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Gene Review

Cyp27a1  -  cytochrome P450, family 27, subfamily a,...

Rattus norvegicus

Synonyms: 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase, Cyp27, Cytochrome P-450C27/25, Cytochrome P450 27, P450C27, ...
 
 
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Disease relevance of Cyp27a1

  • RESULTS: Continuous squalestatin infusion (15 micrograms/h) decreased C7 alpha H specific activities to 4% and 12% of paired biliary fistula controls at 24 and 48 hours, respectively (P < 0.05) without any changes in S27H specific activities (82% and 95% of controls) [1].
 

High impact information on Cyp27a1

 

Biological context of Cyp27a1

 

Anatomical context of Cyp27a1

 

Associations of Cyp27a1 with chemical compounds

 

Other interactions of Cyp27a1

References

  1. Quantitative estimations of the contribution of different bile acid pathways to total bile acid synthesis in the rat. Vlahcevic, Z.R., Stravitz, R.T., Heuman, D.M., Hylemon, P.B., Pandak, W.M. Gastroenterology (1997) [Pubmed]
  2. Heterogeneous expression of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase genes in the rat liver lobulus. Twisk, J., Hoekman, M.F., Mager, W.H., Moorman, A.F., de Boer, P.A., Scheja, L., Princen, H.M., Gebhardt, R. J. Clin. Invest. (1995) [Pubmed]
  3. Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes. Pandak, W.M., Hylemon, P.B., Ren, S., Marques, D., Gil, G., Redford, K., Mallonee, D., Vlahcevic, Z.R. Hepatology (2002) [Pubmed]
  4. Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7alpha-hydroxylase in cultured rat hepatocytes and in vivo in the rat. Post, S.M., Zoeteweij, J.P., Bos, M.H., de Wit, E.C., Havinga, R., Kuipers, F., Princen, H.M. Hepatology (1999) [Pubmed]
  5. Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes. Pandak, W.M., Ren, S., Marques, D., Hall, E., Redford, K., Mallonee, D., Bohdan, P., Heuman, D., Gil, G., Hylemon, P. J. Biol. Chem. (2002) [Pubmed]
  6. Cafestol, the cholesterol-raising factor in boiled coffee, suppresses bile acid synthesis by downregulation of cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase in rat hepatocytes. Post, S.M., de Wit, E.C., Princen, H.M. Arterioscler. Thromb. Vasc. Biol. (1997) [Pubmed]
  7. Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7alpha-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes. Post, S.M., Twisk, J., van der Fits, L., de Wit, E.C., Hoekman, M.F., Mager, W.H., Princen, H.M. Biochem. J. (1999) [Pubmed]
  8. Bile acid synthesis in the Smith-Lemli-Opitz syndrome: effects of dehydrocholesterols on cholesterol 7alpha-hydroxylase and 27-hydroxylase activities in rat liver. Honda, A., Salen, G., Shefer, S., Batta, A.K., Honda, M., Xu, G., Tint, G.S., Matsuzaki, Y., Shoda, J., Tanaka, N. J. Lipid Res. (1999) [Pubmed]
  9. Assay method for mitochondrial sterol 27-hydroxylase with 7alpha-hydroxy-4-cholesten-3-one as a substrate in the rat liver. Ota, Y., Eto, T.A., Tanaka, S., Sueta, H., Shiotsuki, H., Maeda, Y., Une, M., Chijiiwa, K. J. Lipid Res. (2003) [Pubmed]
  10. Purification and characterization of 5 beta-cholestane-3 alpha,7 alpha,12 alpha-triol 27-hydroxylase from female rat liver mitochondria. Okuda, K., Masumoto, O., Ohyama, Y. J. Biol. Chem. (1988) [Pubmed]
  11. Regulation of sterol 27-hydroxylase and an alternative pathway of bile acid biosynthesis in primary cultures of rat hepatocytes. Stravitz, R.T., Vlahcevic, Z.R., Russell, T.L., Heizer, M.L., Avadhani, N.G., Hylemon, P.B. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  12. Regulation of bile acid synthesis by deoxycholic acid in the rat: different effects on cholesterol 7 alpha-hydroxylase and sterol 27-hydroxylase. Shefer, S., Kren, B.T., Salen, G., Steer, C.J., Nguyen, L.B., Chen, T., Tint, G.S., Batta, A.K. Hepatology (1995) [Pubmed]
  13. Synthesis of 27-hydroxycholesterol in rat liver mitochondria: HPLC assay and marked activation by exogenous cholesterol. Petrack, B., Latario, B.J. J. Lipid Res. (1993) [Pubmed]
  14. Effect of maternal cholestasis and treatment with ursodeoxycholic acid on the expression of genes involved in the secretion of biliary lipids by the neonatal rat liver. Macias, R.I., Jimenez, S., Serrano, M.A., Monte, M.J., Marin, J.J. Life Sci. (2006) [Pubmed]
  15. Transient changes in the expression pattern of key enzymes for bile acid synthesis during rat liver regeneration. Monte, M.J., Fernandez-Tagarro, M., Marin, J.J. Biochim. Biophys. Acta (2005) [Pubmed]
 
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