Gene Review:
Gucy2c - guanylate cyclase 2c
Mus musculus
Synonyms:
AI893437, GC-C, Gcc, Guanylyl cyclase C, Guc2c, ...
- Lack of guanylyl cyclase C, the receptor for Escherichia coli heat-stable enterotoxin, results in reduced polyp formation and increased apoptosis in the multiple intestinal neoplasia (Min) mouse model. Mann, E.A., Steinbrecher, K.A., Stroup, C., Witte, D.P., Cohen, M.B., Giannella, R.A. Int. J. Cancer (2005)
- Renal effects of uroguanylin and guanylin in vivo. Carrithers, S.L., Hill, M.J., Johnson, B.R., O'Hara, S.M., Jackson, B.A., Ott, C.E., Lorenz, J., Mann, E.A., Giannella, R.A., Forte, L.R., Greenberg, R.N. Braz. J. Med. Biol. Res. (1999)
- Guanylin, uroguanylin, and heat-stable euterotoxin activate guanylate cyclase C and/or a pertussis toxin-sensitive G protein in human proximal tubule cells. Sindiće, A., Başoglu, C., Cerçi, A., Hirsch, J.R., Potthast, R., Kuhn, M., Ghanekar, Y., Visweswariah, S.S., Schlatter, E. J. Biol. Chem. (2002)
- Cellular effects of guanylin and uroguanylin. Sindić, A., Schlatter, E. J. Am. Soc. Nephrol. (2006)
- Cloning and mRNA expression of guanylin, uroguanylin, and guanylyl cyclase C in the Spinifex hopping mouse, Notomys alexis. Donald, J.A., Bartolo, R.C. Gen. Comp. Endocrinol. (2003)
- Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. Steinbrecher, K.A., Mann, E.A., Giannella, R.A., Cohen, M.B. Gastroenterology (2001)
- Tyrosine phosphorylation of the human guanylyl cyclase C receptor. Bhandari, R., Mathew, R., Vijayachandra, K., Visweswariah, S. J. Biosci. (2000)
- Guanylin and uroguanylin induce natriuresis in mice lacking guanylyl cyclase-C receptor. Carrithers, S.L., Ott, C.E., Hill, M.J., Johnson, B.R., Cai, W., Chang, J.J., Shah, R.G., Sun, C., Mann, E.A., Fonteles, M.C., Forte, L.R., Jackson, B.A., Giannella, R.A., Greenberg, R.N. Kidney Int. (2004)
- The guanylin/STa receptor is expressed in crypts and apical epithelium throughout the mouse intestine. Swenson, E.S., Mann, E.A., Jump, M.L., Witte, D.P., Giannella, R.A. Biochem. Biophys. Res. Commun. (1996)
- In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers. Giblin, M.F., Sieckman, G.L., Shelton, T.D., Hoffman, T.J., Forte, L.R., Volkert, W.A. Nucl. Med. Biol. (2006)
- Guanylin peptides: cyclic GMP signaling mechanisms. Forte, L.R., Freeman, R.H., Krause, W.J., London, R.M. Braz. J. Med. Biol. Res. (1999)
- In vitro and in vivo Evaluation of (111)In-labeled E. coli Heat-Stable Enterotoxin Analogs for Specific Targeting of Human Breast Cancers. Giblin, M.F., Gali, H., Sieckman, G.L., Owen, N.K., Hoffman, T.J., Volkert, W.A., Forte, L.R. Breast Cancer Res. Treat. (2006)
- Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin/receptor gene. Mann, E.A., Jump, M.L., Glenella, R.A. Biochim. Biophys. Acta (1996)
- High salt intake increases uroguanylin expression in mouse kidney. Potthast, R., Ehler, E., Scheving, L.A., Sindic, A., Schlatter, E., Kuhn, M. Endocrinology (2001)
- A role for guanylate cyclase C in acid-stimulated duodenal mucosal bicarbonate secretion. Rao, S.P., Sellers, Z., Crombie, D.L., Hogan, D.L., Mann, E.A., Childs, D., Keely, S., Sheil-Puopolo, M., Giannella, R.A., Barrett, K.E., Isenberg, J.I., Pratha, V.S. Am. J. Physiol. Gastrointest. Liver Physiol. (2004)
- In vivo imaging of human colon cancer xenografts in immunodeficient mice using a guanylyl cyclase C--specific ligand. Wolfe, H.R., Mendizabal, M., Lleong, E., Cuthbertson, A., Desai, V., Pullan, S., Fujii, D.K., Morrison, M., Pither, R., Waldman, S.A. J. Nucl. Med. (2002)
- Guanylyl cyclase C as a reliable immunohistochemical marker and its ligand Escherichia coli heat-stable enterotoxin as a potential protein-delivering vehicle for colorectal cancer cells. Buc, E., Vartanian, M.D., Darcha, C., Déchelotte, P., Pezet, D. Eur. J. Cancer (2005)