Chemical Compound Review:
SureCN178019 (7R,8S,9S,10R,13R,14S,17R)-7- hydroxy-10,13...
Synonyms:
CPD-1087, AG-F-36198, CHEBI:17899, HMDB01993, CTK1C2654, ...
Boekschoten,
Hofman,
Buytenhek,
Schouten,
Princen,
Katan,
Honda,
Salen,
Matsuzaki,
Batta,
Xu,
Hirayama,
Tint,
Doy,
Shefer,
Leonsson,
Oscarsson,
Bosaeus,
Lundgren,
Johannsson,
Wiklund,
Bengtsson,
Maeda,
Nagatomo,
Uchiyama,
Nagatomo,
Yamada,
Shiotsuki,
Ohta,
Sato,
Kai,
Kondo,
Higashi,
Setoguchi,
Naoumova,
O'Neill,
Dunn,
Neuwirth,
Taylor,
Axelson,
Thompson,
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- Accumulation of 7 alpha-hydroxy-4-cholesten-3-one and cholesta-4,6-dien-3-one in patients with cerebrotendinous xanthomatosis: effect of treatment with chenodeoxycholic acid. Björkhem, I., Skrede, S., Buchmann, M.S., East, C., Grundy, S. Hepatology (1987)
- Bile acid biosynthesis: the metabolism of 7 alpha-hydroxy-4-cholesten-3-one in the bile fistula rat. Sherman, C.A., Hanson, R.F. Steroids (1976)
- Plasma levels of mevalonate and 7alpha-hydroxy-4-cholesten-3-one in chronic liver disease. Yoshida, T., Honda, A., Matsuzaki, Y., Shoda, J., Abei, M., Tanaka, N., Osuga, T. J. Gastroenterol. Hepatol. (1999)
- Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits. Honda, A., Yoshida, T., Xu, G., Matsuzaki, Y., Fukushima, S., Tanaka, N., Doy, M., Shefer, S., Salen, G. Metab. Clin. Exp. (2004)
- Lack of 3 beta-hydroxy-delta 5-C27-steroid dehydrogenase/isomerase in fibroblasts from a child with urinary excretion of 3 beta-hydroxy-delta 5-bile acids. A new inborn error of metabolism. Buchmann, M.S., Kvittingen, E.A., Nazer, H., Gunasekaran, T., Clayton, P.T., Sjövall, J., Björkhem, I. J. Clin. Invest. (1990)
- Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor. Goodwin, B., Gauthier, K.C., Umetani, M., Watson, M.A., Lochansky, M.I., Collins, J.L., Leitersdorf, E., Mangelsdorf, D.J., Kliewer, S.A., Repa, J.J. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Serum concentrations of 7alpha-hydroxy-4-cholesten-3-one reflect bile acid synthesis in humans. Sauter, G., Berr, F., Beuers, U., Fischer, S., Paumgartner, G. Hepatology (1996)
- Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase. Okuda, A., Okuda, K. J. Biol. Chem. (1984)
- Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme. Kondo, K.H., Kai, M.H., Setoguchi, Y., Eggertsen, G., Sjöblom, P., Setoguchi, T., Okuda, K.I., Björkhem, I. Eur. J. Biochem. (1994)
- Effect of inhibiting HMG-CoA reductase on 7 alpha-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up-regulation of the latter pathway. Naoumova, R.P., O'Neill, F.H., Dunn, S., Neuwirth, C.K., Taylor, G.W., Axelson, M., Thompson, G.R. Eur. J. Clin. Invest. (1999)
- Determination of 7 alpha-hydroxy-4-cholesten-3-one level in plasma using isotope-dilution mass spectrometry and monitoring its circadian rhythm in human as an index of bile acid biosynthesis. Yoshida, T., Honda, A., Tanaka, N., Matsuzaki, Y., Shoda, J., He, B., Osuga, T., Miyazaki, H. J. Chromatogr. B, Biomed. Appl. (1994)
- Formation of bile acids in man. Metabolism of 7alpha-hydroxy-4-cholesten-3-one in normal subjects with an intact enterohepatic circulation. Hanson, R.F., Szczepanik, P.A., Klein, P.D., Johnson, E.A., Williams, G.C. Biochim. Biophys. Acta (1976)
- Rabbit liver contains one major sterol 12alpha-hydroxylase with broad substrate specificity. Andersson, U., Eggertsen, G., Björkhem, I. Biochim. Biophys. Acta (1998)
- Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids. Wikvall, K. J. Biol. Chem. (1984)
- The role of sterol carrier protein2 and other hepatic lipid-binding proteins in bile-acid biosynthesis. Lidström-Olsson, B., Wikvall, K. Biochem. J. (1986)
- Cerebrotendinous xanthomatosis: defective liver mitochondrial hydroxylation of chenodeoxycholic acid precursors. Oftebro, H., Björkhem, I., Størmer, F.C., Pedersen, J.I. J. Lipid Res. (1981)
- Monitoring hepatic cholesterol 7alpha-hydroxylase activity by assay of the stable bile acid intermediate 7alpha-hydroxy-4-cholesten-3-one in peripheral blood. Gälman, C., Arvidsson, I., Angelin, B., Rudling, M. J. Lipid Res. (2003)
- Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis. Honda, A., Salen, G., Matsuzaki, Y., Batta, A.K., Xu, G., Hirayama, T., Tint, G.S., Doy, M., Shefer, S. J. Lipid Res. (2005)
- Hepatic 7 alpha-dehydroxylation of bile acid intermediates, and its significance for the pathogenesis of cerebrotendinous xanthomatosis. Skrede, S., Buchmann, M.S., Björkhem, I. J. Lipid Res. (1988)
- Coffee oil consumption increases plasma levels of 7alpha-hydroxy-4-cholesten-3-one in humans. Boekschoten, M.V., Hofman, M.K., Buytenhek, R., Schouten, E.G., Princen, H.M., Katan, M.B. J. Nutr. (2005)
- A comparative study of the conversion of 7-hydroxycholesterol in rabbit, guinea pig, rat, hamster, and chicken. Maeda, Y., Nagatomo, H., Uchiyama, F., Nagatomo, J., Yamada, M., Shiotsuki, H., Ohta, Y., Sato, S., Kai, M.H., Kondo, K.H., Higashi, S., Setoguchi, T. Steroids (2002)
- Effect of streptozotocin-induced diabetes on the activity of 7 alpha-hydroxy-4-cholesten-3-one-specific 12 alpha-hydroxylase in rats. Kimura, K., Ogura, M. Biol. Chem. Hoppe-Seyler (1988)
- Growth hormone (GH) therapy in GH-deficient adults influences the response to a dietary load of cholesterol and saturated fat in terms of cholesterol synthesis, but not serum low density lipoprotein cholesterol levels. Leonsson, M., Oscarsson, J., Bosaeus, I., Lundgren, B.K., Johannsson, G., Wiklund, O., Bengtsson, B.A. J. Clin. Endocrinol. Metab. (1999)
- Assay method for mitochondrial sterol 27-hydroxylase with 7alpha-hydroxy-4-cholesten-3-one as a substrate in the rat liver. Ota, Y., Eto, T.A., Tanaka, S., Sueta, H., Shiotsuki, H., Maeda, Y., Une, M., Chijiiwa, K. J. Lipid Res. (2003)
- Effect of cholestyramine on bile acid pattern and synthesis during administration of ursodeoxycholic acid in man. Rust, C., Sauter, G.H., Oswald, M., Büttner, J., Kullak-Ublick, G.A., Paumgartner, G., Beuers, U. Eur. J. Clin. Invest. (2000)
- Serum 7 alpha-hydroxy-4-cholesten-3-one and selenohomocholyltaurine (SeHCAT) whole body retention in the assessment of bile acid induced diarrhoea. Brydon, W.G., Nyhlin, H., Eastwood, M.A., Merrick, M.V. European journal of gastroenterology & hepatology. (1996)
- Cholesterol 7 alpha-hydroxylase activity in hypothyroidism and hyperthyroidism in humans. Sauter, G., Weiss, M., Hoermann, R. Horm. Metab. Res. (1997)