoxin receptor, ...
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Disease relevance of GUCY2C


High impact information on GUCY2C

  • Stable mammalian cell lines over-expressing the STa receptor specifically bind 125I-STa (Kd approximately 1.0 nM) and respond to STa by dramatically increasing (approximately 50-fold) cellular cGMP levels [4].
  • A 60 kDa protein was also specifically immunoprecipitated from solubilized human brush border membranes using antisera raised against a cloned STa receptor fusion protein [5].
  • Our observations of multiple crosslinked proteins in human intestine and Caco-2 cells could be explained by the existence of several members of a family of STa receptors and/or the existence of smaller STa binding proteins generated by the protease cleavage of a larger complete STa receptor [5].
  • This suggested that a guanine nucleotide regulatory protein (G protein) coupled the STa receptor to guanylate cyclase, a function not previously recognized for G proteins [1].
  • The putative STa receptor was radiolabeled with 431 125I-STa and solubilized with sodium deoxycholate [6].

Biological context of GUCY2C


Anatomical context of GUCY2C


Associations of GUCY2C with chemical compounds

  • Although GC-C, the STa receptor, may also be a receptor for guanylin, other receptors may exist that may be more specific for guanylin.(ABSTRACT TRUNCATED AT 250 WORDS)[13]
  • It is likely that guanylin and uroguanylin are indeed endogenous ligands for the STa receptor and may be modulators of Cl- secretion in the intestine, kidney, and perhaps in other organs [13].
  • D-dimers plasma concentrations were measured with the STA Liatest D-Di on the STA-R coagulation analyzer, with a reference ELISA technique (Asserachrom), with an automated quantitative latex-based immunoassay (Tinaquant) and with the VIDAS D-dimer test [14].
  • The double-leg lowering test was measured in degrees, and the Star Excursion Balance Test was measured in 4 directions as a percentage of the subject's leg length [15].
  • The probability of receiving a Purple Heart, Bronze Star, Commendation Medal and Combat Infantry Badge is associated strongly with the combat exposure index [16].

Physical interactions of GUCY2C

  • Recently an endogenous ligand called guanylin has been extracted from mammalian intestine and shown to bind the STa receptor [13].

Other interactions of GUCY2C


Analytical, diagnostic and therapeutic context of GUCY2C


  1. Failure of pertussis toxin to inhibit activation of guanylate cyclase by the heat-stable enterotoxin of Escherichia coli (STa) in the T84 cell line. Crane, J.K., Hewlett, E.L., Weikel, C.S. Infect. Immun. (1989) [Pubmed]
  2. Measurement in Duchenne muscular dystrophy: considerations in the development of a neuromuscular assessment tool. Scott, E., Mawson, S.J. Developmental medicine and child neurology. (2006) [Pubmed]
  3. A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer. Schulz, S., Hyslop, T., Haaf, J., Bonaccorso, C., Nielsen, K., Witek, M.E., Birbe, R., Palazzo, J., Weinberg, D., Waldman, S.A. Clin. Cancer Res. (2006) [Pubmed]
  4. Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin. de Sauvage, F.J., Camerato, T.R., Goeddel, D.V. J. Biol. Chem. (1991) [Pubmed]
  5. Receptors for Escherichia coli heat stable enterotoxin in human intestine and in a human intestinal cell line (Caco-2). Cohen, M.B., Jensen, N.J., Hawkins, J.A., Mann, E.A., Thompson, M.R., Lentze, M.J., Giannella, R.A. J. Cell. Physiol. (1993) [Pubmed]
  6. Binding of Escherichia coli heat-stable enterotoxin to rat intestinal cells and brush border membranes. Frantz, J.C., Jaso-Friedman, L., Robertson, D.C. Infect. Immun. (1984) [Pubmed]
  7. Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line. Singh, S., Singh, G., Heim, J.M., Gerzer, R. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  8. Structure and function of the heat-stable enterotoxin receptor/guanylyl cyclase C. Vaandrager, A.B. Mol. Cell. Biochem. (2002) [Pubmed]
  9. Phosphorylation and activation of the intestinal guanylyl cyclase receptor for Escherichia coli heat-stable toxin by protein kinase C. Crane, J.K., Shanks, K.L. Mol. Cell. Biochem. (1996) [Pubmed]
  10. An assessment of the Kemble Star 700 sample processor for the automation of complement fixation and ELISA tests in a microbiology laboratory. Amphlett, M., Smith, D.J., Warren, R.E. J. Med. Microbiol. (1991) [Pubmed]
  11. Use of flow cytometry to measure the interaction between Escherichia coli heat-stable enterotoxin and its intestinal receptor in mice. Al-Majali, A.M., Robinson, J.P., Asem, E.K., Lamar, C., Freeman, M.J., Saeed, A.M. J. Immunol. Methods (1999) [Pubmed]
  12. The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine. Swenson, E.S., Mann, E.A., Jump, M.L., Witte, D.P., Giannella, R.A. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  13. Escherichia coli heat-stable enterotoxins, guanylins, and their receptors: what are they and what do they do? Giannella, R.A. J. Lab. Clin. Med. (1995) [Pubmed]
  14. Performance of the automated and rapid STA Liatest D-dimer on the STA-R analyzer. Waser, G., Kathriner, S., Wuillemin, W.A. Thromb. Res. (2005) [Pubmed]
  15. Baseline values of trunk endurance and hip strength in collegiate athletes. Lanning, C.L., Uhl, T.L., Ingram, C.L., Mattacola, C.G., English, T., Newsom, S. Journal of athletic training (2006) [Pubmed]
  16. Reliability and validity of a combat exposure index for Vietnam era veterans. Janes, G.R., Goldberg, J., Eisen, S.A., True, W.R. Journal of clinical psychology. (1991) [Pubmed]
  17. Cl- transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon. Sahi, J., Nataraja, S.G., Layden, T.J., Goldstein, J.L., Moyer, M.P., Rao, M.C. Am. J. Physiol. (1998) [Pubmed]
  18. Effect of dietary insulin on the response of suckling mice enterocytes to Escherichia coli heat-stable enterotoxin. al-Majali, A., Asem, E., Lamar, C., Robinson, J.P., Freeman, M.J., Saeed, M. Vet. Res. (1998) [Pubmed]
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